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Entry version 67 (07 Oct 2020)
Sequence version 1 (12 Jun 2007)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Bunyavirus La Crosse
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate. During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism. It consists in the hijacking and cleavage via N-terminal endonuclease activity of host capped pre-mRNAs (PubMed:20862319). These short capped RNAs are then used as primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are not polyadenylated. During replication, the polymerase binds the 5' and 3' vRNA extremities at distinct sites. In turn, significant conformational changes occur in the polymerase and in vRNA to initiate active RNA synthesis (PubMed:26004069). As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated (PubMed:20862319).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi34Manganese; via tele nitrogen 11 Publication1
Metal bindingi52Manganese 21 Publication1
Metal bindingi79Manganese 11 Publication1
Metal bindingi79Manganese 21 Publication1
Metal bindingi92Manganese 11 Publication1
Metal bindingi93Manganese 1; via carbonyl oxygen1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandManganese, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48, EC:3.1.-.-)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBunyavirus La Crosse
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11577 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesPeribunyaviridaeOrthobunyavirusLa Crosse orthobunyavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000126351 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi34H → A: Complete loss of nuclease activity. 1 Publication1
Mutagenesisi52D → A: Complete loss of nuclease activity. 1 Publication1
Mutagenesisi79D → A: Complete loss of nuclease activity. 1 Publication1
Mutagenesisi92D → A: Complete loss of nuclease activity. 1 Publication1
Mutagenesisi94K → A: Complete loss of nuclease activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004457391 – 2263RNA-directed RNA polymerase LAdd BLAST2263

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimerizes; the oligomeric structure is essential for the polymerase activity.

Interacts with the nucleocapsid protein N.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A5HC98

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A5HC98

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1042 – 1230RdRp catalyticPROSITE-ProRule annotationAdd BLAST189

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1186 – 1188Catalytic motif1 Publication3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal possesses an endonuclease domain that is essential for viral cap-dependent transcription.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Database of protein disorder

More...
DisProti
DP02521

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029124, L_protein_N
IPR007099, RNA-dir_pol_NSvirus
IPR014384, RNA-dir_pol_orthobunyavirus
IPR007322, RNA_pol_bunyavir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04196, Bunya_RdRp, 1 hit
PF15518, L_protein_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000824, L_OrthobunV, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50525, RDRP_SSRNA_NEG_SEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5HC98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYQEYQQFL ARINTARDAC VAKDIDVDLL MARHDYFGRE LCKSLNIEYR
60 70 80 90 100
NDVPFIDIIL DIRPEVDPLT IDAPHITPDN YLYINNVLYI IDYKVSVSNE
110 120 130 140 150
SSVITYDKYY ELTRDISDRL SIPIEIVIIR IDPVSRDLHI NSDRFKELYP
160 170 180 190 200
TIVVDINFNQ FFDLKQLLYE KFGDDEEFLL KVAHGDFTLT APWCKTGCPE
210 220 230 240 250
FWKHPIYKEF KMSMPVPERR LFEESVKFNA YESERWNTNL VKIREYTKKD
260 270 280 290 300
YSEHISKSAK NIFLASGFYK QPNKNEISEG WTLMVERVQD QREISKSLHD
310 320 330 340 350
QKPSIHFIWG AHNPGNSNNA TFKLILLSKS LQSIKGISTY TEAFKSLGKM
360 370 380 390 400
MDIGDKAIEY EEFCMSLKSK ARSSWKQIMN KKLEPKQINN ALVLWEQQFM
410 420 430 440 450
INNDLIDKSE KLKLFKNFCG IGKHKQFKNK MLEDLEVSKP KILDFDDANM
460 470 480 490 500
YLASLTMMEQ SKKILSKSNG LKPDNFILNE FGSRIKDANK ETYDNMHKIF
510 520 530 540 550
ETGYWQCISD FSTLMKNILS VSQYNRHNTF RIAMCANNNV FAIVFPSADI
560 570 580 590 600
KTKKATVVYS IIVLHKEEEN IFNPGCLHGT FKCMNGYISI SRAIRLDKER
610 620 630 640 650
CQRIVSSPGL FLTTCLLFKH DNPTLVMSDI MNFSIYTSLS ITKSVLSLTE
660 670 680 690 700
PARYMIMNSL AISSNVKDYI AEKFSPYTKT LFSVYMTRLI KNACFDAYDQ
710 720 730 740 750
RQRVQLRDIY LSDYDITQKG IKDNRELTSI WFPGSVTLKE YLTQIYLPFY
760 770 780 790 800
FNAKGLHEKH HVMVDLAKTI LEIECEQREN IKEIWSTNCT KQTVNLKILI
810 820 830 840 850
HSLCKNLLAD TSRHNHLRNR IENRNNFRRS ITTISTFTSS KSCLKIGDFR
860 870 880 890 900
KEKELQSVKQ KKILEVQSRK MRLANPMFVT DEQVCLEVGH CNYEMLRNAM
910 920 930 940 950
PNYTDYISTK VFDRLYELLD KKVLTDKPVI EQIMDMMIDH KKFYFTFFNK
960 970 980 990 1000
GQKTSKDREI FVGEYEAKMC MYAVERIAKE RCKLNPDEMI SEPGDGKLKV
1010 1020 1030 1040 1050
LEQKSEQEIR FLVETTRQKN REIDEAIEAL ATEGYESNLG KIEKLSLGKA
1060 1070 1080 1090 1100
KGLKMEINAD MSKWSAQDVF YKYFWLIALD PILYPQEKER ILYFMCNYMD
1110 1120 1130 1140 1150
KELILPDELL FNLLDQKVAY QNDIIATMTN QLNSNTVLIK RNWLQGNFNY
1160 1170 1180 1190 1200
TSSYVHSCAM SVYKEILKEA ITLLDGSILV NSLVHSDDNQ TSITIVQDKM
1210 1220 1230 1240 1250
ENDKIIDFAM KEFERACLTF GCQANMKKTY VTNCIKEFVS LFNLYGEPFS
1260 1270 1280 1290 1300
IYGRFLLTSV GDCAYIGPYE DLASRISSAQ TAIKHGCPPS LAWVSIAISH
1310 1320 1330 1340 1350
WMTSLTYNML PGQSNDPIDY FPAENRKDIP IELNGVLDAP LSMISTVGLE
1360 1370 1380 1390 1400
SGNLYFLIKL LSKYTPVMQK RESVVNQIAE VKNWKVEDLT DNEIFRLKIL
1410 1420 1430 1440 1450
RYLVLDAEMD PSDIMGETSD MRGRSILTPR KFTTAGSLRK LYSFSKYQDR
1460 1470 1480 1490 1500
LSSPGGMVEL FTYLLEKPEL LVTKGEDMKD YMESVIFRYN SKRFKESLSI
1510 1520 1530 1540 1550
QNPAQLFIEQ ILFSHKPVID FSGIRDKYIN LHDSRALEKE PDILGKVTFT
1560 1570 1580 1590 1600
EAYRLLMRDL SSLELTNDDI QVIYSYIILN DPMMITIANT HILSIYGSPQ
1610 1620 1630 1640 1650
RRMGMSCSTM PEFRNLKLIH HSPALVLRAY SKNNPDIQGA DPTEMARDLV
1660 1670 1680 1690 1700
HLKEFVENTN LEEKMKVRIA MNEAEKGQRD IVFELKEMTR FYQVCYEYVK
1710 1720 1730 1740 1750
STEHKIKVFI LPAKSYTTTD FCSLMQGNLI KDKEWYTVHY LKQILSGGHK
1760 1770 1780 1790 1800
AIMQHNATSE QNIAFECFKL ITHFADSFID SLSRSAFLQL IIDEFSYKDV
1810 1820 1830 1840 1850
KVSKLYDIIK NGYNRTDFIP LLFRTGDLRQ ADLDKYDAMK SHERVTWNDW
1860 1870 1880 1890 1900
QTSRHLDMGS INLTITGYNR SITIIGEDNK LTYAELCLTR KTPENITISG
1910 1920 1930 1940 1950
RKLLGSRHGL KFENMSKIQT YPGNYYITYR KKDRHQFVYQ IHSHESITRR
1960 1970 1980 1990 2000
NEEHMAIRTR IYNEITPVCV VNVAEVDGDQ RILIRSLDYL NNDIFSLSRI
2010 2020 2030 2040 2050
KVGLDEFATI KKAHFSKMVS FEGPPIKTGL LDLTELMKSQ DLLNLNYDNI
2060 2070 2080 2090 2100
RNSNLISFSK LICCEGSDNI NDGLEFLSDD PMNFTEGEAI HSTPIFNIYY
2110 2120 2130 2140 2150
SKRGERHMTY RNAIKLLIER ETKIFEEAFT FSENGFISPE NLGCLEAVVS
2160 2170 2180 2190 2200
LIKLLKTNEW STVIDKCIHI CLIKNGMDHM YHSFDVPKCF MGNPITRDIN
2210 2220 2230 2240 2250
WVMFREFINS LPGTDIPPWN VMTENFKKKC IALINSKFET QRDFSEFTKL
2260
MKKEGGRSNI EFD
Length:2,263
Mass (Da):263,029
Last modified:June 12, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1EBA368F8D20FDD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF485038 Viral cRNA Translation: ABQ12639.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF485038 Viral cRNA Translation: ABQ12639.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XI5X-ray2.20A/B/C/D1-183[»]
2XI7X-ray2.20A/B/C/D1-183[»]
5AMQX-ray3.00A1-2263[»]
5AMRX-ray2.57A1-2263[»]
SMRiA5HC98
ModBaseiSearch...
PDBe-KBiSearch...

Miscellaneous databases

EvolutionaryTraceiA5HC98

Family and domain databases

DisProtiDP02521
InterProiView protein in InterPro
IPR029124, L_protein_N
IPR007099, RNA-dir_pol_NSvirus
IPR014384, RNA-dir_pol_orthobunyavirus
IPR007322, RNA_pol_bunyavir
PfamiView protein in Pfam
PF04196, Bunya_RdRp, 1 hit
PF15518, L_protein_N, 1 hit
PIRSFiPIRSF000824, L_OrthobunV, 1 hit
PROSITEiView protein in PROSITE
PS50525, RDRP_SSRNA_NEG_SEG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_BUNLC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5HC98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2018
Last sequence update: June 12, 2007
Last modified: October 7, 2020
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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