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Entry version 119 (02 Jun 2021)
Sequence version 1 (12 Jun 2007)
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Protein
Submitted name:

Ribonuclease L

Gene

RNASEL

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-8983711, OAS antiviral response
R-BTA-909733, Interferon alpha/beta signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ribonuclease LImported
Submitted name:
Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNASELImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:34003, RNASEL

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000009091, Expressed in testis and 92 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000041757

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 303ANK_REP_REGIONInterPro annotationAdd BLAST280
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati24 – 56ANKPROSITE-ProRule annotationAdd BLAST33
Repeati57 – 89ANKPROSITE-ProRule annotationAdd BLAST33
Repeati90 – 122ANKPROSITE-ProRule annotationAdd BLAST33
Repeati123 – 155ANKPROSITE-ProRule annotationAdd BLAST33
Repeati166 – 199ANKPROSITE-ProRule annotationAdd BLAST34
Domaini364 – 584Protein kinaseInterPro annotationAdd BLAST221
Domaini587 – 719KENInterPro annotationAdd BLAST133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 24Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1027, Eukaryota
KOG4177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161114

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022542_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VLYVVRK

Database of Orthologous Groups

More...
OrthoDBi
222916at2759

TreeFam database of animal gene trees

More...
TreeFami
TF344032

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10423, RNase_RNase-L, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1440.180, 1 hit
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR010513, KEN_dom
IPR038357, KEN_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR042745, RNase-L_RNase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 3 hits
PF00069, Pkinase, 1 hit
PF06479, Ribonuc_2-5A, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 8 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS51392, KEN, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5H027-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METESHNNPQ ERPTPSSNGK ASMGDNHSLI KAVRDEDIES VQQLLERGAD
60 70 80 90 100
VNFQEEWGWS PLHNAVQVDR EDIVELLLSH GAEPCLRKKN GATPFIIAGI
110 120 130 140 150
VGNVKLLKLL LPKVTDVNEC DVNGFTAFME AAVYGKVEAL RFLYNNGAEV
160 170 180 190 200
NLHRKTIEDQ ERVKKGGATA LMDAARRGHV DVVEILLHEM GADVNARDNR
210 220 230 240 250
GRNALIYALL NSDDEKVKAI TRLLLDYKVD VNVRGEGRKT PLILAVEKKN
260 270 280 290 300
LDLVQMLLEQ TAIEINDTDS EGKTALLLAV ELKLKEIAQL LCRKGASTKC
310 320 330 340 350
GDLVAIAKRN YDSDLAKFLR QHGAVEDVCP PAKAWKPQSS RWGEALKHLH
360 370 380 390 400
RIYRPMIGKL KIFIDEEYKI ADTSQGGIYL GLYEEQEVAV KRFPKGSTRG
410 420 430 440 450
QNEVSCLQSN RANGHVVTFY GSESDRTCLY VCLALCEHTL EKHLDDRKGE
460 470 480 490 500
AVQNKEDEFA RNILSSLFKA VEELHRSGYT HQDLQPQNIL IDSKNGACLA
510 520 530 540 550
DFDKSVKGTG DPQEIKRDLE ALGLLVLYVV KKGNDSFEML KNLRTEELIE
560 570 580 590 600
RSPDKETRDL IQHLLVPGDN VKGHLSGLLA HPFFWSWESR YRTLRDVGNE
610 620 630 640 650
SDIKTRNTNG KILQLLQPET SELPSFAQWT IEVDKSVMKK MNAFYKKGNT
660 670 680 690 700
YQNTVGDLLK FIRNVGEHIN EQKNIEMKSK IGEPSQYFQE KFPDLVMYVY
710 720
KRLQNTEYAK HFPKNLNLNK ADV
Length:723
Mass (Da):81,702
Last modified:June 12, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0533B0CEAFB01E1D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC142502 mRNA Translation: AAI42503.1
DQ497162 mRNA Translation: ABF55364.1

NCBI Reference Sequences

More...
RefSeqi
NP_001091634.1, NM_001098165.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000044248; ENSBTAP00000041757; ENSBTAG00000009091

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100048947

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:100048947

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142502 mRNA Translation: AAI42503.1
DQ497162 mRNA Translation: ABF55364.1
RefSeqiNP_001091634.1, NM_001098165.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041757

Genome annotation databases

EnsembliENSBTAT00000044248; ENSBTAP00000041757; ENSBTAG00000009091
GeneIDi100048947
KEGGibta:100048947

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6041
VGNCiVGNC:34003, RNASEL

Phylogenomic databases

eggNOGiKOG1027, Eukaryota
KOG4177, Eukaryota
GeneTreeiENSGT00940000161114
HOGENOMiCLU_022542_0_0_1
OMAiVLYVVRK
OrthoDBi222916at2759
TreeFamiTF344032

Enzyme and pathway databases

ReactomeiR-BTA-8983711, OAS antiviral response
R-BTA-909733, Interferon alpha/beta signaling

Gene expression databases

BgeeiENSBTAG00000009091, Expressed in testis and 92 other tissues

Family and domain databases

CDDicd10423, RNase_RNase-L, 1 hit
Gene3Di1.20.1440.180, 1 hit
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR010513, KEN_dom
IPR038357, KEN_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR042745, RNase-L_RNase
PfamiView protein in Pfam
PF12796, Ank_2, 3 hits
PF00069, Pkinase, 1 hit
PF06479, Ribonuc_2-5A, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 8 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS51392, KEN, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5H027_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5H027
Secondary accession number(s): E1BC88
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: June 2, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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