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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Synechococcus sp. (strain RCC307)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei623For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciSSP316278:G1GJL-134-MONOMER

Protein family/group databases

MEROPSiC44.A08

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotationImported
Ordered Locus Names:SynRCC307_0134Imported
OrganismiSynechococcus sp. (strain RCC307)Imported
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001115 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316278.SynRCC307_0134

Structurei

3D structure databases

ProteinModelPortaliA5GQ78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 228Glutamine amidotransferase type-2InterPro annotationAdd BLAST227
Domaini296 – 445SISInterPro annotationAdd BLAST150
Domaini479 – 618SISInterPro annotationAdd BLAST140

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5GQ78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIVAVIGT RDAAPLLLDG LRQLEYRGYD SAGIATVHGG HLSHLRAEGK
60 70 80 90 100
LINLTQRFEA SGAAGSCGIG HTRWATHGKP EERNAHPHLD GSGELAVVQN
110 120 130 140 150
GIIENHRSLR ERLAAGGAAF QSDTDTEVIP HLVSQELKGL LAAGSPADGA
160 170 180 190 200
TLLKAVQQAL PQLDGAYALA VVWAQCPDAL VVARRQAPLL IGFGEGEFLC
210 220 230 240 250
ASDTPALAGV TRTILPLEDG EVALLGPLGI ELYNEAGERQ QRPPTQLQGT
260 270 280 290 300
DHVADKRSFR HFMLKEIHEQ PETAARWLLR HLPEGGPNDP LVALPLERSL
310 320 330 340 350
LEGVQRIQIL ACGTSRHAAL VGAHLLEQLA GIPTSVHYAS EFRYSPPPLA
360 370 380 390 400
PHTLTIGVTQ SGETADTLAA LAMEQQRCAD HGDPAYAARL LGITNRTESS
410 420 430 440 450
LGRLVPQLID IAAGVEVGVA ATKTFLGQLL AFYGLAIQLT DLRGARSREQ
460 470 480 490 500
LHPLLAELRA LPAQLQTLID RLDLRCAELA HAFADTRTVI YLGRGINYPI
510 520 530 540 550
ALEGALKLKE ISYIHAEGYP AGEMKHGPIA LLDADVPVVS VAMPGPVFDK
560 570 580 590 600
VLSNAQEAKA RDARLIGVAP ECPDTEIFDE LLPVPAVDEL LSPLLTLIPM
610 620
QLLSYHIAAR RGLDVDQPRN LAKSVTVE
Length:628
Mass (Da):67,185
Last modified:June 12, 2007 - v1
Checksum:i2F6B182E0107A5EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT978603 Genomic DNA Translation: CAK27037.1
RefSeqiWP_011934552.1, NC_009482.1

Genome annotation databases

EnsemblBacteriaiCAK27037; CAK27037; SynRCC307_0134
KEGGisyr:SynRCC307_0134

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT978603 Genomic DNA Translation: CAK27037.1
RefSeqiWP_011934552.1, NC_009482.1

3D structure databases

ProteinModelPortaliA5GQ78
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316278.SynRCC307_0134

Protein family/group databases

MEROPSiC44.A08

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK27037; CAK27037; SynRCC307_0134
KEGGisyr:SynRCC307_0134

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Enzyme and pathway databases

BioCyciSSP316278:G1GJL-134-MONOMER

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA5GQ78_SYNR3
AccessioniPrimary (citable) accession number: A5GQ78
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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