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Protein

tRNA dimethylallyltransferase

Gene

miaA

Organism
Synechococcus sp. (strain RCC307)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i6A).UniRule annotation

Catalytic activityi

Dimethylallyl diphosphate + adenine(37) in tRNA = diphosphate + N6-dimethylallyladenine(37) in tRNA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processtRNA processing
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP316278:G1GJL-92-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA dimethylallyltransferaseUniRule annotation (EC:2.5.1.75UniRule annotation)
Alternative name(s):
Dimethylallyl diphosphate:tRNA dimethylallyltransferaseUniRule annotation
Short name:
DMAPP:tRNA dimethylallyltransferaseUniRule annotation
Short name:
DMATaseUniRule annotation
Isopentenyl-diphosphate:tRNA isopentenyltransferaseUniRule annotation
Short name:
IPP transferaseUniRule annotation
Short name:
IPPTUniRule annotation
Short name:
IPTaseUniRule annotation
Gene namesi
Name:miaAUniRule annotation
Ordered Locus Names:SynRCC307_0091
OrganismiSynechococcus sp. (strain RCC307)
Taxonomic identifieri316278 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001115 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003773481 – 296tRNA dimethylallyltransferaseAdd BLAST296

Interactioni

Subunit structurei

Monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei101Interaction with substrate tRNAUniRule annotation1

Protein-protein interaction databases

STRINGi316278.SynRCC307_0091

Structurei

3D structure databases

ProteinModelPortaliA5GQ35
SMRiA5GQ35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 17Substrate bindingUniRule annotation6
Regioni35 – 38Interaction with substrate tRNAUniRule annotation4

Sequence similaritiesi

Belongs to the IPP transferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DKX Bacteria
COG0324 LUCA
HOGENOMiHOG000039996
KOiK00791
OMAiGTGLYIR
OrthoDBiPOG091H00NK

Family and domain databases

HAMAPiMF_00185 IPP_trans, 1 hit
InterProiView protein in InterPro
IPR018022 IPT
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01715 IPPT, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00174 miaA, 1 hit

Sequencei

Sequence statusi: Complete.

A5GQ35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPLMVLVLG PTASGKTSLG IALAQQLDCR VLSIDSRQLY AGMDIGTAKP
60 70 80 90 100
TRDEQQQARH ELLNLSTPDQ PINLQQFCSH AQTLIEQEQQ RGRPALLVGG
110 120 130 140 150
SGLYLQALSQ GLQPPALPPQ TGLRQQLQQL GQSCCHQLLS QADPQAAAKI
160 170 180 190 200
EPNDPVRTQR ALEVLYGTGQ TISSQQGRCP PACRVLELGL NPSDLKERIE
210 220 230 240 250
QRTASLYARG LVAETETLSR RYGADLPLLQ TIGYGEALAV LAGRLSESEA
260 270 280 290
QALTSRRTWL FAKRQRTWFR NRHQPLWLNT ESALEEALEA IAAARS
Length:296
Mass (Da):32,461
Last modified:June 12, 2007 - v1
Checksum:i46B020817AD9334D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT978603 Genomic DNA Translation: CAK26994.1
RefSeqiWP_011934509.1, NC_009482.1

Genome annotation databases

EnsemblBacteriaiCAK26994; CAK26994; SynRCC307_0091
KEGGisyr:SynRCC307_0091

Similar proteinsi

Entry informationi

Entry nameiMIAA_SYNR3
AccessioniPrimary (citable) accession number: A5GQ35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 12, 2007
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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