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Protein

Argininosuccinate lyase

Gene

argH

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciGURA351605:G1G8X-232-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Gura_0231
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000006695 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000738471 – 458Argininosuccinate lyaseAdd BLAST458

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_0231

Structurei

3D structure databases

ProteinModelPortaliA5GDA7
SMRiA5GDA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A5GDA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDKLWGGR FTQPTDKFVE EFTASIDFDK RLYHQDIRGS IAHARMLGKQ
60 70 80 90 100
KIIPMADVEK IVQGLQEILA QIEAGTFDFS ISLEDIHMNI ESRLSAKIGE
110 120 130 140 150
AGKRLHTGRS RNDQVALDIR LYLRDELVEI SAYLELLIDS LIFQAEKNID
160 170 180 190 200
VIMPGYTHLQ TAQPILFAHH MLAYVEMFKR DIGRIEDCLK RANVLPLGAG
210 220 230 240 250
ALAGTTFPID REHVAELLDF PAVTRNSLDS VSDRDFALEF LADASILMMH
260 270 280 290 300
LSRFSEELIL WSTSEFKFIE LSDGFCTGSS IMPQKKNPDV PELVRGKTGR
310 320 330 340 350
VYGNLMALLT VMKSLPLAYN KDMQEDKEPL FDTIDTVKGS LKIFADMIRE
360 370 380 390 400
MRVNVATMRQ AAAKGFSTAT DVADYLVRKG MPFRDAHEVV GKSVAYCIAE
410 420 430 440 450
KKDLPELSIE EWRSFSDKID EDIYDAITLE ASVNARRATG GTALERVKAE

IERAKVGR
Length:458
Mass (Da):51,550
Last modified:June 12, 2007 - v1
Checksum:i3D8B72CB9E52AE2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA Translation: ABQ24447.1
RefSeqiWP_011937176.1, NC_009483.1

Genome annotation databases

EnsemblBacteriaiABQ24447; ABQ24447; Gura_0231
KEGGigur:Gura_0231

Similar proteinsi

Entry informationi

Entry nameiARLY_GEOUR
AccessioniPrimary (citable) accession number: A5GDA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: February 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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