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Protein

Argininosuccinate synthase

Gene

argG

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei90CitrullineUniRule annotation1
Binding sitei95CitrullineUniRule annotation1
Binding sitei120ATP; via amide nitrogenUniRule annotation1
Binding sitei122AspartateUniRule annotation1
Binding sitei126AspartateUniRule annotation1
Binding sitei126CitrullineUniRule annotation1
Binding sitei127AspartateUniRule annotation1
Binding sitei130CitrullineUniRule annotation1
Binding sitei179CitrullineUniRule annotation1
Binding sitei188CitrullineUniRule annotation1
Binding sitei264CitrullineUniRule annotation1
Binding sitei276CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGURA351605:G1G8X-229-MONOMER
UniPathwayi
UPA00068;UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Gura_0228
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000006695 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294701 – 406Argininosuccinate synthaseAdd BLAST406

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi351605.Gura_0228

Structurei

3D structure databases

ProteinModelPortaliA5GDA4
SMRiA5GDA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5GDA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKKEVKKIV LAYSGGLDTS IILKWLKNEY GCEVITFSAD LGQGDELTPI
60 70 80 90 100
RDKAFATGAD KVYIDDLREE FVRDFVFPMF RANAIYEGHY LLGTSIARPL
110 120 130 140 150
IAKRQMEIAK IEGADAVSHG ATGKGNDQVR FELGYYHFNP AITVIAPWRD
160 170 180 190 200
WKLNSRQALI NYAKKNDIPI PVTKKRPWSS DRNLLHISFE GAILEDTWAE
210 220 230 240 250
APENMYVLTK SPEKAPNKPQ YVEIEFRNGN AVAVDGEAMS PAQLLAHLNF
260 270 280 290 300
IGGEHGIGRV DLLENRSVGM KSRGVYETPG GTILREAHMA VEQITMDREV
310 320 330 340 350
MHLRDSLIPR YAEMVYNGYW FSPEREMLQT MIDESQKTVN GVARVKLYKG
360 370 380 390 400
HCRTVGRKSE TDSLFNLDFA TFEKDQVYNQ KDAEGFIKLN SLRLRIRSLM

QAAKKK
Length:406
Mass (Da):46,034
Last modified:June 12, 2007 - v1
Checksum:i70CFBA76F79557EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA Translation: ABQ24444.1
RefSeqiWP_011937173.1, NC_009483.1

Genome annotation databases

EnsemblBacteriaiABQ24444; ABQ24444; Gura_0228
KEGGigur:Gura_0228

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA Translation: ABQ24444.1
RefSeqiWP_011937173.1, NC_009483.1

3D structure databases

ProteinModelPortaliA5GDA4
SMRiA5GDA4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351605.Gura_0228

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ24444; ABQ24444; Gura_0228
KEGGigur:Gura_0228

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

BioCyciGURA351605:G1G8X-229-MONOMER

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASSY_GEOUR
AccessioniPrimary (citable) accession number: A5GDA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 12, 2007
Last modified: October 10, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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