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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

Catalytic activityi

ATP + H2O + 4 H+(Side 1) = ADP + phosphate + 4 H+(Side 2).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei371Required for activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi170 – 177ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:7.1.2.2UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:Acry_1679
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
Proteomesi
  • UP000000245 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000550501 – 510ATP synthase subunit alphaAdd BLAST510

Proteomic databases

PRIDEiA5FZ52

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi349163.Acry_1679

Structurei

3D structure databases

ProteinModelPortaliA5FZ52
SMRiA5FZ52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDG Bacteria
COG0056 LUCA
HOGENOMiHOG000130111
KOiK02111
OMAiGNAQIKS
OrthoDBiPOG091H01QH

Family and domain databases

CDDicd01132 F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346 ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR000793 ATP_synth_asu_C
IPR038376 ATP_synth_asu_C_sf
IPR033732 ATP_synth_F1_a
IPR005294 ATP_synth_F1_asu
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF00306 ATP-synt_ab_C, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039088 F_ATPase_subunit_alpha, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00962 atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

A5FZ52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIRPAEISE ILKKQIASFD TETDVAETGQ VLSVGDGIAR VFGLANVMAG
60 70 80 90 100
EMVEFPNAGV QGMALNLEND NVGVVVFGDD KAIREGDTVT RTRRIVDVPV
110 120 130 140 150
GKGLLGRVVD ALGNPIDGKG PIEATERRLV ETKAPGIIPR KSVHEPMQTG
160 170 180 190 200
VKSIDALIPI GRGQRELVIG DRQTGKTAII VDTFINQKPL NAQDDESKKL
210 220 230 240 250
YCIYVAVGQK RSTVAQLVRT LEENGAMEYS IVIAATASEP APMQFLAPYT
260 270 280 290 300
GCAMGEYFRD NGMHALIVYD DLSKQAVAYR QMSLLLRRPP GREAYPGDVF
310 320 330 340 350
YLHSRLLERA AKMSDEFGAG SLTALPVIET QAGDISAYIP TNVISITDGQ
360 370 380 390 400
IFLETELFFK GIRPAVNVGN SVSRVGSAAQ IKAMKQVAGK IKLDLAQYRE
410 420 430 440 450
MAAFAQFASD LDASTQKLLA RGARLTELLK QPQFKPLPVE EQVVSIFVGT
460 470 480 490 500
RGYLDEVPVN RIGDFEAQLI SEMKARSPEI LDSIRNDREI KKETETKLVD
510
FVKSFASSFA
Length:510
Mass (Da):55,627
Last modified:June 12, 2007 - v1
Checksum:i05161409CCFBE667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA Translation: ABQ30884.1
RefSeqiWP_007423085.1, NC_009484.1

Genome annotation databases

EnsemblBacteriaiABQ30884; ABQ30884; Acry_1679
KEGGiacr:Acry_1679

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA Translation: ABQ30884.1
RefSeqiWP_007423085.1, NC_009484.1

3D structure databases

ProteinModelPortaliA5FZ52
SMRiA5FZ52
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349163.Acry_1679

Proteomic databases

PRIDEiA5FZ52

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ30884; ABQ30884; Acry_1679
KEGGiacr:Acry_1679

Phylogenomic databases

eggNOGiENOG4105CDG Bacteria
COG0056 LUCA
HOGENOMiHOG000130111
KOiK02111
OMAiGNAQIKS
OrthoDBiPOG091H01QH

Family and domain databases

CDDicd01132 F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346 ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR000793 ATP_synth_asu_C
IPR038376 ATP_synth_asu_C_sf
IPR033732 ATP_synth_F1_a
IPR005294 ATP_synth_F1_asu
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF00306 ATP-synt_ab_C, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039088 F_ATPase_subunit_alpha, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00962 atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATPA_ACICJ
AccessioniPrimary (citable) accession number: A5FZ52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: November 7, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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