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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 39C4-typeUniRule annotationAdd BLAST26
Nucleotide bindingi118 – 125ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:Acry_0918
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
Proteomesi
  • UP000000245 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001238141 – 418ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST418

Proteomic databases

PRIDEiA5FX05

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi349163.Acry_0918

Structurei

3D structure databases

ProteinModelPortaliA5FX05
SMRiA5FX05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 39C4-typeUniRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105CHN Bacteria
COG1219 LUCA
HOGENOMiHOG000010093
KOiK03544
OMAiDIMYDLP
OrthoDBiPOG091H01U4

Family and domain databases

Gene3Di3.30.50.30, 1 hit
HAMAPiMF_00175 ClpX, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004487 Clp_protease_ATP-bd_su_ClpX
IPR027417 P-loop_NTPase
IPR010603 Znf_CppX_C4
IPR038366 Znf_CppX_C4_sf
PANTHERiPTHR11262 PTHR11262, 2 hits
PfamiView protein in Pfam
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
PF06689 zf-C4_ClpX, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SM00994 zf-C4_ClpX, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00382 clpX, 1 hit

Sequencei

Sequence statusi: Complete.

A5FX05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKSGDSKN TLYCSFCGKS QHEVVKLIAG PTVFICNECV ELCMDIIRED
60 70 80 90 100
NRTHLVKTRD GVPTPREICK VLDDYVIGQD HAKRILSVAV HNHYKRLAHA
110 120 130 140 150
QKNNDIEIAK SNIMLVGPTG SGKTLLAQTL ARILDVPFTM ADATTLTEAG
160 170 180 190 200
YVGEDVENII LKLLQAADYN VERAQRGIVY IDEVDKISRK SDNPSITRDV
210 220 230 240 250
SGEGVQQALL KIMEGTVASV PPQGGRKHPQ QEFLQVDTTN ILFICGGAFA
260 270 280 290 300
GLEKIIAQRG KGSGIGFGAD VRDPTEQRTG AILREVEPED LLKFGLIPEF
310 320 330 340 350
IGRLPVVATL EDLDEAALIE ILTKPKNALV KQYGRLFEME GVKLNFTEDA
360 370 380 390 400
LKVVAARAIQ RKTGARGLRS IMENILLETM FDLPGLDSVE EVVINGEVAE
410
GRANPLFLHG KERAETGS
Length:418
Mass (Da):45,759
Last modified:June 12, 2007 - v1
Checksum:iCEB653ACCD3A1AFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA Translation: ABQ30137.1
RefSeqiWP_011941871.1, NC_009484.1

Genome annotation databases

EnsemblBacteriaiABQ30137; ABQ30137; Acry_0918
KEGGiacr:Acry_0918

Similar proteinsi

Entry informationi

Entry nameiCLPX_ACICJ
AccessioniPrimary (citable) accession number: A5FX05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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