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Protein

3-ketoacyl-CoA thiolase

Gene

fadA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Acyl-thioester intermediateUniRule annotation1
Active sitei343Proton acceptorUniRule annotation1
Active sitei373Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciVCHO345073:G1GU4-200-MONOMER
UniPathwayi
UPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
Acetyl-CoA acyltransferaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadAUniRule annotation
Ordered Locus Names:VC0395_A2533, VC395_0196
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000249 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003235561 – 3873-ketoacyl-CoA thiolaseAdd BLAST387

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Protein-protein interaction databases

STRINGi345073.VC0395_A2533

Structurei

3D structure databases

ProteinModelPortaliA5F464
SMRiA5F464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU Bacteria
COG0183 LUCA
HOGENOMiHOG000012239
KOiK00632
OMAiCGGTESM
OrthoDBiPOG091H0I7B

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
HAMAPiMF_01620 FadA, 1 hit
InterProiView protein in InterPro
IPR012805 FadA
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
TIGR02445 fadA, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A5F464-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTVVIVDCL RTPMGRSKGG AFRHQRAEDL SAHLMKGILA RNPQVNPKEI
60 70 80 90 100
EDIYWGCVQQ TLEQGFNVAR NAALLAGLPI EIGAVTVNRL CGSSMQALHD
110 120 130 140 150
AARAIMVGDA EICLVGGVEH MGHVPMTHGV DFHPGLSKNV AKAAGMMGLT
160 170 180 190 200
AEMLGKLHGI SRQQQDEFAA RSHARAHAAT LEGRFKNEIL PTEGHAADGT
210 220 230 240 250
LFTLDYDEVI RPETTVAGLA ELRPVFDPAN GTVTAGTSSA LSDGASAMLV
260 270 280 290 300
MSEQKAKALG LTIRARIKAM AVAGCDPSIM GYGPVPATHK ALKRAGLTMQ
310 320 330 340 350
DMDVVELNEA FAAQSLPCAK DLGLLDMMDD KVNLNGGAIA LGHPLGCSGT
360 370 380
RISTTLINLM EAKDAKYGLA TMCIGLGQGI ATIFERP
Length:387
Mass (Da):40,828
Last modified:June 12, 2007 - v1
Checksum:iA02AD9651DDC94CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000627 Genomic DNA Translation: ABQ20531.1
CP001235 Genomic DNA Translation: ACP08223.1
RefSeqiWP_001099261.1, NC_012582.1

Genome annotation databases

EnsemblBacteriaiABQ20531; ABQ20531; VC0395_A2533
ACP08223; ACP08223; VC395_0196
KEGGivco:VC0395_A2533
vcr:VC395_0196
PATRICifig|345073.21.peg.185

Similar proteinsi

Entry informationi

Entry nameiFADA_VIBC3
AccessioniPrimary (citable) accession number: A5F464
Secondary accession number(s): C3M344
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 12, 2007
Last modified: February 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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