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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei188PROSITE-ProRule annotation1
Active sitei399PROSITE-ProRule annotation1
Active sitei457PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

ESTHERilodel-kex1 Carboxypeptidase_S10
MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:LELG_05440
OrganismiLodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
Taxonomic identifieri379508 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeLodderomyces
Proteomesi
  • UP000001996 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 554LumenalSequence analysisAdd BLAST535
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Topological domaini576 – 702CytoplasmicSequence analysisAdd BLAST127

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041192420 – 702Pheromone-processing carboxypeptidase KEX1Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi379508.XP_001523214.1

Structurei

3D structure databases

ProteinModelPortaliA5E751
SMRiA5E751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
InParanoidiA5E751
KOiK01288
OMAiNEIYFAG
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5E751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLISSIYTIC LFIITSVLAI PPKEGSDSDP AKQYLVTDLP GLHENIDDDF
60 70 80 90 100
KPIMYAGQVE LFPENNTMYF FWKFTDPKKS TDSAYSKRSI FWLNGGPGCS
110 120 130 140 150
SMDGALLETG PFRINQDEKV VMNNGSWHKA GDVVYVDQPA GTGFSYTDQG
160 170 180 190 200
KWLHDLPDMA FYFLKFMEKY YEIYPEEIDN DIYFAGESYA GQYIPYIADA
210 220 230 240 250
ILKRNAKLEE GQKKYNLKSL LIGNGWVSPN EQSLSYLPFF IENKLIDKEN
260 270 280 290 300
PRWMELLGDH EKCQRIVDGI DSKFDDKELN PAELDSNLCE GILTKLLSAT
310 320 330 340 350
VNGDGADDDQ RCINMYDFTL RDSWPGCGIN WPFELKYVTP FLRNDEVKHD
360 370 380 390 400
LNLRVMKTWR ECSGRVGRNF NAQHSFPSVH LLPDLLKQVP IILFSGMNDI
410 420 430 440 450
ICNSKGTLQY VLKLNWNGRK GFENPDAKLD WIHDDKKVGY VIQERNLTFI
460 470 480 490 500
DIYNSSHMVP YDLPEVSRAL LEIATNNYDI RDVDETNQNL VTYPLGVQKK
510 520 530 540 550
GKIEVNPPST PSSNDDSTTS ETSDSQPDTV SSAGTSAEAE TETEAEPTVN
560 570 580 590 600
KVARLIQLAV ILIVIWGLYL LYASWRARPS PIMKKNGGNG RKKNVQWADQ
610 620 630 640 650
LSRFEEEADA SQLKGFFAKT MDRFRTTEGQ GSYARAQSDD YIDDIELGEG
660 670 680 690 700
IGETQLDDFI IGSDDEREGE LEQPTHKSGN MDTDTNKNMK NSSNESKNKN

TV
Length:702
Mass (Da):79,550
Last modified:June 12, 2007 - v1
Checksum:iC72913D44E37B44D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH981533 Genomic DNA Translation: EDK47259.1
RefSeqiXP_001523214.1, XM_001523164.1

Genome annotation databases

EnsemblFungiiEDK47259; EDK47259; LELG_05440
GeneIDi5230460
KEGGilel:LELG_05440

Similar proteinsi

Entry informationi

Entry nameiKEX1_LODEL
AccessioniPrimary (citable) accession number: A5E751
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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