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Entry version 68 (10 Apr 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Structural maintenance of chromosomes protein

Gene

PGUG_00290

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structural maintenance of chromosomes proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PGUG_00290Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri294746 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001997 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4929.XP_001486913.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A5DAI5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini568 – 686SMC hingeInterPro annotationAdd BLAST119

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili299 – 329Sequence analysisAdd BLAST31
Coiled coili362 – 382Sequence analysisAdd BLAST21
Coiled coili390 – 410Sequence analysisAdd BLAST21
Coiled coili453 – 480Sequence analysisAdd BLAST28
Coiled coili531 – 551Sequence analysisAdd BLAST21
Coiled coili758 – 792Sequence analysisAdd BLAST35
Coiled coili800 – 834Sequence analysisAdd BLAST35
Coiled coili874 – 943Sequence analysisAdd BLAST70
Coiled coili1066 – 1093Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0018 Eukaryota
COG1196 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A5DAI5

KEGG Orthology (KO)

More...
KOi
K06636

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMEAIVV

Database of Orthologous Groups

More...
OrthoDBi
326079at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR024704 SMC
IPR028468 Smc1
IPR010935 SMC_hinge
IPR036277 SMC_hinge_sf

The PANTHER Classification System

More...
PANTHERi
PTHR18937:SF12 PTHR18937:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06470 SMC_hinge, 1 hit
PF02463 SMC_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005719 SMC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00968 SMC_hinge, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF75553 SSF75553, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5DAI5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEPYAPRRS AQTPTTPDQI GYPPIHRTQI QINATRRRAQ NTSFTMGRLV
60 70 80 90 100
GLELYNFKSY RGTCKVGFGD SFFTSIIGPN GAGKSNMMDA ISFVLGVNSS
110 120 130 140 150
QLRSRNLQDL IYRGRIGGDS AADTSFEHSN PTSAYVKAIY EKDDGSQLEL
160 170 180 190 200
KRTIGSSGNG DYKINNKNVT AYQYSMVLKE ENILIKARNF LVFQGDVEQI
210 220 230 240 250
ASQSPRDLAQ LIETISGSGE LKPEYDKLKD EYDAAHEFTT QVFSHKKTLN
260 270 280 290 300
SESRQYKEQL AEKETFETKL QERVDITKLL HLYKLYHNEQ KHAQISSEIG
310 320 330 340 350
SKTEEIAKLE SQIEEKKELY DKLVSAQAKD VLRQKKFSSQ IASLVKNIES
360 370 380 390 400
ERKNLIPIDA SKRSLMAKVN QLKSKQKELT SEMTSRKKAV TNLEKQLKDS
410 420 430 440 450
ERLYKEFQDK ISSASNIKVS PQCQQDYESL RAEYLASGGA QLEEKLSLVH
460 470 480 490 500
NDQEALEVTL TNLRRQLKTA ESRKEKLEIT IETELSYKRD EIASRISDVQ
510 520 530 540 550
GDISSAEVSR SKLISQKEEL SRQELDLNSK LRDVLLKLDE LSSRRRESNK
560 570 580 590 600
QKALRENVAM LKRHFPKGAI RGQLYDLVRP TNQKYEEALS TTLGRNFDSI
610 620 630 640 650
VVETATIAHK CIEILKERRS GVATFIPLDS VTSDPINLSH LRSLHPSARP
660 670 680 690 700
GIDIVEYDDP ELEQAIRYVV EDTIVVDDIN LARSLKWGGG SSLKNKLVTL
710 720 730 740 750
DGSVISKSGI MSGGRQKERS SSFVQWDKNE WNKLSQVKEE LAVKLASLSE
760 770 780 790 800
QRPKEMEIND LAEKVIALED NIQLLTGQRE AIERAIQDKK SEIEYQDKLI
810 820 830 840 850
ADVNTSIEEK MQLKQEIEEE INSCEEEVTS LQNKIYDGFC KKYSFANGIT
860 870 880 890 900
DYEDKYGSAL RSRAKERMQY SKAISTLKNK LEFDQESVEE TQNRLDDLAE
910 920 930 940 950
RILKIEGQIV EKLDEKSLKE SDVDKLEAEL EVLQSEKDQF DTQVASKTKA
960 970 980 990 1000
AEEIDSQITD IKDELASESR AVAGMEESLL NVDMERISVL KSCKIDGINV
1010 1020 1030 1040 1050
PLKDGLLETF EIDETMDHIS DHIYSIEVDY DLLQKRLRDN YSYKVEAEMA
1060 1070 1080 1090 1100
AKIESITEEL EQLAPNAKAT ERLKEVEKKL KSYDRDHTKA RQAENKAYEK
1110 1120 1130 1140 1150
FKKVTENRLR MFMTTFNHLA EKIDFIYKEL TRSSSSPFGG VASLTLEDEE
1160 1170 1180 1190 1200
EPYNAGVKYH AMPPSKRFRD MDLLSGGEKT MAALALLFAI HSYQPSPFFV
1210 1220 1230 1240 1250
LDEVDAALDV ANVNRIATYI KNHAGPNFQF IVISLKNTLF EKSDALVGIY

REQQGQ
Length:1,256
Mass (Da):142,808
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B0D49460197FCF5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH408155 Genomic DNA Translation: EDK36192.2

NCBI Reference Sequences

More...
RefSeqi
XP_001486913.1, XM_001486863.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EDK36192; EDK36192; PGUG_00290

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5129302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pgu:PGUG_00290

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408155 Genomic DNA Translation: EDK36192.2
RefSeqiXP_001486913.1, XM_001486863.1

3D structure databases

ProteinModelPortaliA5DAI5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4929.XP_001486913.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEDK36192; EDK36192; PGUG_00290
GeneIDi5129302
KEGGipgu:PGUG_00290

Phylogenomic databases

eggNOGiKOG0018 Eukaryota
COG1196 LUCA
InParanoidiA5DAI5
KOiK06636
OMAiYMEAIVV
OrthoDBi326079at2759

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR024704 SMC
IPR028468 Smc1
IPR010935 SMC_hinge
IPR036277 SMC_hinge_sf
PANTHERiPTHR18937:SF12 PTHR18937:SF12, 1 hit
PfamiView protein in Pfam
PF06470 SMC_hinge, 1 hit
PF02463 SMC_N, 1 hit
PIRSFiPIRSF005719 SMC, 1 hit
SMARTiView protein in SMART
SM00968 SMC_hinge, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75553 SSF75553, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5DAI5_PICGU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5DAI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: July 22, 2008
Last modified: April 10, 2019
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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