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Entry version 61 (12 Aug 2020)
Sequence version 1 (12 Jun 2007)
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Protein
Submitted name:

WNK1 protein

Gene

WNK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
WNK1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

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PeptideAtlasi
A5D8Z4

PRoteomics IDEntifications database

More...
PRIDEi
A5D8Z4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A5D8Z4, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 275DisorderedSequence analysisAdd BLAST275
Regioni612 – 631DisorderedSequence analysisAdd BLAST20
Regioni888 – 945DisorderedSequence analysisAdd BLAST58
Regioni1021 – 1103DisorderedSequence analysisAdd BLAST83
Regioni1149 – 1224DisorderedSequence analysisAdd BLAST76
Regioni1256 – 1351DisorderedSequence analysisAdd BLAST96
Regioni1487 – 1507DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1228 – 1248Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18PolyampholyteSequence analysisAdd BLAST18
Compositional biasi19 – 58PolarSequence analysisAdd BLAST40
Compositional biasi65 – 200PolarSequence analysisAdd BLAST136
Compositional biasi210 – 247PolarSequence analysisAdd BLAST38
Compositional biasi251 – 271BasicSequence analysisAdd BLAST21
Compositional biasi888 – 903PolarSequence analysisAdd BLAST16
Compositional biasi1026 – 1040PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1041 – 1061PolarSequence analysisAdd BLAST21
Compositional biasi1077 – 1103PolarSequence analysisAdd BLAST27
Compositional biasi1185 – 1217PolarSequence analysisAdd BLAST33
Compositional biasi1288 – 1351PolarSequence analysisAdd BLAST64

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K08867

Database of Orthologous Groups

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OrthoDBi
27514at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A5D8Z4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GAAEKQSKKK KKQEESSLKQ QVEQSSASQT GIKQLPSAST GIPTASTTSA
60 70 80 90 100
SVSTQVEPEE PEADQHQQLQ YQQPSISVLS DGTVDSGQGS SVFTESRVSS
110 120 130 140 150
QQTVSYGSQH EQAHSTGTVP GHIPSTVQAQ SQPHGVYPPS SVQQGIQQTA
160 170 180 190 200
PPQQTVQYSL SQTSTSSEAT TAQPVSQPQA PQVLPQVSAG KQSTQGVSQV
210 220 230 240 250
APAEPVAVAQ PQATQPTTLA SSVDSAHSDV ASGMSDGNEN VPSSSGRHEG
260 270 280 290 300
RTTKRHYRKS VRSRSRHEKT SRPKLRILNV SNKGDRVVEC QLETHNRKMV
310 320 330 340 350
TFKFDLDGDN PEEIATIMVN NDFILAIERE SFVDQVREII EKADEMLSED
360 370 380 390 400
VSVEPEGDQG LESLQGKDDY GFSGSQKLEG EFKQPIPASS MPQQIGIPTS
410 420 430 440 450
SLTQVVHSAG RRFIVSPVPE SRLRESKVFP SEITDTVAAS TAQSPGMNLS
460 470 480 490 500
HSASSLSLQQ AFSELRRAQM TEGPNTAPPN FSHTGPTFPV VPPFLSSIAG
510 520 530 540 550
VPTTAAATAP VPATSSPPND ISTSVIQSEV TVPTEEGIAG VATSTGVVTS
560 570 580 590 600
GGLPIPPVSE SPVLSSVVSS ITIPAVVSIS TTSPSLQVPT STSEIVVSST
610 620 630 640 650
ALYPSVTVSA TSASAGGSTA TPGPKPPAVV SQQAAGSTTV GATLTSVSTT
660 670 680 690 700
TSFPSTASQL SIQLSSSTST PTLAETVVVS AHSLDKTSHS STTGLAFSLS
710 720 730 740 750
APSSSSSPGA GVSSYISQPG GLHPLVIPSV IASTPILPQA AGPTSTPLLP
760 770 780 790 800
QVPSIPPLVQ PVANVPAVQQ TLIHSQPQPA LLPNQPHTHC PEVDSDTQPK
810 820 830 840 850
APGIDDIKTL EEKLRSLFSE HSSSGAQHAS VSLETSLVIE STVTPGIPTT
860 870 880 890 900
AVAPSKLLTS TTSTCLPPTN LPLGTVALPV TPVVTPGQVS TPVSTTTSGV
910 920 930 940 950
KPGTAPSKPP LTKAPVLPVG TELPAGTLPS EQLPPFPGPS LTQSQQPLED
960 970 980 990 1000
LDAQLRRTLS PEMITVTSAV GPVSMAAPTA ITEAGTQPQK GVSQVKEGPV
1010 1020 1030 1040 1050
LATSSGAGVF KMGRFQVSVA ADGAQKEGKN KSEDAKSVHF ESSTSESSVL
1060 1070 1080 1090 1100
SSSSPESTLV KPEPNGITIP GISSDVPESA HKTTASEAKS DTGQPTKVGR
1110 1120 1130 1140 1150
FQVTTTANKV GRFSVSKTED KITDTKKEGP VASPPFMDLE QAVLPAVIPK
1160 1170 1180 1190 1200
KEKPELSEPS HLNGPSSDPE AAFLSRDVDD GSGSPHSPHQ LSSKSLPSQN
1210 1220 1230 1240 1250
LSQSLSNSFN SSYMSSDNES DIEDEDLKLE LRRLRDKHLK EIQDLQSRQK
1260 1270 1280 1290 1300
HEIESLYTKL GKVPPAVIIP PAAPLSGRRR RPTKSKGSKS SRSSSLGNKS
1310 1320 1330 1340 1350
PQLSGNLSGQ SAASVLHPQQ TLHPPGNIPE SGQNQLLQPL KPSPSSDNLY
1360 1370 1380 1390 1400
SAFTSDGAIS VPSLSAPGQG TSSTNTVGAT VNSQAAQAQP PAMTSSRKGT
1410 1420 1430 1440 1450
FTDDLHKLVD NWARDAMNLS GRRGSKGHMN YEGPGMARKF SAPGQLCISM
1460 1470 1480 1490 1500
TSNLGGSAPI SAASATSLGH FTKSMCPPQQ YGFPATPFGA QWSGTGGPAP
1510 1520 1530
QPLGQFQPVG TASLQNFNIS NLQKSISNPP GSNLRTT
Length:1,537
Mass (Da):159,519
Last modified:June 12, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE87300B229B53FE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC141881 mRNA Translation: AAI41882.1

NCBI Reference Sequences

More...
RefSeqi
NP_055638.2, NM_014823.2
NP_061852.3, NM_018979.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65125

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141881 mRNA Translation: AAI41882.1
RefSeqiNP_055638.2, NM_014823.2
NP_061852.3, NM_018979.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA5D8Z4
PRIDEiA5D8Z4

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
65125

Genome annotation databases

GeneIDi65125
KEGGihsa:65125

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65125

Phylogenomic databases

KOiK08867
OrthoDBi27514at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
65125, 530 hits in 912 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WNK1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65125

Gene expression databases

GenevisibleiA5D8Z4, HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5D8Z4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5D8Z4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: August 12, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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