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Entry version 114 (22 Apr 2020)
Sequence version 2 (30 Nov 2010)
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Protein

Vacuolar protein sorting-associated protein 37C

Gene

VPS37C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-162588 Budding and maturation of HIV virion
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-9610379 HCMV Late Events
R-HSA-9615710 Late endosomal microautophagy

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
A5D8V6 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37C
Short name:
hVps37C
Alternative name(s):
ESCRT-I complex subunit VPS37C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS37C
Synonyms:PML39
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:26097 VPS37C

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610038 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A5D8V6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55048

Open Targets

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OpenTargetsi
ENSG00000167987

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142670617

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A5D8V6 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VPS37C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003121981 – 355Vacuolar protein sorting-associated protein 37CAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by TBK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A5D8V6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A5D8V6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
A5D8V6

MaxQB - The MaxQuant DataBase

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MaxQBi
A5D8V6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A5D8V6

PRoteomics IDEntifications database

More...
PRIDEi
A5D8V6

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
712

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A5D8V6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A5D8V6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167987 Expressed in secondary oocyte and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A5D8V6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A5D8V6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167987 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry.

Interacts with TSG101, VPS28, MVB12A and MVB12B.

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry.

Interacts with HGS and STAM2.

Interacts with CEP55.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

A5D8V6
With#Exp.IntAct
G4XUV33EBI-2559305,EBI-10177989
AARD [Q4LEZ3]3EBI-2559305,EBI-5463075
ABHD11 - isoform 4 [Q8NFV4-4]3EBI-2559305,EBI-12318443
ASCL3 [Q9NQ33]3EBI-2559305,EBI-12108222
BAG4 [O95429]3EBI-2559305,EBI-2949658
BIRC7 [Q96CA5]3EBI-2559305,EBI-517623
C1orf94 [Q6P1W5]6EBI-2559305,EBI-946029
CEP55 [Q53EZ4]8EBI-2559305,EBI-747776
CRX [O43186]3EBI-2559305,EBI-748171
DAZAP2 [Q15038]6EBI-2559305,EBI-724310
DCTN3 - isoform 2 [O75935-2]3EBI-2559305,EBI-12091947
DDIT3 [P35638]3EBI-2559305,EBI-742651
DDIT3 - isoform 2 [P35638-2]3EBI-2559305,EBI-10173632
DYDC1 [Q8WWB3]3EBI-2559305,EBI-740680
EYA2 - isoform 2 [O00167-2]3EBI-2559305,EBI-12807776
FAM168A [Q92567]3EBI-2559305,EBI-7957930
FAM168B - isoform 2 [A1KXE4-2]3EBI-2559305,EBI-12193763
FAM22F [B7ZLH0]3EBI-2559305,EBI-10220102
FCHSD2 - isoform 3 [O94868-3]3EBI-2559305,EBI-11958845
FOXI1 - isoform 2 [Q12951-2]6EBI-2559305,EBI-12018822
FUBP1 - isoform 2 [Q96AE4-2]3EBI-2559305,EBI-12121668
GOLGA2 [Q08379]3EBI-2559305,EBI-618309
GPS2 [Q13227]3EBI-2559305,EBI-713355
GRB2 [P62993]3EBI-2559305,EBI-401755
HAUS1 [Q96CS2]3EBI-2559305,EBI-2514791
HELT [A0A087WSW0]3EBI-2559305,EBI-12057631
HGS [O14964]3EBI-2559305,EBI-740220
HNRNPF [P52597]3EBI-2559305,EBI-352986
HNRNPUL1 [Q9BUJ2]3EBI-2559305,EBI-1018153
ILF3 - isoform 6 [Q12906-6]3EBI-2559305,EBI-12904528
KLF1 [Q13351]3EBI-2559305,EBI-8284732
KRT27 [Q7Z3Y8]3EBI-2559305,EBI-3044087
KRT33B [Q14525]3EBI-2559305,EBI-1049638
KRTAP15-1 [Q3LI76]3EBI-2559305,EBI-11992140
KRTAP19-5 [Q3LI72]3EBI-2559305,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-2559305,EBI-12805508
KRTAP19-7 [Q3SYF9]3EBI-2559305,EBI-10241353
KRTAP6-1 [Q3LI64]3EBI-2559305,EBI-12111050
KRTAP6-2 [Q3LI66]5EBI-2559305,EBI-11962084
KRTAP7-1 [Q8IUC3]3EBI-2559305,EBI-18394498
LAGE3 [Q14657]3EBI-2559305,EBI-1052105
LASP1 - isoform 2 [Q14847-2]3EBI-2559305,EBI-9088686
MAPK1IP1L [Q8NDC0]6EBI-2559305,EBI-741424
METTL27 [Q8N6F8]3EBI-2559305,EBI-8487781
NUP54 [Q7Z3B4]3EBI-2559305,EBI-741048
P4HA3 [Q7Z4N8]3EBI-2559305,EBI-10181968
PAX9 [P55771]3EBI-2559305,EBI-12111000
PDCD6 [O75340]6EBI-2559305,EBI-352915
PEF1 [Q9UBV8]3EBI-2559305,EBI-724639
PKNOX1 [P55347]4EBI-2559305,EBI-1373569
PKNOX1 [Q96I87]3EBI-2559305,EBI-10173774
PKNOX2 [Q96KN3]5EBI-2559305,EBI-2692890
PLA2G10 [O15496]3EBI-2559305,EBI-726466
PLEKHG4 [Q58EX7]3EBI-2559305,EBI-949255
PLSCR1 [O15162]3EBI-2559305,EBI-740019
POLR2J [P52435]3EBI-2559305,EBI-394753
POLR2J3 [Q9H1A7]3EBI-2559305,EBI-12818681
POU2AF1 [Q16633]3EBI-2559305,EBI-943588
PRR20D [P86480]3EBI-2559305,EBI-12754095
PSMA3 [P25788]3EBI-2559305,EBI-348380
RAMAC [Q9BTL3]3EBI-2559305,EBI-744023
RBPMS [Q93062]3EBI-2559305,EBI-740322
RBPMS - isoform C [Q93062-3]3EBI-2559305,EBI-740343
RBPMS2 [Q6ZRY4]3EBI-2559305,EBI-11987469
RFX6 [Q8HWS3]3EBI-2559305,EBI-746118
RIBC1 [Q8N443]6EBI-2559305,EBI-10265323
RINT1 [Q6NUQ1]3EBI-2559305,EBI-726876
RPRD1B [Q9NQG5]3EBI-2559305,EBI-747925
RUNX1 - isoform AML-1G [Q01196-8]3EBI-2559305,EBI-12001422
SH3GL1 [Q6FGM0]3EBI-2559305,EBI-10173690
SH3GL1 [Q99961]3EBI-2559305,EBI-697911
SH3RF2 [Q8TEC5]3EBI-2559305,EBI-2130111
SORBS2 [O94875]3EBI-2559305,EBI-311323
SORBS2 - isoform 10 [O94875-10]3EBI-2559305,EBI-12037893
SORBS3 [O60504]6EBI-2559305,EBI-741237
SPAG8 - isoform 2 [Q99932-2]3EBI-2559305,EBI-11959123
STAM2 [O75886]6EBI-2559305,EBI-373258
STH [Q8IWL8]3EBI-2559305,EBI-12843506
TACC3 [Q9Y6A5]3EBI-2559305,EBI-2554984
TFAP2D [Q7Z6R9]3EBI-2559305,EBI-11952651
TFG [Q92734]6EBI-2559305,EBI-357061
TFIP11 [Q9UBB9]3EBI-2559305,EBI-1105213
TIAL1 - isoform 2 [Q01085-2]3EBI-2559305,EBI-11064654
TLE5 [Q08117]3EBI-2559305,EBI-717810
TLE5 - isoform 2 [Q08117-2]3EBI-2559305,EBI-11741437
TSC1 [Q86WV8]3EBI-2559305,EBI-12806590
TSG101 [Q99816]6EBI-2559305,EBI-346882
UBAP2 [Q5T6F2]3EBI-2559305,EBI-2514383
UFSP1 [Q6NVU6]3EBI-2559305,EBI-12068150
WDYHV1 [Q96HA8]6EBI-2559305,EBI-741158
WWOX - isoform 5 [Q9NZC7-5]3EBI-2559305,EBI-12040603
WWP2 [O00308]6EBI-2559305,EBI-743923
XIAP [P98170]7EBI-2559305,EBI-517127
YTHDF1 [Q9BYJ9]3EBI-2559305,EBI-1051237
ZMAT5 [Q9UDW3]3EBI-2559305,EBI-7850213
ZMYND12 [Q9H0C1]3EBI-2559305,EBI-12030590

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120371, 62 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
A5D8V6

Protein interaction database and analysis system

More...
IntActi
A5D8V6, 99 interactors

Molecular INTeraction database

More...
MINTi
A5D8V6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301765

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A5D8V6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A5D8V6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 167VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi171 – 353Pro-richAdd BLAST183

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3270 Eukaryota
ENOG4111UJN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183012

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_067118_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A5D8V6

KEGG Orthology (KO)

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KOi
K12185

Identification of Orthologs from Complete Genome Data

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OMAi
TCPYPTQ

Database of Orthologous Groups

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OrthoDBi
1197293at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A5D8V6

TreeFam database of animal gene trees

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TreeFami
TF321840

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR009851 Mod_r
IPR037859 Vps37

The PANTHER Classification System

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PANTHERi
PTHR13678 PTHR13678, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07200 Mod_r, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF140111 SSF140111, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51314 VPS37_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A5D8V6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METLKDKTLQ ELEELQNDSE AIDQLALESP EVQDLQLERE MALATNRSLA
60 70 80 90 100
ERNLEFQGPL EISRSNLSDR YQELRKLVER CQEQKAKLEK FSSALQPGTL
110 120 130 140 150
LDLLQVEGMK IEEESEAMAE KFLEGEVPLE TFLENFSSMR MLSHLRRVRV
160 170 180 190 200
EKLQEVVRKP RASQELAGDA PPPRPPPPVR PVPQGTPPVV EEQPQPPLAM
210 220 230 240 250
PPYPLPYSPS PSLPVGPTAH GALPPAPFPV VSQPSFYSGP LGPTYPAAQL
260 270 280 290 300
GPRGAAGYSW SPQRSMPPRP GYPGTPMGAS GPGYPLRGGR APSPGYPQQS
310 320 330 340 350
PYPATGGKPP YPIQPQLPSF PGQPQPSVPL QPPYPPGPAP PYGFPPPPGP

AWPGY
Length:355
Mass (Da):38,659
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DE18F0E4C7C7E2E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4Q5F5H4Q5_HUMAN
Vacuolar protein sorting-associated...
VPS37C
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD38936 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037451182V → D1 PublicationCorresponds to variant dbSNP:rs2232142Ensembl.1
Natural variantiVAR_037452198L → S2 PublicationsCorresponds to variant dbSNP:rs754382Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL834261 mRNA Translation: CAD38936.1 Different initiation.
AP000437 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73925.1
BC141827 mRNA Translation: AAI41828.1
BC142702 mRNA Translation: AAI42703.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31573.1

NCBI Reference Sequences

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RefSeqi
NP_060436.4, NM_017966.4
XP_005274134.1, XM_005274077.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301765; ENSP00000301765; ENSG00000167987

Database of genes from NCBI RefSeq genomes

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GeneIDi
55048

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55048

UCSC genome browser

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UCSCi
uc001nqv.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834261 mRNA Translation: CAD38936.1 Different initiation.
AP000437 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73925.1
BC141827 mRNA Translation: AAI41828.1
BC142702 mRNA Translation: AAI42703.1
CCDSiCCDS31573.1
RefSeqiNP_060436.4, NM_017966.4
XP_005274134.1, XM_005274077.3

3D structure databases

SMRiA5D8V6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120371, 62 interactors
CORUMiA5D8V6
IntActiA5D8V6, 99 interactors
MINTiA5D8V6
STRINGi9606.ENSP00000301765

Protein family/group databases

MoonDBiA5D8V6 Predicted

PTM databases

iPTMnetiA5D8V6
PhosphoSitePlusiA5D8V6

Polymorphism and mutation databases

BioMutaiVPS37C

Proteomic databases

EPDiA5D8V6
jPOSTiA5D8V6
MassIVEiA5D8V6
MaxQBiA5D8V6
PaxDbiA5D8V6
PRIDEiA5D8V6
ProteomicsDBi712

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28060 148 antibodies

Genome annotation databases

EnsembliENST00000301765; ENSP00000301765; ENSG00000167987
GeneIDi55048
KEGGihsa:55048
UCSCiuc001nqv.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55048
DisGeNETi55048

GeneCards: human genes, protein and diseases

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GeneCardsi
VPS37C
HGNCiHGNC:26097 VPS37C
HPAiENSG00000167987 Low tissue specificity
MIMi610038 gene
neXtProtiNX_A5D8V6
OpenTargetsiENSG00000167987
PharmGKBiPA142670617

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
GeneTreeiENSGT00950000183012
HOGENOMiCLU_067118_0_0_1
InParanoidiA5D8V6
KOiK12185
OMAiTCPYPTQ
OrthoDBi1197293at2759
PhylomeDBiA5D8V6
TreeFamiTF321840

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-9610379 HCMV Late Events
R-HSA-9615710 Late endosomal microautophagy

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VPS37C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55048
PharosiA5D8V6 Tbio

Protein Ontology

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PROi
PR:A5D8V6
RNActiA5D8V6 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167987 Expressed in secondary oocyte and 224 other tissues
ExpressionAtlasiA5D8V6 baseline and differential
GenevisibleiA5D8V6 HS

Family and domain databases

InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP37C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5D8V6
Secondary accession number(s): Q8N3K4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 30, 2010
Last modified: April 22, 2020
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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