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Protein
Submitted name:

Tnfrsf21 protein

Gene

tnfrsf21

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Tnfrsf21 proteinImported
Gene namesi
Name:tnfrsf21Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030131-5971 tnfrsf21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500268095424 – 637Sequence analysisAdd BLAST614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 93PROSITE-ProRule annotation
Disulfide bondi100 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Structurei

3D structure databases

ProteinModelPortaliA5D8S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 118TNFR-CysInterPro annotationAdd BLAST42
Repeati77 – 118TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini402 – 485DeathInterPro annotationAdd BLAST84

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IHQ6 Eukaryota
ENOG410YYKW LUCA
HOGENOMiHOG000136852
HOVERGENiHBG054218
KOiK05157

Family and domain databases

CDDicd08778 Death_TNFRSF21, 1 hit
cd10583 TNFRSF21, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022330 TNFR_21
IPR034037 TNFRSF21_death
IPR034034 TNFRSF21_N
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 1 hit
PRINTSiPR01971 TNFACTORR21
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5D8S6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGKMSLIWS LTLLLTVVGD VLTHTLTPIP TTEKPLSPRH YHHIDPATGN
60 70 80 90 100
KLVCDKCPAG TYVSFHCTEA SVRECSPCPD GTFTRGENGV QQCHRCQRRC
110 120 130 140 150
QAPFIEKTPC TSTTDRLCVC PPGSFSQDGK CQRHSSCLPG WGVRKRGSET
160 170 180 190 200
EDVRCQPCQR GTFSAITSDS LRCQTHTDCP ALGLTLLIKG TKKTDNVCGP
210 220 230 240 250
NPASSVPVLL GEASVSTVSS TESAYRASTA VLPAADIQDE AEPVFSSTDM
260 270 280 290 300
ALGAQNFPTT TAYPEAIDKD GGLLIAATQD LPKSKLKLTL SRDPQLSNHQ
310 320 330 340 350
GVESISESKA QGLGYRPIRR GAPRPSSHKH FDINEHLPWM IVLLLLLVLV
360 370 380 390 400
VIVVCSVKRS SRVLKKGPRQ DPSSIMEKAI HKKPSSPAQT KERWIYYSNG
410 420 430 440 450
QGVDILKLVA AQIGSQWIDL YKSLASATER EVAAFSNGYT ADHERAYAAL
460 470 480 490 500
QHWTIRDSDA NLAKLINALH RQRRIDVVDK IRSVMEDNPQ VDLNKLMTAV
510 520 530 540 550
NVSHCLSPSH KPLESPGVAV EQSPMERSRG FFPDESEPLL RCDSTSSKDS
560 570 580 590 600
ALSRTGSFIT KEKKDTVLRQ VRLDPCDLQP IFDDMLHILN PDELHVIEEI
610 620 630
PMAEDKLDRL FEIAGVKSQE ASQTLLDSVY SHLPDLL
Length:637
Mass (Da):70,026
Last modified:June 12, 2007 - v1
Checksum:i011C995A401E2EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141795 mRNA Translation: AAI41796.1
RefSeqiNP_001036153.2, NM_001042688.2
UniGeneiDr.108925

Genome annotation databases

GeneIDi564874
KEGGidre:564874

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141795 mRNA Translation: AAI41796.1
RefSeqiNP_001036153.2, NM_001042688.2
UniGeneiDr.108925

3D structure databases

ProteinModelPortaliA5D8S6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi564874
KEGGidre:564874

Organism-specific databases

CTDi27242
ZFINiZDB-GENE-030131-5971 tnfrsf21

Phylogenomic databases

eggNOGiENOG410IHQ6 Eukaryota
ENOG410YYKW LUCA
HOGENOMiHOG000136852
HOVERGENiHBG054218
KOiK05157

Family and domain databases

CDDicd08778 Death_TNFRSF21, 1 hit
cd10583 TNFRSF21, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022330 TNFR_21
IPR034037 TNFRSF21_death
IPR034034 TNFRSF21_N
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 1 hit
PRINTSiPR01971 TNFACTORR21
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA5D8S6_DANRE
AccessioniPrimary (citable) accession number: A5D8S6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: November 7, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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