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Protein

Fat storage-inducing transmembrane protein 1

Gene

FITM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in lipid droplet accumulation.1 Publication

GO - Biological processi

  • lipid droplet organization Source: BHF-UCL
  • lipid storage Source: InterPro
  • phospholipid biosynthetic process Source: GO_Central
  • positive regulation of sequestering of triglyceride Source: BHF-UCL

Enzyme and pathway databases

ReactomeiR-HSA-8964572 Lipid particle organization

Names & Taxonomyi

Protein namesi
Recommended name:
Fat storage-inducing transmembrane protein 1
Alternative name(s):
Fat-inducing protein 1
Gene namesi
Name:FITM1
Synonyms:FIT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139914.6
HGNCiHGNC:33714 FITM1
MIMi612028 gene
neXtProtiNX_A5D6W6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 54ExtracellularSequence analysisAdd BLAST15
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 94CytoplasmicSequence analysisAdd BLAST19
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 187ExtracellularSequence analysisAdd BLAST72
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 220CytoplasmicSequence analysisAdd BLAST12
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 249ExtracellularSequence analysis8
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 292CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi161247
OpenTargetsiENSG00000139914
PharmGKBiPA165478932

Polymorphism and mutation databases

BioMutaiFITM1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195751 – 292Fat storage-inducing transmembrane protein 1Add BLAST292

Proteomic databases

PaxDbiA5D6W6
PRIDEiA5D6W6
ProteomicsDBi707
708 [A5D6W6-2]

PTM databases

iPTMnetiA5D6W6
PhosphoSitePlusiA5D6W6

Expressioni

Tissue specificityi

Primarily expressed in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000139914 Expressed in 85 organ(s), highest expression level in muscle of leg
GenevisibleiA5D6W6 HS

Organism-specific databases

HPAiHPA019842

Interactioni

Protein-protein interaction databases

BioGridi127777, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliA5D6W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FIT family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3750 Eukaryota
ENOG4111CNJ LUCA
GeneTreeiENSGT00530000063693
HOGENOMiHOG000112594
InParanoidiA5D6W6
OMAiSGWGWTC
OrthoDBiEOG091G0F0P
PhylomeDBiA5D6W6

Family and domain databases

InterProiView protein in InterPro
IPR019388 FIT
PANTHERiPTHR23129 PTHR23129, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A5D6W6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERGPVVGAG LGAGARIQAL LGCLLKVLLW VASALLYFGS EQAARLLGSP
60 70 80 90 100
CLRRLYHAWL AAVVIFGPLL QFHVNPRTIF ASHGNFFNIK FVNSAWGWTC
110 120 130 140 150
TFLGGFVLLV VFLATRRVAV TARHLSRLVV GAAVWRGAGR AFLLIEDLTG
160 170 180 190 200
SCFEPLPQGL LLHELPDRRS CLAAGHQWRG YTVSSHTFLL TFCCLLMAEE
210 220 230 240 250
AAVFAKYLAH GLPAGAPLRL VFLLNVLLLG LWNFLLLCTV IYFHQYTHKV
260 270 280 290
VGAAVGTFAW YLTYGSWYHQ PWSPGSPGHG LFPRPHSSRK HN
Length:292
Mass (Da):32,207
Last modified:June 12, 2007 - v1
Checksum:i5722083EB85EEDC8
GO
Isoform 2 (identifier: A5D6W6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Note: No experimental confirmation available.
Show »
Length:96
Mass (Da):10,778
Checksum:iF8250E362DE96701
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0314931 – 196Missing in isoform 2. 1 PublicationAdd BLAST196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471078 Genomic DNA Translation: EAW66107.1
BC042179 mRNA No translation available.
BC139911 mRNA Translation: AAI39912.1
CCDSiCCDS9611.1 [A5D6W6-1]
RefSeqiNP_981947.1, NM_203402.2 [A5D6W6-1]
UniGeneiHs.128060

Genome annotation databases

EnsembliENST00000267426; ENSP00000267426; ENSG00000139914 [A5D6W6-1]
ENST00000559294; ENSP00000453741; ENSG00000139914 [A5D6W6-2]
ENST00000642380; ENSP00000493481; ENSG00000285321 [A5D6W6-2]
ENST00000644407; ENSP00000493961; ENSG00000285321 [A5D6W6-1]
GeneIDi161247
KEGGihsa:161247
UCSCiuc001wmf.3 human [A5D6W6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471078 Genomic DNA Translation: EAW66107.1
BC042179 mRNA No translation available.
BC139911 mRNA Translation: AAI39912.1
CCDSiCCDS9611.1 [A5D6W6-1]
RefSeqiNP_981947.1, NM_203402.2 [A5D6W6-1]
UniGeneiHs.128060

3D structure databases

ProteinModelPortaliA5D6W6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127777, 1 interactor

PTM databases

iPTMnetiA5D6W6
PhosphoSitePlusiA5D6W6

Polymorphism and mutation databases

BioMutaiFITM1

Proteomic databases

PaxDbiA5D6W6
PRIDEiA5D6W6
ProteomicsDBi707
708 [A5D6W6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267426; ENSP00000267426; ENSG00000139914 [A5D6W6-1]
ENST00000559294; ENSP00000453741; ENSG00000139914 [A5D6W6-2]
ENST00000642380; ENSP00000493481; ENSG00000285321 [A5D6W6-2]
ENST00000644407; ENSP00000493961; ENSG00000285321 [A5D6W6-1]
GeneIDi161247
KEGGihsa:161247
UCSCiuc001wmf.3 human [A5D6W6-1]

Organism-specific databases

CTDi161247
DisGeNETi161247
EuPathDBiHostDB:ENSG00000139914.6
GeneCardsiFITM1
HGNCiHGNC:33714 FITM1
HPAiHPA019842
MIMi612028 gene
neXtProtiNX_A5D6W6
OpenTargetsiENSG00000139914
PharmGKBiPA165478932
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3750 Eukaryota
ENOG4111CNJ LUCA
GeneTreeiENSGT00530000063693
HOGENOMiHOG000112594
InParanoidiA5D6W6
OMAiSGWGWTC
OrthoDBiEOG091G0F0P
PhylomeDBiA5D6W6

Enzyme and pathway databases

ReactomeiR-HSA-8964572 Lipid particle organization

Miscellaneous databases

GenomeRNAii161247
PROiPR:A5D6W6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139914 Expressed in 85 organ(s), highest expression level in muscle of leg
GenevisibleiA5D6W6 HS

Family and domain databases

InterProiView protein in InterPro
IPR019388 FIT
PANTHERiPTHR23129 PTHR23129, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFITM1_HUMAN
AccessioniPrimary (citable) accession number: A5D6W6
Secondary accession number(s): Q8IUQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: November 7, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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