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Entry version 98 (13 Feb 2019)
Sequence version 1 (12 Jun 2007)
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Protein
Submitted name:

SIN3 transcription regulator family member Aa

Gene

sin3aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription corepressor activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-3899300 SUMOylation of transcription cofactors
R-DRE-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-DRE-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DRE-9022692 Regulation of MECP2 expression and activity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SIN3 transcription regulator family member AaImported
Submitted name:
Zgc:162128 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sin3aaImported
ORF Names:zgc:162128Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070620-3 sin3aa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000079716 Expressed in 26 organ(s), highest expression level in retina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A5D6S0 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000077974

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A5D6S0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini553 – 653HDAC_interactInterPro annotationAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili910 – 930Sequence analysisAdd BLAST21
Coiled coili1140 – 1160Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4204 Eukaryota
COG5602 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155491

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230688

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG060425

KEGG Orthology (KO)

More...
KOi
K11644

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKPCSGR

Database of Orthologous Groups

More...
OrthoDBi
253485at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106187

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
IPR037969 SIN3A

The PANTHER Classification System

More...
PANTHERi
PTHR12346 PTHR12346, 1 hit
PTHR12346:SF2 PTHR12346:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00761 HDAC_interact, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47762 SSF47762, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51477 PAH, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A5D6S0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRRLEDQEP VFTPQQRRLP GSTEGFQHRV LAPAPAVFEA VADSMQPTPG
60 70 80 90 100
IQYPLPQAYQ VSTVAQSSSG HSHTPSPAVH SGPHHHGPAA AQAHAPPPVQ
110 120 130 140 150
GHAHPPTPSA STQGQQQFQR LKVEDALSYL DQVKLQFGNQ PQVYNDFLDI
160 170 180 190 200
MKEFKSQSID TPGVISRVSQ LFKGHPDLIM GFNTFLPPGY KIEVQTNDLV
210 220 230 240 250
NVTTPGQIHH ITPHGISVQN IPIVPPPPPS QQQNQITTNP PNLATTPPAQ
260 270 280 290 300
PAPKTKPLQS PVLTPSSQPN PSIPPYASPR SPPLQPNTPV SSMPIAPPLQ
310 320 330 340 350
NNQPVEFNHA INYVNKIKNR FQGQPNIYKS FLEILHKYQK EQRNAKEAGG
360 370 380 390 400
SYTPVLTEQE VYAEVAQLFK NQEDLLSEFG QFLPDANSTM LLGKTTAEKA
410 420 430 440 450
ESVRNDHGGT VKKPQLNNKQ RPNQNGCQIR KHSTTAITPP VKKKLKLMNI
460 470 480 490 500
KDSSGAEAGK HGGGTESLFF EKVRKVLRSA EAYDNFLRCL VIFNEEIISR
510 520 530 540 550
AELVQLVVPF LGKFPELFTW FKNFLGYKEM SHLETYPKER ATEGIAMEID
560 570 580 590 600
YASCKRLGSS YRALPKSYQL PKCTGRTAIC KEVLNDTWVS FPSWSEDSTF
610 620 630 640 650
VSSKKTQYEE HMYRCEDERF ELDVVLETNL ATIRVLETTQ KKLSRMSAEE
660 670 680 690 700
QAKFRLDNTL GGFSEIIHRK AIQRIYGDKA PDIIDGLKKN PAASVPIVLK
710 720 730 740 750
RLKLKEEEWR EAQRGFNKIW REQNEKYYLK SLDHQGINFK QNDTKVLRSK
760 770 780 790 800
TLLNEIESIF DERQEQVSED NSSTTASSPH LTLTYEDHQI LEDAAALIIH
810 820 830 840 850
HVKRQSSINK EDKYKIKQIV YHFIPDMLFA QRGVLSDVEE EDEEEDMELD
860 870 880 890 900
EGASKKHNGL AGGASASPTK SKLLFSASTA QRLRSCEDAY NLFYVNNNWY
910 920 930 940 950
IFLRLHQILC SRLLRLYAQA ERQIEEDMRE REWEREVLGL KRDKNENTAV
960 970 980 990 1000
QLRLKEPMDV EVEDYYSAFL EMVRNLLDGN MEASQYEDSL REMFTIHAYI
1010 1020 1030 1040 1050
AFTMDKLIQN IARQLQHIVS EEICVQVTEL YLVESGHSST GGSLLTQSSR
1060 1070 1080 1090 1100
AQAEASYQRK AEQLMSDENC FKLMFLKSRG NVQLTVELLD TEEENSDGPM
1110 1120 1130 1140 1150
EIERWSDYVM RYLSADFTSP DLKDHLSQKP VFLPRNLRRI RKCQRGCEAQ
1160 1170 1180 1190 1200
EKELKDGERK ENADSMKMEC MFKLNSYKMV YVFKSEDYMY RRTALLRAHQ
1210 1220 1230 1240 1250
SHERVSTRLH QRFHAWSQRW AKEHVTRDMA AETSRWLMGE GREGLLPCST
1260 1270
SCDPEILHFQ RINKYRVKYG PTNKPQ
Length:1,276
Mass (Da):145,784
Last modified:June 12, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i262276CBC9980301
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QGR1E9QGR1_DANRE
SIN3 transcription regulator family...
sin3aa
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU207224 Genomic DNA No translation available.
BC139856 mRNA Translation: AAI39857.1

NCBI Reference Sequences

More...
RefSeqi
NP_001091650.1, NM_001098180.1
XP_005163027.1, XM_005162970.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.79679

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000083539; ENSDARP00000077974; ENSDARG00000079716

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
563090

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:563090

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207224 Genomic DNA No translation available.
BC139856 mRNA Translation: AAI39857.1
RefSeqiNP_001091650.1, NM_001098180.1
XP_005163027.1, XM_005162970.3
UniGeneiDr.79679

3D structure databases

SMRiA5D6S0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077974

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000083539; ENSDARP00000077974; ENSDARG00000079716
GeneIDi563090
KEGGidre:563090

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
563090
ZFINiZDB-GENE-070620-3 sin3aa

Phylogenomic databases

eggNOGiKOG4204 Eukaryota
COG5602 LUCA
GeneTreeiENSGT00940000155491
HOGENOMiHOG000230688
HOVERGENiHBG060425
KOiK11644
OMAiQKPCSGR
OrthoDBi253485at2759
TreeFamiTF106187

Enzyme and pathway databases

ReactomeiR-DRE-3899300 SUMOylation of transcription cofactors
R-DRE-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-DRE-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DRE-9022692 Regulation of MECP2 expression and activity

Gene expression databases

BgeeiENSDARG00000079716 Expressed in 26 organ(s), highest expression level in retina
ExpressionAtlasiA5D6S0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
IPR037969 SIN3A
PANTHERiPTHR12346 PTHR12346, 1 hit
PTHR12346:SF2 PTHR12346:SF2, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761 HDAC_interact, 1 hit
SUPFAMiSSF47762 SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477 PAH, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5D6S0_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5D6S0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: February 13, 2019
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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