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Entry version 87 (02 Dec 2020)
Sequence version 1 (12 Jun 2007)
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Protein
Submitted name:

Hcfc1a protein

Gene

hcfc1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Hcfc1a proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hcfc1aImported
Synonyms:hcfc1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030912-10, hcfc1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A5D6R2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini365 – 459Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1552 – 1654Fibronectin type-IIIInterPro annotationAdd BLAST103
Domaini1656 – 1771Fibronectin type-IIIInterPro annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni414 – 458DisorderedSequence analysisAdd BLAST45
Regioni937 – 971DisorderedSequence analysisAdd BLAST35
Regioni1044 – 1068DisorderedSequence analysisAdd BLAST25
Regioni1116 – 1176DisorderedSequence analysisAdd BLAST61
Regioni1181 – 1200DisorderedSequence analysisAdd BLAST20
Regioni1206 – 1282DisorderedSequence analysisAdd BLAST77
Regioni1767 – 1800DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1452 – 1482Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi437 – 458PolarSequence analysisAdd BLAST22
Compositional biasi947 – 971PolarSequence analysisAdd BLAST25
Compositional biasi1116 – 1173PolarSequence analysisAdd BLAST58
Compositional biasi1184 – 1200PolarSequence analysisAdd BLAST17
Compositional biasi1206 – 1264PolarSequence analysisAdd BLAST59

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, Kelch repeatARBA annotation, RepeatARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR037854, HCF1
IPR043536, HCF1/2
IPR013783, Ig-like_fold
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1

The PANTHER Classification System

More...
PANTHERi
PTHR46003, PTHR46003, 5 hits
PTHR46003:SF3, PTHR46003:SF3, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01344, Kelch_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281, SSF117281, 2 hits
SSF49265, SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5D6R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSPGVPGTT GAPLQPRWKR VLGWSGPVPR PRHGHRAVAI KELMVVFGGG
60 70 80 90 100
NEGIVDELHV YNTATNQWFI PAVRGDIPPG CAAYGFVCDG TRLLVFGGMV
110 120 130 140 150
EYGKYSNDLY ELQASRWEWK KLKPKAPKNG VPPCPRLGHS FSLVGNKCYL
160 170 180 190 200
FGGLANDSED PKNNIPRYLN DLYTLELRPG SSVAGWDVPV TYGVLPPPRE
210 220 230 240 250
SHTAVIYTEK VTKKSRLVIY GGMSGCRLGD LWTLDIDTLT WNKPAISGAA
260 270 280 290 300
PLPRSLHSAT TITNKMYVFG GWVPLVMDDV KVATHEKEWK CTNTLACLNL
310 320 330 340 350
DTLAWETVLM DTLEDNIPRA RAGHCAVAIN NRLYIWSGRD GYRKAWNNQV
360 370 380 390 400
CCKDLWYLET ERPNPPSRVQ LVRANTNSLE VSWGAVSTAD TYLLQLQKYD
410 420 430 440 450
IPAATAATSP ALNAAPSLPG NSPKSPAPAA AAPSAQSLPH SGITSVPQAA
460 470 480 490 500
SPTASVLPGT PASPLAASMA RGPAILKVAA PQSGTGASIV TVRQASQVGK
510 520 530 540 550
SPVTVASLPA GVRMVVPSQT AQGTPIGSSP QMSGMAALAA AAAATQKIPP
560 570 580 590 600
SPGATVLNMP AGATIVKTVA VTPGASTLPT TVKVASPLMV SNPATRMLKT
610 620 630 640 650
AAAQVATPTV SSPTTGARPI ITVHKSGTVT VAQQAQVVTT VVGGVTKTIT
660 670 680 690 700
LVKSPLSMGG NLISNLGKVV SVVQNKPVQS ATVTGQASNP LTQIIQTKGP
710 720 730 740 750
LPPGTILKLV TSADGKPTTI ITTSQAGGTG NKPTILGISG MSPTSTSKPG
760 770 780 790 800
TTTIIKTIPM SAVQQGAAGV TSTTGVKSPI TIITTKVMTS GTPGKIITAM
810 820 830 840 850
PKIGTAAGQQ GLTQVVLKGA PGQPGTILRT VPMGGVRLVS PVSGVKPTVT
860 870 880 890 900
TLVVKGTTGV TTLGTVTGTV SSSLAGGSLA SANATLATPI TTLGTIATLA
910 920 930 940 950
SQVINATNVT AAQSNLTTVT STMQPTQVTL ITTPSGVEAQ PGQDLPVSFL
960 970 980 990 1000
ASPTSEQPTS TESGTGEASG SVTLVCSNPP CETHETGTTN TATTATSNMG
1010 1020 1030 1040 1050
AGPAGTVQRV CSNPPCETHE TGTTNTATTA SANMGAVQRV CSNPPCETHE
1060 1070 1080 1090 1100
TGTTSTTTTA SSNMGTAPAG TVQRVCSNPP CETHETGTTN TATTASSNMG
1110 1120 1130 1140 1150
GNQPGAVQRV CSNPPCETHE TGTTNTATTA SSSMGGGQEG TVQRVCSNPP
1160 1170 1180 1190 1200
CETHETGTTN TATTSSSNMG GDQAGAVQRV CSNPPCETHE TGTTNTATTA
1210 1220 1230 1240 1250
TCNMETDEGT AQQTSEASES STSTESLPAT AAAQRGAITT VTQATPLPGP
1260 1270 1280 1290 1300
AVPSISSITE SSSEAGAEPV VMESSEAESL QTEGQAEAEA VAMQAEFQTE
1310 1320 1330 1340 1350
AGAVALPTDF QEDAAALPAD FQGEAVAVAM QAESQADAVP MEQDVSGMAE
1360 1370 1380 1390 1400
GEATQEQLPT AEMEDVDAAS ASQAAVLALP PELMADGQST TLMVTGLTPE
1410 1420 1430 1440 1450
ELAVTAAAEA AAQAAATEEA QALAIQAVLQ AAQQAVMSDA GGDDQQTHTI
1460 1470 1480 1490 1500
PIVLTQQELA ALVQQQQQLQ AAQQQAAAQA ALPTEGLAPA DSLNDPLSES
1510 1520 1530 1540 1550
NGHNEMAAAA TSAVVTLLPR TAAETLAPSS TLAPVVVASP AKMQAAAALT
1560 1570 1580 1590 1600
EVANGIEAGK QNPPTVTVKP QVKKENQWFD VGIVKVTNTV VTHFYMPADD
1610 1620 1630 1640 1650
SAYVENDSGT APDYSQMKRV ELQPGTAYKF RVAGINTCGR GTFSEISAFK
1660 1670 1680 1690 1700
TCLPGFPGAP CAIKISKSPD GAHLTWEPPS VTSGKITEYS VYLAIQSSQT
1710 1720 1730 1740 1750
TEAKPSAPAQ LAFMRVYCGP NPSCLVQSSS LSNAHIDYTT KPAIIFRIAA
1760 1770 1780 1790 1800
RNEKGYGPAT QVRWLQESSK DGLSAKPAPK RAVSSPDTKG IGQKKARMDQ
Length:1,800
Mass (Da):184,718
Last modified:June 12, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AE30E522222A668
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC139848 mRNA Translation: AAI39849.1
BC142544 mRNA Translation: AAI42545.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139848 mRNA Translation: AAI39849.1
BC142544 mRNA Translation: AAI42545.1

3D structure databases

SMRiA5D6R2
ModBaseiSearch...

Organism-specific databases

ZFINiZDB-GENE-030912-10, hcfc1a

Family and domain databases

CDDicd00063, FN3, 2 hits
Gene3Di2.120.10.80, 2 hits
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR037854, HCF1
IPR043536, HCF1/2
IPR013783, Ig-like_fold
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
PANTHERiPTHR46003, PTHR46003, 5 hits
PTHR46003:SF3, PTHR46003:SF3, 5 hits
PfamiView protein in Pfam
PF01344, Kelch_1, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SUPFAMiSSF117281, SSF117281, 2 hits
SSF49265, SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5D6R2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5D6R2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 2, 2020
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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