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Entry version 80 (02 Dec 2020)
Sequence version 1 (12 Jun 2007)
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Protein
Submitted name:

Clasp1 protein

Gene

Clasp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Clasp1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Clasp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923957, Clasp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CentromereARBA annotation, ChromosomeARBA annotation, CytoplasmARBA annotation, KinetochoreARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A5D6Q8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A5D6Q8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A5D6Q8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 232TOGInterPro annotationAdd BLAST232
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati168 – 206HEATPROSITE-ProRule annotationAdd BLAST39
Domaini319 – 551TOGInterPro annotationAdd BLAST233
Domaini810 – 1048TOGInterPro annotationAdd BLAST239
Domaini1211 – 1449TOGInterPro annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni237 – 290DisorderedSequence analysisAdd BLAST54
Regioni543 – 738DisorderedSequence analysisAdd BLAST196
Regioni780 – 802DisorderedSequence analysisAdd BLAST23
Regioni1042 – 1085DisorderedSequence analysisAdd BLAST44
Regioni1125 – 1191DisorderedSequence analysisAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1230 – 1250Sequence analysisAdd BLAST21
Coiled coili1312 – 1332Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi250 – 288PolarSequence analysisAdd BLAST39
Compositional biasi543 – 624PolarSequence analysisAdd BLAST82
Compositional biasi639 – 683PolarSequence analysisAdd BLAST45
Compositional biasi696 – 720PolarSequence analysisAdd BLAST25
Compositional biasi787 – 801PolarSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
66632at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR028399, CLASP_1
IPR024395, CLASP_N_dom
IPR021133, HEAT_type_2
IPR034085, TOG

The PANTHER Classification System

More...
PANTHERi
PTHR21567:SF28, PTHR21567:SF28, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12348, CLASP_N, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349, TOG, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077, HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5D6Q8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPRMESCLA QVLQKDVGKR LQVGQELIDY FSDRQKSADL EHDQTLLDKL
60 70 80 90 100
VDGLATSWVN SSNYKVVLLG MDILSALVTR LQDRFKAQIG TVLPSLIDRL
110 120 130 140 150
GDAKDSVREQ DQTLLLKIMD QAANPQYVWD RMLGGFKHKN FRTREGICLC
160 170 180 190 200
LIATLNASGA QTLTLSKIVP HICNLLGDPN SQVRDAAINS LVEIYRHVGE
210 220 230 240 250
RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANEKN FDDEDSVDGN
260 270 280 290 300
RPSSASSSSS KAPSSSRRNV NLGTTRRLMS SSLGSKSSAA KEGAGAVDEE
310 320 330 340 350
DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVNALKKIRS
360 370 380 390 400
LLLAGAAEYD NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG
410 420 430 440 450
NKFDHGAEAI MPTIFNLIPN SAKIMATSGV VAVRLIIRHT HIPRLIPVIT
460 470 480 490 500
SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL ERHISVLAET IKKGIHDADS
510 520 530 540 550
EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL KNSDSIVSLP
560 570 580 590 600
QSDRSSSSSQ ESLNRPLSAK RSPTGSTASR GSTVSTKSVS TTGSLQRSRS
610 620 630 640 650
EIDVNAAASA KSKVSSSSGS PAFSSAAALP PGSYASLGRI RTRRQSSGST
660 670 680 690 700
TNVASTPSDS RGRSRAKVVS QSQPGSRSSS PGKLLGSGLA GGSSRGPPVT
710 720 730 740 750
PSSEKRSKIP RSQGCSRETS PNRIGLDRFG LGQSGRIPGS VNAMRVLSTS
760 770 780 790 800
TDLEAAVADA LLLGDARSKK KPVRRRYEPY GMYSDDDANS DASSVRSERS
810 820 830 840 850
YGSRNGGIPH YLRQTEDVAE VLNHCASSNW SERKEGLLGL QNLLKSQRTL
860 870 880 890 900
SRVELKRLCE IFTRMFADPH SKRVFSMFLE TLVDFIIIHK DDLQDWLFVL
910 920 930 940 950
LTQLLKKMGA DLLGSVQAKV QKALDVTRDS FPFDQQFNIL MRFIVDQTQT
960 970 980 990 1000
PNLKVKVAIL KYIESLARQM DPTDFVNSSE TRLAVSRIIT WTTEPKSSDV
1010 1020 1030 1040 1050
RKAAQIVLIS LFELNTPEFT MLLGALPKTF QDGATKLLHN HLKNSSNTGV
1060 1070 1080 1090 1100
GSPSNTIGRT PSRHPSSRTS PLTSPTNCSH GGLSPSMLDY DTENLNSEEI
1110 1120 1130 1140 1150
YSSLRGVTEA IEKFSFRSQE DLNEPIKRDG KKDCDIVSRD GGAASPATEG
1160 1170 1180 1190 1200
RGGSEIEGGR MALDNKTSLL NTQPPRAFPG PRAREYNPYP YSDTINTYDK
1210 1220 1230 1240 1250
TALKEAVFDD DMEQLRDVPI DHSDLVADLL KELSNHNERV EERKGALLEL
1260 1270 1280 1290 1300
LKITREDSLG VWEEHFKTIL LLLLETLGDK DHSIRALALR VLREILRNQP
1310 1320 1330 1340 1350
ARFKNYAELT IMKTLEAHKD SHKEVVRAAE EAASTLASSI HPEQCIKVLC
1360 1370 1380 1390 1400
PIIQTADYPI NLAAIKMQTK VVERITKESL LQLLVDIIPG LLQGYDNTES
1410 1420 1430 1440 1450
SVRKASVFCL VAIYSVIGED LKPHLAQLTG SKMKLLNLYI KRAQTTNSNS
1460
SSSSDVSTHS
Length:1,460
Mass (Da):161,144
Last modified:June 12, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12B3D717DBB80A5B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC094432 mRNA Translation: AAH94432.1

NCBI Reference Sequences

More...
RefSeqi
NP_001280229.1, NM_001293300.1
NP_001280230.1, NM_001293301.1
NP_083985.2, NM_029709.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
76707

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:76707

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094432 mRNA Translation: AAH94432.1
RefSeqiNP_001280229.1, NM_001293300.1
NP_001280230.1, NM_001293301.1
NP_083985.2, NM_029709.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiA5D6Q8

Proteomic databases

PeptideAtlasiA5D6Q8

Genome annotation databases

GeneIDi76707
KEGGimmu:76707

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23332
MGIiMGI:1923957, Clasp1

Phylogenomic databases

OrthoDBi66632at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
76707, 0 hits in 8 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Clasp1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiA5D6Q8, MM

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR028399, CLASP_1
IPR024395, CLASP_N_dom
IPR021133, HEAT_type_2
IPR034085, TOG
PANTHERiPTHR21567:SF28, PTHR21567:SF28, 3 hits
PfamiView protein in Pfam
PF12348, CLASP_N, 2 hits
SMARTiView protein in SMART
SM01349, TOG, 4 hits
SUPFAMiSSF48371, SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077, HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5D6Q8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5D6Q8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 2, 2020
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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