Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - A5CVE4 (A5CVE4_MOUSE)

Entry version 109 (25 May 2022)
Sequence version 1 (12 Jun 2007)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Stromal interaction molecule 2

Gene

Stim2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCalcium transportARBA annotation, Ion transport, Transport
LigandCalcium, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Stromal interaction molecule 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Stim2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2151156, Stim2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000039156

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A5CVE4

PeptideAtlas

More...PeptideAtlasi		A5CVE4

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		A5CVE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000039156, Expressed in vestibular membrane of cochlear duct and 263 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A5CVE4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini136 – 194SAMInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni490 – 562DisorderedSequence analysisAdd BLAST73
Regioni592 – 651DisorderedSequence analysisAdd BLAST60
Regioni684 – 746DisorderedSequence analysisAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili252 – 289Sequence analysisAdd BLAST38
Coiled coili318 – 338Sequence analysisAdd BLAST21
Coiled coili370 – 390Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi504 – 530Polar residuesSequence analysisAdd BLAST27
Compositional biasi594 – 625Polar residuesSequence analysisAdd BLAST32
Compositional biasi684 – 720Polar residuesSequence analysisAdd BLAST37

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010588_2_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		ISDPCMS

Database of Orthologous Groups

More...OrthoDBi		373308at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A5CVE4

Family and domain databases

Conserved Domains Database

More...CDDi		cd09574, SAM_STIM2, 1 hit
cd11722, SOAR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR032393, SOAR
IPR037608, STIM
IPR037610, STIM2_SAM

The PANTHER Classification System

More...PANTHERi		PTHR15136, PTHR15136, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07647, SAM_2, 1 hit
PF16533, SOAR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A5CVE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLFGLLVAG VADGCDLVPR HLRGRRASGS AGAAASPSAA AAGERQALLT 
        60         70         80         90        100
DPCMSLSPPC FTEEDRFSLE ALQTIHKQMD DDKDGGIEVD ESDEFIREDM 
       110        120        130        140        150
KYKDATNKHS HLHREDKHIT VEDLWKQWKT SEVHNWTLED TLQWLIEFVE 
       160        170        180        190        200
LPQYEKNFRD NNVKGTTLPR IAVHETSFMI SQLKISDRSH RQKLQLKALD 
       210        220        230        240        250
VVLFGPLTRP PHNWMKDFIL TISIVIGVGG CWFAYTQNKT SKEHVAKMMK 
       260        270        280        290        300
DLESLQTAEQ SLMDLQERLE KAQEENRTVA VEKQNLERKM MDEINYAKEE 
       310        320        330        340        350
ACRLRELREG AECELSRRQY AEQELEQVRM ALKKAEKEFE LRSSWSVPDA 
       360        370        380        390        400
LQKWLQLTHE VEVQYYNIKR QNAEMQLAIA KDEAEKIKKK RSTVFGTLHV 
       410        420        430        440        450
AHSSSLDEVD HKILEAKKAL SELTTCLRER LFRWQQIEKI CGFQIAHNSG 
       460        470        480        490        500
LPSLTSSLYS DHSWVVMPRV SIPPYPIAGG VDDLDEDTPP IVPQFPGTVA 
       510        520        530        540        550
KPAGSLARSS SLCRSRRSIV PSSPQSQRAQ LPAHAPLAAH PRHPHHPQHP 
       560        570        580        590        600
QHSLPSPDPD ILSVSSCPAL YRNEEEEEAI YFTAEKQWEV PDTASECDSL 
       610        620        630        640        650
NSSSGRKPSP PSSLEMYQTL SSRKISRDEL SLEDSSRGES PVTADVSRGS 
       660        670        680        690        700
PECVGLTETK SMIFSPASRV YNGILEKSCS MHQLSSGIPV PHPRHTSCSS 
       710        720        730        740 
AGNDSKPVQE ASNVSRVSSI PHDLCHNGEK SKKPSKIKSL FKKKSK
Length:746
Mass (Da):83,925
Last modified:June 12, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE48455117B4E0BD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AM712359 mRNA Translation: CAN36430.1

NCBI Reference Sequences

More...RefSeqi		NP_001074572.2, NM_001081103.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116873

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:116873

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM712359 mRNA Translation: CAN36430.1
RefSeqiNP_001074572.2, NM_001081103.2

3D structure databases

SMRiA5CVE4
ModBaseiSearch...

PTM databases

SwissPalmiA5CVE4

Proteomic databases

EPDiA5CVE4
PeptideAtlasiA5CVE4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10303, 273 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		116873

Genome annotation databases

GeneIDi116873
KEGGimmu:116873

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57620
MGIiMGI:2151156, Stim2
VEuPathDBiHostDB:ENSMUSG00000039156

Phylogenomic databases

HOGENOMiCLU_010588_2_0_1
OMAiISDPCMS
OrthoDBi373308at2759
PhylomeDBiA5CVE4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		116873, 3 hits in 71 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Stim2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000039156, Expressed in vestibular membrane of cochlear duct and 263 other tissues

Family and domain databases

CDDicd09574, SAM_STIM2, 1 hit
cd11722, SOAR, 1 hit
Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR032393, SOAR
IPR037608, STIM
IPR037610, STIM2_SAM
PANTHERiPTHR15136, PTHR15136, 1 hit
PfamiView protein in Pfam
PF07647, SAM_2, 1 hit
PF16533, SOAR, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5CVE4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5CVE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 25, 2022
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again