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Protein

Keratin, type II cytoskeletal 5

Gene

KRT5

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei421Stutter1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name:
CK-5
Keratin-5
Short name:
K5
Type-II keratin Kb5
Gene namesi
Name:KRT5
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003568261 – 592Keratin, type II cytoskeletal 5Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei26PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei64PhosphoserineBy similarity1
Modified residuei71PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei82PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA5A6M8

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network. Heterodimer with KRT14. Interacts with TCHP. Interacts with EPPK1.By similarity

Structurei

3D structure databases

ProteinModelPortaliA5A6M8
SMRiA5A6M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 483IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 169HeadAdd BLAST169
Regioni170 – 205Coil 1AAdd BLAST36
Regioni206 – 224Linker 1Add BLAST19
Regioni225 – 317Coil 1BAdd BLAST93
Regioni318 – 340Linker 12Add BLAST23
Regioni341 – 479Coil 2Add BLAST139
Regioni480 – 592TailAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 141Gly-richAdd BLAST103
Compositional biasi530 – 592Ser-richAdd BLAST63

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiA5A6M8
KOiK07605

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5A6M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSSVSFR SGGSRSFSTA SAITPSVSRT SFTSVSRSGG GGGGGFGRVS
60 70 80 90 100
LGGACGVGGY GSRSLYNLGG SKWISISTSG GSFRNRFGAG AGAGGGYGFG
110 120 130 140 150
GGAGSGFGFG GGAGGGFGLG GGAGFGGGYG GPGFPVCPPG GIQEVTVNQS
160 170 180 190 200
LLTPLNLQID PSIQRVRTEE REQIKTLNNK FASFIDKVRF LEQQNKVLDT
210 220 230 240 250
KWTLLQEQGT KTVRQNLEPL FEQYINNLRR QLDSIVGERG RLDSELRNMQ
260 270 280 290 300
DLVEDFKNKY EDEINKRTTA ENEFVMLKKD VDAAYMNKVE LEAKVDALMD
310 320 330 340 350
EINFMKMFFD AELSQMQTHV SDTSVVLSMD NNRNLDLDSI IAEVKAQYEE
360 370 380 390 400
IANRSRTEAE SWYQTKYEEL QQTAGRHGDD LRNTKHEISE MNRMIQRLRA
410 420 430 440 450
EIDNVKKQCA NLQNAIADAE QRGELALKDA RNKLAELEEA LQKAKQDMAR
460 470 480 490 500
LLREYQELMN TKLALDVEIA TYRKLLEGEE CRLSGEGVGP VNISVVTSSV
510 520 530 540 550
SSGYGSGSGY GGGLGGGLGG GLGGSLAGGG SGSYYSSSSG GVGLGGGLSV
560 570 580 590
GGSGFSASSG RGLGVGFGSG GGSSSSVKFV STTSSSRKSF KS
Length:592
Mass (Da):62,538
Last modified:June 12, 2007 - v1
Checksum:i4EC68886890D89BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB222156 mRNA Translation: BAF62401.1
RefSeqiNP_001266996.1, NM_001280067.1
UniGeneiPtr.2691

Genome annotation databases

GeneIDi100615215
KEGGiptr:100615215

Similar proteinsi

Entry informationi

Entry nameiK2C5_PANTR
AccessioniPrimary (citable) accession number: A5A6M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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