UniProtKB - A5A6H4 (ROA1_PANTR)
Protein
Heterogeneous nuclear ribonucleoprotein A1
Gene
HNRNPA1
Organism
Pan troglodytes (Chimpanzee)
Status
Functioni
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1.By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- cellular response to sodium arsenite Source: UniProtKB
- mRNA processing Source: UniProtKB-KW
- mRNA transport Source: UniProtKB-KW
- RNA splicing Source: UniProtKB-KW
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing, mRNA transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Heterogeneous nuclear ribonucleoprotein A1Short name: hnRNP A1 Alternative name(s): Helix-destabilizing protein Single-strand-binding protein hnRNP core protein A1 Cleaved into the following chain: |
Gene namesi | Name:HNRNPA1 Synonyms:HNRPA1 |
Organismi | Pan troglodytes (Chimpanzee) |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
- spliceosomal complex Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-SubCell
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000424512 | 1 – 320 | Heterogeneous nuclear ribonucleoprotein A1Add BLAST | 320 | |
Initiator methioninei | Removed; alternateBy similarity | |||
ChainiPRO_0000295287 | 2 – 320 | Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedAdd BLAST | 319 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedBy similarity | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 3 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 3 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 4 | PhosphoserineBy similarity | 1 | |
Modified residuei | 6 | PhosphoserineBy similarity | 1 | |
Cross-linki | 8 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 22 | PhosphoserineBy similarity | 1 | |
Cross-linki | 78 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 113 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Cross-linki | 179 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 183 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 192 | Phosphoserine; by MKNK2By similarity | 1 | |
Modified residuei | 194 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 194 | Dimethylated arginine; alternateBy similarity | 1 | |
Modified residuei | 194 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 199 | PhosphoserineBy similarity | 1 | |
Modified residuei | 206 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 206 | Dimethylated arginine; alternateBy similarity | 1 | |
Modified residuei | 206 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 218 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 218 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 225 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 225 | Dimethylated arginine; alternateBy similarity | 1 | |
Modified residuei | 225 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 232 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 232 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 284 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 285 | PhosphoserineBy similarity | 1 | |
Modified residuei | 298 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 298 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 300 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 309 | PhosphoserineBy similarity | 1 | |
Modified residuei | 310 | Phosphoserine; by MKNK2By similarity | 1 | |
Modified residuei | 311 | Phosphoserine; by MKNK2By similarity | 1 | |
Modified residuei | 312 | Phosphoserine; by MKNK2By similarity | 1 | |
Modified residuei | 313 | PhosphoserineBy similarity | 1 | |
Modified residuei | 316 | PhosphoserineBy similarity | 1 | |
Modified residuei | 318 | Omega-N-methylarginineBy similarity | 1 |
Post-translational modificationi
Sumoylated.By similarity
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | A5A6H4 |
PRIDEi | A5A6H4 |
Expressioni
Gene expression databases
Bgeei | ENSPTRG00000028756, Expressed in cerebellum and 7 other tissues |
Interactioni
Subunit structurei
Identified in the spliceosome C complex.
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.
Interacts with SEPT6.
Interacts with C9orf72.
Interacts with KHDRBS1.
Interacts with UBQLN2 (By similarity).
Interacts with PPIA/CYPA (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9598.ENSPTRP00000048316 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 97 | RRM 1PROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 105 – 184 | RRM 2PROSITE-ProRule annotationAdd BLAST | 80 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 4 – 94 | Globular A domainAdd BLAST | 91 | |
Regioni | 95 – 185 | Globular B domainAdd BLAST | 91 | |
Regioni | 218 – 240 | RNA-binding RGG-boxAdd BLAST | 23 | |
Regioni | 268 – 305 | Nuclear targeting sequenceBy similarityAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 195 – 320 | Gly-richAdd BLAST | 126 | |
Compositional biasi | 308 – 313 | Poly-Ser | 6 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00950000183123 |
HOGENOMi | CLU_012062_1_0_1 |
InParanoidi | A5A6H4 |
OrthoDBi | 1202220at2759 |
TreeFami | TF351342 |
Family and domain databases
CDDi | cd12761, RRM1_hnRNPA1, 1 hit cd12580, RRM2_hnRNPA1, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR021662, HnRNPA1 IPR034845, hnRNPA1_RRM1 IPR034803, hnRNPA1_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF11627, HnRNPA1, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A5A6H4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN
60 70 80 90 100
TKRSRGFGFV TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA
110 120 130 140 150
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF
160 170 180 190 200
VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA LSKQEMASAS SSQRGRSGSG
210 220 230 240 250
NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS GDGYNGFGND
260 270 280 290 300
GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPR
310 320
NQGGYGGSSS SSSYGSGRRF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3TAT5 | A0A2I3TAT5_PANTR | Helix-destabilizing protein | HNRNPA1 | 372 | Annotation score: | ||
A0A2I3SLE4 | A0A2I3SLE4_PANTR | Helix-destabilizing protein | HNRNPA1 | 267 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB222102 mRNA Translation: BAF62347.1 AL954201 Genomic DNA Translation: CAH18571.1 |
RefSeqi | NP_001091892.1, NM_001098422.2 NP_001184040.1, NM_001197111.1 |
Genome annotation databases
Ensembli | ENSPTRT00000090598; ENSPTRP00000065492; ENSPTRG00000049417 |
GeneIDi | 739306 747284 |
KEGGi | ptr:739306 ptr:747284 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB222102 mRNA Translation: BAF62347.1 AL954201 Genomic DNA Translation: CAH18571.1 |
RefSeqi | NP_001091892.1, NM_001098422.2 NP_001184040.1, NM_001197111.1 |
3D structure databases
BMRBi | A5A6H4 |
SMRi | A5A6H4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000048316 |
Proteomic databases
PaxDbi | A5A6H4 |
PRIDEi | A5A6H4 |
Genome annotation databases
Ensembli | ENSPTRT00000090598; ENSPTRP00000065492; ENSPTRG00000049417 |
GeneIDi | 739306 747284 |
KEGGi | ptr:739306 ptr:747284 |
Organism-specific databases
CTDi | 3178 739306 |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00950000183123 |
HOGENOMi | CLU_012062_1_0_1 |
InParanoidi | A5A6H4 |
OrthoDBi | 1202220at2759 |
TreeFami | TF351342 |
Gene expression databases
Bgeei | ENSPTRG00000028756, Expressed in cerebellum and 7 other tissues |
Family and domain databases
CDDi | cd12761, RRM1_hnRNPA1, 1 hit cd12580, RRM2_hnRNPA1, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR021662, HnRNPA1 IPR034845, hnRNPA1_RRM1 IPR034803, hnRNPA1_RRM2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF11627, HnRNPA1, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ROA1_PANTR | |
Accessioni | A5A6H4Primary (citable) accession number: A5A6H4 Secondary accession number(s): Q564E0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | June 12, 2007 | |
Last modified: | December 2, 2020 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |