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Protein
Submitted name:

FACT complex large subunit

Gene

supt16h

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • histone binding Source: GO_Central
  • nucleosome binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DRE-112382 Formation of RNA Pol II elongation complex
R-DRE-674695 RNA Polymerase II Pre-transcription Events
R-DRE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DRE-6804756 Regulation of TP53 Activity through Phosphorylation
R-DRE-75955 RNA Polymerase II Transcription Elongation

Names & Taxonomyi

Protein namesi
Submitted name:
FACT complex large subunitImported
Submitted name:
SPT16 homolog, facilitates chromatin-remodeling subunitImported
Submitted name:
Suppressor of Ty 16 homologImported
Gene namesi
Name:supt16hImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-031118-96 supt16h

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiA5A4L9

Expressioni

Gene expression databases

BgeeiENSDARG00000079949 Expressed in 28 organ(s), highest expression level in testis

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111043

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 168FACT-Spt16_NlobInterPro annotationAdd BLAST164
Domaini530 – 690SPT16InterPro annotationAdd BLAST161
Domaini807 – 897Rtt106InterPro annotationAdd BLAST91

Phylogenomic databases

eggNOGiKOG1189 Eukaryota
COG5406 LUCA
GeneTreeiENSGT00390000014495
HOGENOMiHOG000209079
HOVERGENiHBG092544
OMAiEPPFMVI
OrthoDBiEOG091G044Q
TreeFamiTF300341

Family and domain databases

CDDicd01091 CDC68-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.350.10, 1 hit
InterProiView protein in InterPro
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR013719 DUF1747
IPR029148 FACT-Spt16_Nlobe
IPR013953 FACT_Spt16p
IPR000994 Pept_M24
IPR011993 PH-like_dom_sf
IPR033825 SPT16
PfamiView protein in Pfam
PF14826 FACT-Spt16_Nlob, 1 hit
PF00557 Peptidase_M24, 1 hit
PF08512 Rtt106, 1 hit
PF08644 SPT16, 1 hit
SMARTiView protein in SMART
SM01285 FACT-Spt16_Nlob, 1 hit
SM01287 Rtt106, 1 hit
SM01286 SPT16, 1 hit
SUPFAMiSSF55920 SSF55920, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A5A4L9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSLDKDAF YRRIKRLYGN WKKGEDEFGK VDAIVVSVGV DEEIVYAKST
60 70 80 90 100
ALQTWLFGYE LTDTIMVFCE SKIIFLASKK KVEFLKQVAV TKGNENANGV
110 120 130 140 150
PPITLLVREK NESNKVNFDK MIEAIRGSKE GKTVGVFIKD KFPGEYMKSW
160 170 180 190 200
SDTITAEGLQ KVDISTVVAY TMAVKEDGEL ALMKKAASIT TDVFSKFFKE
210 220 230 240 250
RVMEIVDADE KVKHSRLAES VEKAIEDRKF LGGVDPSTVE MCYPPIIQSG
260 270 280 290 300
GNYSLKFSVV SDKNHMHFGA ITCAMGIRYK SYCSNLVRTL MVDPSQEMQD
310 320 330 340 350
NYNFLLQVEE ELLKEMKHGV KLSEAYNAVM EFVKKEKPDL VSKLTKNLGF
360 370 380 390 400
AMGIEFREGS LVINQKNQFK LKRGMVFSIS LGFADMINKE GKKEEQKKYA
410 420 430 440 450
LFIGDTIQIN EEDQATVLTP VKKKIKNVGI FLKNDDEDED EEEGDNAEEL
460 470 480 490 500
LGKGARSAAL LADRTRNEMT AEEKRRTHQK ELANQVNEEA KRRLTEQKGG
510 520 530 540 550
QQIQKVRKSN VSYKNVSQMP KEKDIRDMKI FIDKKHETVI MPVFGIATPF
560 570 580 590 600
HIATIKNISM SVEGDYTYLR INFFVPGSSL GRHEGNIFPN PEATFVKEIT
610 620 630 640 650
YRASNLKSPG DHSVPSTNLQ NAFRIIKEVQ KRYKTREAEE KEKEGIVKQD
660 670 680 690 700
SLVINLNRSN PKLKDLYIRP NIAQKRMQGS LEAHTNGFRF TSVRGDKVDI
710 720 730 740 750
LYNNIKHAIF QPCDGEMIIV LHFHLKNAIM FGKKRHTDVQ FYTEVGEITT
760 770 780 790 800
DLGKHQHMHD RDDLYAEQME REMRHKLKSA FKNFIEKVES LTKEELEFEV
810 820 830 840 850
PFRDLGFQGA PYRSTCLLQP TSSSLCNVTE WPPFVVTLDE VELVHFERVQ
860 870 880 890 900
FHLKNFDVVI VYKDYNKKVT MINAVPVNSL DPIKEWLNSC DIKYTEGIQS
910 920 930 940 950
LNWTKIMKTI VDDPEGFFEQ GGWSFLDPES EGSGGEEDSE SEIEDETFNP
960 970 980 990 1000
SADEEEEEEE DSDEDYSSET EDSDYSASLG SEEESGKDWD ELEEEARKAD
1010 1020 1030
RESQYEEVEE TSNRKRKGRS SAPPPRSKKK RRH
Length:1,033
Mass (Da):118,184
Last modified:May 29, 2007 - v1
Checksum:i2F5BC6E88DB308A6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8QKY6A0A2R8QKY6_DANRE
SPT16 homolog, facilitates chromati...
supt16h
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248243 Genomic DNA No translation available.
CABZ01078837 Genomic DNA No translation available.
BC163334 mRNA Translation: AAI63334.1
BC163336 mRNA Translation: AAI63336.1
EF527261 mRNA Translation: ABP88965.1
RefSeqiNP_001091053.1, NM_001097584.2
UniGeneiDr.105269
Dr.118654

Genome annotation databases

EnsembliENSDART00000126840; ENSDARP00000111043; ENSDARG00000079949
ENSDART00000172830; ENSDARP00000142119; ENSDARG00000079949
ENSDART00000177863; ENSDARP00000143354; ENSDARG00000079949
GeneIDi562348
KEGGidre:562348

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248243 Genomic DNA No translation available.
CABZ01078837 Genomic DNA No translation available.
BC163334 mRNA Translation: AAI63334.1
BC163336 mRNA Translation: AAI63336.1
EF527261 mRNA Translation: ABP88965.1
RefSeqiNP_001091053.1, NM_001097584.2
UniGeneiDr.105269
Dr.118654

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111043

Proteomic databases

PRIDEiA5A4L9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000126840; ENSDARP00000111043; ENSDARG00000079949
ENSDART00000172830; ENSDARP00000142119; ENSDARG00000079949
ENSDART00000177863; ENSDARP00000143354; ENSDARG00000079949
GeneIDi562348
KEGGidre:562348

Organism-specific databases

CTDi11198
ZFINiZDB-GENE-031118-96 supt16h

Phylogenomic databases

eggNOGiKOG1189 Eukaryota
COG5406 LUCA
GeneTreeiENSGT00390000014495
HOGENOMiHOG000209079
HOVERGENiHBG092544
OMAiEPPFMVI
OrthoDBiEOG091G044Q
TreeFamiTF300341

Enzyme and pathway databases

ReactomeiR-DRE-112382 Formation of RNA Pol II elongation complex
R-DRE-674695 RNA Polymerase II Pre-transcription Events
R-DRE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DRE-6804756 Regulation of TP53 Activity through Phosphorylation
R-DRE-75955 RNA Polymerase II Transcription Elongation

Gene expression databases

BgeeiENSDARG00000079949 Expressed in 28 organ(s), highest expression level in testis

Family and domain databases

CDDicd01091 CDC68-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.350.10, 1 hit
InterProiView protein in InterPro
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR013719 DUF1747
IPR029148 FACT-Spt16_Nlobe
IPR013953 FACT_Spt16p
IPR000994 Pept_M24
IPR011993 PH-like_dom_sf
IPR033825 SPT16
PfamiView protein in Pfam
PF14826 FACT-Spt16_Nlob, 1 hit
PF00557 Peptidase_M24, 1 hit
PF08512 Rtt106, 1 hit
PF08644 SPT16, 1 hit
SMARTiView protein in SMART
SM01285 FACT-Spt16_Nlob, 1 hit
SM01287 Rtt106, 1 hit
SM01286 SPT16, 1 hit
SUPFAMiSSF55920 SSF55920, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA5A4L9_DANRE
AccessioniPrimary (citable) accession number: A5A4L9
Secondary accession number(s): E7F5E9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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