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Entry version 94 (13 Feb 2019)
Sequence version 1 (29 May 2007)
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Protein
Submitted name:

FACT complex large subunit

Gene

supt16h

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: GO_Central
  • nucleosome binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-112382 Formation of RNA Pol II elongation complex
R-DRE-674695 RNA Polymerase II Pre-transcription Events
R-DRE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DRE-6804756 Regulation of TP53 Activity through Phosphorylation
R-DRE-75955 RNA Polymerase II Transcription Elongation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FACT complex large subunitImported
Submitted name:
SPT16 homolog, facilitates chromatin-remodeling subunitImported
Submitted name:
Suppressor of Ty 16 homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:supt16hImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-031118-96 supt16h

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000079949 Expressed in 28 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A5A4L9 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000111043

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 168FACT-Spt16_NlobInterPro annotationAdd BLAST164
Domaini530 – 690SPT16InterPro annotationAdd BLAST161
Domaini807 – 897Rtt106InterPro annotationAdd BLAST91

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1189 Eukaryota
COG5406 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000209079

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG092544

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPPFMVI

Database of Orthologous Groups

More...
OrthoDBi
145488at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300341

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01091 CDC68-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.40.350.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR013719 DUF1747
IPR029148 FACT-Spt16_Nlobe
IPR013953 FACT_Spt16
IPR000994 Pept_M24
IPR011993 PH-like_dom_sf
IPR040258 Spt16
IPR033825 Spt16_M24

The PANTHER Classification System

More...
PANTHERi
PTHR13980 PTHR13980, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14826 FACT-Spt16_Nlob, 1 hit
PF00557 Peptidase_M24, 1 hit
PF08512 Rtt106, 1 hit
PF08644 SPT16, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01285 FACT-Spt16_Nlob, 1 hit
SM01287 Rtt106, 1 hit
SM01286 SPT16, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55920 SSF55920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A5A4L9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSLDKDAF YRRIKRLYGN WKKGEDEFGK VDAIVVSVGV DEEIVYAKST
60 70 80 90 100
ALQTWLFGYE LTDTIMVFCE SKIIFLASKK KVEFLKQVAV TKGNENANGV
110 120 130 140 150
PPITLLVREK NESNKVNFDK MIEAIRGSKE GKTVGVFIKD KFPGEYMKSW
160 170 180 190 200
SDTITAEGLQ KVDISTVVAY TMAVKEDGEL ALMKKAASIT TDVFSKFFKE
210 220 230 240 250
RVMEIVDADE KVKHSRLAES VEKAIEDRKF LGGVDPSTVE MCYPPIIQSG
260 270 280 290 300
GNYSLKFSVV SDKNHMHFGA ITCAMGIRYK SYCSNLVRTL MVDPSQEMQD
310 320 330 340 350
NYNFLLQVEE ELLKEMKHGV KLSEAYNAVM EFVKKEKPDL VSKLTKNLGF
360 370 380 390 400
AMGIEFREGS LVINQKNQFK LKRGMVFSIS LGFADMINKE GKKEEQKKYA
410 420 430 440 450
LFIGDTIQIN EEDQATVLTP VKKKIKNVGI FLKNDDEDED EEEGDNAEEL
460 470 480 490 500
LGKGARSAAL LADRTRNEMT AEEKRRTHQK ELANQVNEEA KRRLTEQKGG
510 520 530 540 550
QQIQKVRKSN VSYKNVSQMP KEKDIRDMKI FIDKKHETVI MPVFGIATPF
560 570 580 590 600
HIATIKNISM SVEGDYTYLR INFFVPGSSL GRHEGNIFPN PEATFVKEIT
610 620 630 640 650
YRASNLKSPG DHSVPSTNLQ NAFRIIKEVQ KRYKTREAEE KEKEGIVKQD
660 670 680 690 700
SLVINLNRSN PKLKDLYIRP NIAQKRMQGS LEAHTNGFRF TSVRGDKVDI
710 720 730 740 750
LYNNIKHAIF QPCDGEMIIV LHFHLKNAIM FGKKRHTDVQ FYTEVGEITT
760 770 780 790 800
DLGKHQHMHD RDDLYAEQME REMRHKLKSA FKNFIEKVES LTKEELEFEV
810 820 830 840 850
PFRDLGFQGA PYRSTCLLQP TSSSLCNVTE WPPFVVTLDE VELVHFERVQ
860 870 880 890 900
FHLKNFDVVI VYKDYNKKVT MINAVPVNSL DPIKEWLNSC DIKYTEGIQS
910 920 930 940 950
LNWTKIMKTI VDDPEGFFEQ GGWSFLDPES EGSGGEEDSE SEIEDETFNP
960 970 980 990 1000
SADEEEEEEE DSDEDYSSET EDSDYSASLG SEEESGKDWD ELEEEARKAD
1010 1020 1030
RESQYEEVEE TSNRKRKGRS SAPPPRSKKK RRH
Length:1,033
Mass (Da):118,184
Last modified:May 29, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F5BC6E88DB308A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8QKY6A0A2R8QKY6_DANRE
SPT16 homolog, facilitates chromati...
supt16h
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX248243 Genomic DNA No translation available.
CABZ01078837 Genomic DNA No translation available.
BC163334 mRNA Translation: AAI63334.1
BC163336 mRNA Translation: AAI63336.1
EF527261 mRNA Translation: ABP88965.1

NCBI Reference Sequences

More...
RefSeqi
NP_001091053.1, NM_001097584.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.105269
Dr.118654

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000126840; ENSDARP00000111043; ENSDARG00000079949
ENSDART00000172830; ENSDARP00000142119; ENSDARG00000079949
ENSDART00000177863; ENSDARP00000143354; ENSDARG00000079949

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
562348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:562348

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248243 Genomic DNA No translation available.
CABZ01078837 Genomic DNA No translation available.
BC163334 mRNA Translation: AAI63334.1
BC163336 mRNA Translation: AAI63336.1
EF527261 mRNA Translation: ABP88965.1
RefSeqiNP_001091053.1, NM_001097584.2
UniGeneiDr.105269
Dr.118654

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111043

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000126840; ENSDARP00000111043; ENSDARG00000079949
ENSDART00000172830; ENSDARP00000142119; ENSDARG00000079949
ENSDART00000177863; ENSDARP00000143354; ENSDARG00000079949
GeneIDi562348
KEGGidre:562348

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11198
ZFINiZDB-GENE-031118-96 supt16h

Phylogenomic databases

eggNOGiKOG1189 Eukaryota
COG5406 LUCA
GeneTreeiENSGT00390000014495
HOGENOMiHOG000209079
HOVERGENiHBG092544
OMAiEPPFMVI
OrthoDBi145488at2759
TreeFamiTF300341

Enzyme and pathway databases

ReactomeiR-DRE-112382 Formation of RNA Pol II elongation complex
R-DRE-674695 RNA Polymerase II Pre-transcription Events
R-DRE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DRE-6804756 Regulation of TP53 Activity through Phosphorylation
R-DRE-75955 RNA Polymerase II Transcription Elongation

Gene expression databases

BgeeiENSDARG00000079949 Expressed in 28 organ(s), highest expression level in testis
ExpressionAtlasiA5A4L9 baseline

Family and domain databases

CDDicd01091 CDC68-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.350.10, 1 hit
InterProiView protein in InterPro
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR013719 DUF1747
IPR029148 FACT-Spt16_Nlobe
IPR013953 FACT_Spt16
IPR000994 Pept_M24
IPR011993 PH-like_dom_sf
IPR040258 Spt16
IPR033825 Spt16_M24
PANTHERiPTHR13980 PTHR13980, 1 hit
PfamiView protein in Pfam
PF14826 FACT-Spt16_Nlob, 1 hit
PF00557 Peptidase_M24, 1 hit
PF08512 Rtt106, 1 hit
PF08644 SPT16, 1 hit
SMARTiView protein in SMART
SM01285 FACT-Spt16_Nlob, 1 hit
SM01287 Rtt106, 1 hit
SM01286 SPT16, 1 hit
SUPFAMiSSF55920 SSF55920, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA5A4L9_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5A4L9
Secondary accession number(s): E7F5E9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: February 13, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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