UniProtKB - A4ZVS7 (A4ZVS7_HUMAN)
Protein
Submitted name:
Protein inhibitor of activated STAT1
Gene
PIAS1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 320 – 397 | SP-RING-typePROSITE-ProRule annotationAdd BLAST | 78 |
GO - Molecular functioni
- zinc ion binding Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Protein inhibitor of activated STAT1Imported |
Gene namesi | Name:PIAS1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 45 | SAPInterPro annotationAdd BLAST | 35 | |
Domaini | 124 – 288 | PINITInterPro annotationAdd BLAST | 165 | |
Domaini | 320 – 397 | SP-RING-typeInterPro annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 465 – 511 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 599 – 632 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 480 – 511 | PolarSequence analysisAdd BLAST | 32 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 320 – 397 | SP-RING-typePROSITE-ProRule annotationAdd BLAST | 78 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG2169 Eukaryota ENOG410XQ2E LUCA |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 2.60.120.780, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR023321 PINIT IPR038654 PINIT_sf IPR003034 SAP_dom IPR036361 SAP_dom_sf IPR004181 Znf_MIZ IPR013083 Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF14324 PINIT, 1 hit PF02891 zf-MIZ, 1 hit |
SMARTi | View protein in SMART SM00513 SAP, 1 hit |
SUPFAMi | SSF68906 SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51466 PINIT, 1 hit PS50800 SAP, 1 hit PS51044 ZF_SP_RING, 1 hit |
i Sequence
Sequence statusi: Complete.
A4ZVS7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADSAELKQM VMSLRVSGLQ VLLGYAGRNK HGRKHELLTK ALHLLKAGCS
60 70 80 90 100
PAVQMKIKEL YRRRFPQKIM TPADLSIPNV HSSPMPATLS PSTIPQLTYD
110 120 130 140 150
GHPASSPLLP VSLLGPKHEL ELPHLTSALH PVHPDIKLQK LPFYDLLDEL
160 170 180 190 200
IKPTSLASDN SQRFRETCFA FALTPQQVQQ ISSSMDISGT KCDFTVQVQL
210 220 230 240 250
RFCLSETSCP QEDHFPPNLC VKVNTKPCSL PGYLPPTKNG VEPKRPSRPI
260 270 280 290 300
NITSLVRLST TVPNTIVVSW TAEIGRNYSM AVYLVKQLSS TVLLQRLRAK
310 320 330 340 350
GIRNPDHSRA LIKEKLTADP DSEIATTSLR VSLLCPLGKM RLTIPCRALT
360 370 380 390 400
CSHLQCFDAT LYIQMNEKKP TWVCPVCDKK APYEHLIIDG LFMEILKYCT
410 420 430 440 450
DCDEIQFKED GTWAPMRSKK EVQEVSASYN GVDGCLSSTL EHQVASHHQS
460 470 480 490 500
SNKNKKVEVI DLTIDSSSDE EEEEPSAKRT CPSLSPTSPL NNKGILSLPH
510 520 530 540 550
QASPVSRTPS LPAVDTSYIN TSLIQDYRHP FHMTPMPYDL QGLDFFPFLS
560 570 580 590 600
GDNQHYNTSL LAAAAAAVSD DQDLLHSSRF FPYTSSQMFL DQLSAGGSTS
610 620 630 640 650
LPTTNGSSSG SNSSLVSSNS LRESHSHTVT NRSSTDTASI FGIIPDIISL
D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF487997 mRNA Translation: ABP49565.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF487997 mRNA Translation: ABP49565.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A4ZVS7, 1 interactor |
Proteomic databases
PeptideAtlasi | A4ZVS7 |
PRIDEi | A4ZVS7 |
Phylogenomic databases
eggNOGi | KOG2169 Eukaryota ENOG410XQ2E LUCA |
Miscellaneous databases
ChiTaRSi | PIAS1 human |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 2.60.120.780, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR023321 PINIT IPR038654 PINIT_sf IPR003034 SAP_dom IPR036361 SAP_dom_sf IPR004181 Znf_MIZ IPR013083 Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF14324 PINIT, 1 hit PF02891 zf-MIZ, 1 hit |
SMARTi | View protein in SMART SM00513 SAP, 1 hit |
SUPFAMi | SSF68906 SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51466 PINIT, 1 hit PS50800 SAP, 1 hit PS51044 ZF_SP_RING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A4ZVS7_HUMAN | |
Accessioni | A4ZVS7Primary (citable) accession number: A4ZVS7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 29, 2007 |
Last sequence update: | May 29, 2007 | |
Last modified: | July 31, 2019 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |