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Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

gap

Organism
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (Msed_1412)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109NAD; via amide nitrogenUniRule annotation1
Active sitei139NucleophileUniRule annotation1
Binding sitei167NADUniRule annotation1
Binding sitei300NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 12NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandNAD, NADP

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00184

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.59UniRule annotation)
Short name:
GAPDHUniRule annotation
Alternative name(s):
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gapUniRule annotation
Ordered Locus Names:Msed_1652
OrganismiMetallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
Taxonomic identifieri399549 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000000242 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000725621 – 340Glyceraldehyde-3-phosphate dehydrogenaseAdd BLAST340

Proteomic databases

PRIDEiA4YHA5

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi399549.Msed_1652

Structurei

3D structure databases

ProteinModelPortaliA4YHA5
SMRiA4YHA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 140Glyceraldehyde 3-phosphate bindingUniRule annotation3
Regioni193 – 194Glyceraldehyde 3-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00493 Archaea
COG0057 LUCA
HOGENOMiHOG000223361
KOiK00150
OMAiNAIVPNP
OrthoDBiPOG093Z05Z6

Family and domain databases

HAMAPiMF_00559 G3P_dehdrog_arch, 1 hit
InterProiView protein in InterPro
IPR000846 DapB_N
IPR020831 GlycerAld/Erythrose_P_DH
IPR020830 GlycerAld_3-P_DH_AS
IPR020829 GlycerAld_3-P_DH_cat
IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
IPR006436 Glyceraldehyde-3-P_DH_2_arc
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR10836 PTHR10836, 1 hit
PTHR10836:SF76 PTHR10836:SF76, 1 hit
PfamiView protein in Pfam
PF01113 DapB_N, 1 hit
PF02800 Gp_dh_C, 1 hit
PIRSFiPIRSF000149 GAP_DH, 1 hit
SMARTiView protein in SMART
SM00846 Gp_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01546 GAPDH-II_archae, 1 hit
PROSITEiView protein in PROSITE
PS00071 GAPDH, 1 hit

Sequencei

Sequence statusi: Complete.

A4YHA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKVAVNGYG TIGKRVASAI LAQPDMTLVG VSKTSPNYEA YQAQKMGINL
60 70 80 90 100
YVTKESLKEF EEAGIKVKGV LEDMIKEADV VVDATPNGVG AQYKQVYSSM
110 120 130 140 150
GKRALFQGGE KANVADVSFS ALCNYDEAVD KRYVRVVSCN TTGLLRTLCT
160 170 180 190 200
LNRVSKIAKV RGTIVRRAAD PKEVKKGPIN SLVPDPASIP SHHAKDVNTV
210 220 230 240 250
LKDLDIVTMA VVAPTTLMHV HLLDVTVSSP VTKEDVLSVL SSTPRILLAS
260 270 280 290 300
GKSKVSSTAE IVEVARDMGR PRNDLYELVV FEDSVSVRGN EVFLMYAVHQ
310 320 330 340
ESIVVPENVD AIRAVSGFAD GRKSIEMTNA SMGIGKGYLV
Length:340
Mass (Da):36,648
Last modified:May 29, 2007 - v1
Checksum:i997600B78F9101A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA Translation: ABP95807.1
RefSeqiWP_012021594.1, NC_009440.1

Genome annotation databases

EnsemblBacteriaiABP95807; ABP95807; Msed_1652
GeneIDi5104857
KEGGimse:Msed_1652

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000682 Genomic DNA Translation: ABP95807.1
RefSeqiWP_012021594.1, NC_009440.1

3D structure databases

ProteinModelPortaliA4YHA5
SMRiA4YHA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399549.Msed_1652

Proteomic databases

PRIDEiA4YHA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP95807; ABP95807; Msed_1652
GeneIDi5104857
KEGGimse:Msed_1652

Phylogenomic databases

eggNOGiarCOG00493 Archaea
COG0057 LUCA
HOGENOMiHOG000223361
KOiK00150
OMAiNAIVPNP
OrthoDBiPOG093Z05Z6

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00184

Family and domain databases

HAMAPiMF_00559 G3P_dehdrog_arch, 1 hit
InterProiView protein in InterPro
IPR000846 DapB_N
IPR020831 GlycerAld/Erythrose_P_DH
IPR020830 GlycerAld_3-P_DH_AS
IPR020829 GlycerAld_3-P_DH_cat
IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
IPR006436 Glyceraldehyde-3-P_DH_2_arc
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR10836 PTHR10836, 1 hit
PTHR10836:SF76 PTHR10836:SF76, 1 hit
PfamiView protein in Pfam
PF01113 DapB_N, 1 hit
PF02800 Gp_dh_C, 1 hit
PIRSFiPIRSF000149 GAP_DH, 1 hit
SMARTiView protein in SMART
SM00846 Gp_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01546 GAPDH-II_archae, 1 hit
PROSITEiView protein in PROSITE
PS00071 GAPDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3P_METS5
AccessioniPrimary (citable) accession number: A4YHA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 29, 2007
Last modified: October 10, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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