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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciPMEN399739:PMEN_RS18290-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesi
Name:lldDUniRule annotation
Ordered Locus Names:Pmen_3635
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000229 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000689911 – 379L-lactate dehydrogenaseAdd BLAST379

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi399739.Pmen_3635

Structurei

3D structure databases

ProteinModelPortaliA4XYG7
SMRiA4XYG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 379FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST379

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMF Bacteria
COG1304 LUCA
HOGENOMiHOG000217464
KOiK00101
OMAiMQLYIYK
OrthoDBiPOG091H00L7

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01559 L_lact_dehydr, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
IPR020920 LldD
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4XYG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIISASTDYR AAAERKLPPF LFHYADGGAY AEHTLRRNVA DLSNIELRQR
60 70 80 90 100
VLKNMSELDL STELFGEKMS MPVGLAPVGL TGMYARRGEV QAAKAAAAKG
110 120 130 140 150
IPFTLSTVSV CPIEEVAPAI DRPMWFQLYV LKDRGFMRNA LERAKAAGCS
160 170 180 190 200
TLVFTVDMPV PGARYRDAHS GMSGPNGPLR RVLQAMTHPQ WAWDVGVMGK
210 220 230 240 250
PHDLGNISAY RGNPTGLADY IGWLGANFDP SISWKDLEWI RDFWDGPMVI
260 270 280 290 300
KGILDPEDAR DAVTFGADGI IVSNHGGRQL DGVLSSARAL PAIADAVKGE
310 320 330 340 350
LKILADSGIR TGLDVVRMLA LGADTVLLGR AFIYALAVAG QAGVSNLLDL
360 370
IEKEMRVAMV LTGAKSIAEI TSDLLVKER
Length:379
Mass (Da):40,949
Last modified:May 29, 2007 - v1
Checksum:i49E1743B64C68E3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA Translation: ABP86383.1
RefSeqiWP_003240516.1, NC_009439.1

Genome annotation databases

EnsemblBacteriaiABP86383; ABP86383; Pmen_3635
GeneIDi5110096
KEGGipmy:Pmen_3635
PATRICifig|399739.8.peg.3684

Similar proteinsi

Entry informationi

Entry nameiLLDD_PSEMY
AccessioniPrimary (citable) accession number: A4XYG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: June 20, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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