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Protein

3-ketoacyl-CoA thiolase

Gene

fadA

Organism
Pseudomonas mendocina (strain ymp)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Acyl-thioester intermediateUniRule annotation1
Active sitei347Proton acceptorUniRule annotation1
Active sitei377Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayi
UPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
Acetyl-CoA acyltransferaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadAUniRule annotation
Ordered Locus Names:Pmen_1581
OrganismiPseudomonas mendocina (strain ymp)
Taxonomic identifieri399739 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000229 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003235491 – 3913-ketoacyl-CoA thiolaseAdd BLAST391

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Protein-protein interaction databases

STRINGi399739.Pmen_1581

Structurei

3D structure databases

ProteinModelPortaliA4XSM9
SMRiA4XSM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU Bacteria
COG0183 LUCA
HOGENOMiHOG000012239
KOiK00632
OMAiCGGTESM
OrthoDBiPOG091H0I7B

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
HAMAPiMF_01620 FadA, 1 hit
InterProiView protein in InterPro
IPR012805 FadA
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
TIGR02445 fadA, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4XSM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLNPRDAVI VDFGRTPMGR SKGGMHRNTR AETMSAHLIS KVLERNAKID
60 70 80 90 100
PAEVEDVIWG CVNQTLEQGW NIARMASLMT QIPHTSAGQT VSRLCGSSMS
110 120 130 140 150
ALHTAVQAIQ TGNGDVFVVG GVEHMGHVGM MHGVDPNPHL SLYAAKASGM
160 170 180 190 200
MGLTAEMLGK MHGISREAQD AFGERSHRLA HKATVEGKFK DEIIPMQGYD
210 220 230 240 250
ENGFLKVFDY DETIRPETTL ESLATLKPAF NPKGGTVTAG TSSQITDGAS
260 270 280 290 300
CMIVMSAQRA QDLGIQPMAV VRAMAVAGVD PAIMGYGPVP STQKALKRAG
310 320 330 340 350
LTMADIDFVE LNEAFAAQAL PVLKDLKLLD KMEEKVNLHG GAIALGHPFG
360 370 380 390
CSGARISGTL LNVMKQNGGT LGVSTMCVGL GQGITTVFER V
Length:391
Mass (Da):41,529
Last modified:May 29, 2007 - v1
Checksum:i26A3371E196A87DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000680 Genomic DNA Translation: ABP84345.1
RefSeqiWP_003245266.1, NC_009439.1

Genome annotation databases

EnsemblBacteriaiABP84345; ABP84345; Pmen_1581
GeneIDi5109239
KEGGipmy:Pmen_1581
PATRICifig|399739.8.peg.1603

Similar proteinsi

Entry informationi

Entry nameiFADA_PSEMY
AccessioniPrimary (citable) accession number: A4XSM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 29, 2007
Last modified: June 20, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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