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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei732ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Strop_3225
OrganismiSalinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
Taxonomic identifieri369723 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeSalinispora
Proteomesi
  • UP000000235 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913621 – 954Leucine--tRNA ligaseAdd BLAST954

Proteomic databases

PRIDEiA4X9S8

Interactioni

Protein-protein interaction databases

STRINGi369723.Strop_3225

Structurei

3D structure databases

ProteinModelPortaliA4X9S8
SMRiA4X9S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi67 – 78"HIGH" regionAdd BLAST12
Motifi729 – 733"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A4X9S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAAAPASD IPPFRYTADL ADEIERRWQD TWEREGTFHA PNPTGPLADP
60 70 80 90 100
EHPRAGAEKL YVLDMFPYPS GAGLHVGHPL GYIGTDCFAR YQRMAGRNVL
110 120 130 140 150
HAMGFDAFGL PAEQYAVQTG THPRTTTEAN IARYKAQLRR LGLAHDERRS
160 170 180 190 200
VATIDADFYR WTQWVFLQIY NAWYDSSAKR ARPIAELVAE FSGGSRRTPD
210 220 230 240 250
GRPWGELTDA ERRAVVDQHR LAYVSQAPVN WCPGLGTVLA NEEVTADGRS
260 270 280 290 300
ERGNFPVFKR NLKQWMMRIT AYGDRLLDDL EKLDWPEPIK LMQRNWIGRS
310 320 330 340 350
TGAHIEFPTS APDSDAEGEP RISVFTTRPD TIFGATYLVL APEHDLVDTL
360 370 380 390 400
VPTAWPAGVP QAWTGGQASP REAVAGYRKV AAAKTDLERQ AETKEKTGVF
410 420 430 440 450
IGSYATNPVT GAQIPIFIAD YVLAGYGTGA IMAVPGQDER DWAFAEVFDL
460 470 480 490 500
PIVRTVQPAE GFAGKAYTGD GLAINSATPE RGLDLNGLGV AEAKARTIAW
510 520 530 540 550
LEAGGHGSGA VTYRLRDWLF SRQRYWGEPF PIVYDETGAA IALPEELLPV
560 570 580 590 600
ELPEVDDFAP RTFDPSDAES NPETPLSRRR DWVEVELDLG DGPKRYTRET
610 620 630 640 650
NVMPQWAGSC WYELRYLDPT NGDRFVDPEA ERYWMGPRGE GDCGGTDLYV
660 670 680 690 700
GGAEHAVLHL LYARFWHKVL YDLGHVSSFE PFRKLFNQGY IQAYAYTDAR
710 720 730 740 750
GAYVPAEEVV ERSGTYYLGD VQVNREYGKM GKSLRNVVTP DEMCAAYGAD
760 770 780 790 800
TFRVYEMSMG PLEVSRPWET RAVVGSFRFL QRVWRAIVDE RSGASRVVDV
810 820 830 840 850
PADEATRRLL HRIVDGVRGD MEAMRFNTTI AKLIELTNAL TRLPETPREV
860 870 880 890 900
AEPLVLMLAP FAPHVAEELW RRMGHETSLT YADFPVADPA LLVAESVTYP
910 920 930 940 950
VQVNGKVRGR IEVPADAGQE TVRAAALEAV AASLAGKEPR KVIVVPGRMV

SVVA
Length:954
Mass (Da):106,010
Last modified:May 29, 2007 - v1
Checksum:i46A367CA446A4CB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000667 Genomic DNA Translation: ABP55659.1
RefSeqiWP_012014436.1, NC_009380.1

Genome annotation databases

EnsemblBacteriaiABP55659; ABP55659; Strop_3225
GeneIDi5059690
KEGGistp:Strop_3225
PATRICifig|369723.5.peg.3317

Similar proteinsi

Entry informationi

Entry nameiSYL_SALTO
AccessioniPrimary (citable) accession number: A4X9S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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