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Protein

Argininosuccinate lyase

Gene

argH

Organism
Enterobacter sp. (strain 638)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argI), Ornithine carbamoyltransferase (argI)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Ent638_4026
OrganismiEnterobacter sp. (strain 638)
Taxonomic identifieri399742 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacter
Proteomesi
  • UP000000230 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000570501 – 457Argininosuccinate lyaseAdd BLAST457

Proteomic databases

PRIDEiA4WG51

Interactioni

Protein-protein interaction databases

STRINGi399742.Ent638_4026

Structurei

3D structure databases

ProteinModelPortaliA4WG51
SMRiA4WG51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A4WG51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWGGRFTQ AADQRFKQFN DSLRFDYRLA EQDIVGSVAW SKALVTVGVL
60 70 80 90 100
SADEQVQLEE ALNNLLEEVR LNPQQILESD AEDIHSWVEG KLIDKVGQLG
110 120 130 140 150
KKLHTGRSRN DQVATDLKLW CKDTIVELLS ANRQLQNALV ETAQNNQDAV
160 170 180 190 200
MPGYTHLQRA QPVTFAHWSL AYVEMLARDE SRLQDTLKRL DVSPLGSGAL
210 220 230 240 250
AGTAYEIDRE QLAGWLGFAS ATRNSLDSVS DRDHVLELLS NASIGMVHLS
260 270 280 290 300
RFAEDLIFFN SGEAGFVELS DRVTSGSSLM PQKKNPDALE LIRGKCGRVQ
310 320 330 340 350
GALTGMMMTL KGLPLAYNKD MQEDKEGLFD ALDTWLDCLH MGALVLDGIQ
360 370 380 390 400
VKRPRCQEAA QQGYANSTEL ADYLVAKGVP FREAHHIVGE AVVEAIRQGK
410 420 430 440 450
PLEDLTLADL QKFSAVIGDD VYPILSLQSC LDKRAAKGGV SPKQVAQAIA

DAKSRLV
Length:457
Mass (Da):50,302
Last modified:May 29, 2007 - v1
Checksum:iFF9A617F8CA468FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA Translation: ABP62681.1
RefSeqiWP_015960985.1, NC_009436.1

Genome annotation databases

EnsemblBacteriaiABP62681; ABP62681; Ent638_4026
GeneIDi32441743
KEGGient:Ent638_4026

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000653 Genomic DNA Translation: ABP62681.1
RefSeqiWP_015960985.1, NC_009436.1

3D structure databases

ProteinModelPortaliA4WG51
SMRiA4WG51
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi399742.Ent638_4026

Proteomic databases

PRIDEiA4WG51

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP62681; ABP62681; Ent638_4026
GeneIDi32441743
KEGGient:Ent638_4026

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00114

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARLY_ENT38
AccessioniPrimary (citable) accession number: A4WG51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 29, 2007
Last modified: October 10, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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