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UniProtKB - A4V1B2 (A4V1B2_DROME)

Entry version 120 (19 Jan 2022)
Sequence version 1 (29 May 2007)
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Protein
Submitted name:

Patj, isoform B

Gene

Patj

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Patj, isoform BImported
Submitted name:
Patj, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PatjImported
Synonyms:BcDNA:LD22238Imported, D-PatjImported, DLTImported, DltImported, dltImported, dlt:discs lostImported, Dmel\CG12021Imported, DPATJImported, DPatjImported, DpatjImported, dPATJImported, dPatjImported, dpatjImported, PATJImported, PaTJImported, PatJImported, patjImported
ORF Names:CG12021Imported, Dmel_CG12021Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0067864, Patj

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0067864

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0067864, Expressed in embryo and 23 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 67L27InterPro annotationAdd BLAST65
Domaini149 – 229PDZInterPro annotationAdd BLAST81
Domaini318 – 403PDZInterPro annotationAdd BLAST86
Domaini559 – 648PDZInterPro annotationAdd BLAST90
Domaini728 – 806PDZInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni100 – 134DisorderedSequence analysisAdd BLAST35
Regioni420 – 453DisorderedSequence analysisAdd BLAST34
Regioni822 – 871DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi434 – 451Polar residuesSequence analysisAdd BLAST18
Compositional biasi822 – 838Polar residuesSequence analysisAdd BLAST17
Compositional biasi843 – 857Pro residuesSequence analysisAdd BLAST15

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006771_1_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		SEIVRKW

Database of Orthologous Groups

More...OrthoDBi		532163at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004172, L27_dom
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00595, PDZ, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00569, L27, 1 hit
SM00228, PDZ, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51022, L27, 1 hit
PS50106, PDZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A4V1B2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLSADISSA LQQIEAVKKG IDESDDPKLQ MQTAESLSTI LGILQDPVFR 
        60         70         80         90        100
TIVHVQDSLS ELNAQLAQHP SMLPNDFDID VAGNLVLSLN GGEVMYDFDE 
       110        120        130        140        150
QRSSSHSHSA PGSPDKSGGV GEEPRPQSQN SKGAGVADLY ATDYAQIQAI 
       160        170        180        190        200
ELVNDGTGLG FGIIGARNSG VIVKTILPGG VADKDGRLRS GDHILQIGDV 
       210        220        230        240        250
NLHEMVSEQV AAVLRQSGTH VRLVVARPVE QSVPTPQYAL EPGTAVVPTR 
       260        270        280        290        300
VLVDPAELER YLISTGYPEI FGESSTASTP QTTTEDDRFV YRGETSMLID 
       310        320        330        340        350
PNIDLEELLA LPETEKLQVE LKKDANGLGI TIAGYVCEKE ELSGIFVKSV 
       360        370        380        390        400
SPGSAADLSG RIRVNDRIIE VDGQSLQGYS NHQAVELLKK SGQVVNLRLE 
       410        420        430        440        450
RYLRGPKFEQ LQQAIAANDK LPSSAPGTPS RAPMPTPVAT TSSATTTPSR 
       460        470        480        490        500
SITRELEEEA LPAPEAFMTT PPSVTTMTTT TLSSFGAGKQ LVAVRDSLDG 
       510        520        530        540        550
STKIIPTEVV PLADKTEAKN SGVITRHKYY TDPELSDDAE TEIIRKWQKI 
       560        570        580        590        600
VGSDVEVIVA QIKKFAVGGL GISLEGTVDV EGGREVRPHH YIRSILPDGP 
       610        620        630        640        650
VGVNGVLRSG DELLEVNGER LLGMNHLEVV AILKELPLDV RMVCGRNRNS 
       660        670        680        690        700
SLLPFSDDTL KKLSNNFENL LPATDRLVKA KSDGSLATAG SVADGDSVAA 
       710        720        730        740        750
AAASFSKLKS RSLEPLTGLA MWSSQPQIIE LVKGDRGLGF SILDYQDPLD 
       760        770        780        790        800
PNDTLIVIRS LVPGGVAQLD GRLIPGDRLL FVNSINLENA SLDQAVQALK 
       810        820        830        840        850
GASKGVVRIG VAKPLPMTDN SLKACSNAST TSEETLDAQP SPPALPTVAP 
       860        870 
PAMPPSASMG AEPDLIPDWR N
Length:871
Mass (Da):92,852
Last modified:May 29, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE41E80AA2925B4D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NB04PATJ_DROME
Patj homolog
Patj CG12021
871Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47573.1
AE014296 Genomic DNA Translation: AAG22224.1

NCBI Reference Sequences

More...RefSeqi		NP_477342.1, NM_057994.5
NP_599144.1, NM_134317.4
NP_728674.1, NM_167917.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0072779; FBpp0072662; FBgn0067864
FBtr0072781; FBpp0072664; FBgn0067864
FBtr0301625; FBpp0290839; FBgn0067864

Database of genes from NCBI RefSeq genomes

More...GeneIDi		44100

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG12021

UCSC genome browser

More...UCSCi		CG12021-RB, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47573.1
AE014296 Genomic DNA Translation: AAG22224.1
RefSeqiNP_477342.1, NM_057994.5
NP_599144.1, NM_134317.4
NP_728674.1, NM_167917.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		44100

Genome annotation databases

EnsemblMetazoaiFBtr0072779; FBpp0072662; FBgn0067864
FBtr0072781; FBpp0072664; FBgn0067864
FBtr0301625; FBpp0290839; FBgn0067864
GeneIDi44100
KEGGidme:Dmel_CG12021
UCSCiCG12021-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10207
FlyBaseiFBgn0067864, Patj
VEuPathDBiVectorBase:FBgn0067864

Phylogenomic databases

HOGENOMiCLU_006771_1_0_1
OMAiSEIVRKW
OrthoDBi532163at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		44100, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		lost, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		44100

Gene expression databases

BgeeiFBgn0067864, Expressed in embryo and 23 other tissues

Family and domain databases

Gene3Di2.30.42.10, 4 hits
InterProiView protein in InterPro
IPR004172, L27_dom
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF00595, PDZ, 4 hits
SMARTiView protein in SMART
SM00569, L27, 1 hit
SM00228, PDZ, 4 hits
SUPFAMiSSF50156, SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS51022, L27, 1 hit
PS50106, PDZ, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4V1B2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4V1B2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: January 19, 2022
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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