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UniProtKB - A4V133 (A4V133_DROME)
Protein
Calcium/calmodulin-dependent protein kinase
Gene
CaMKII
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- calmodulin binding Source: UniProtKB-KW
- calmodulin-dependent protein kinase activity Source: UniProtKB-EC
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation, Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium/calmodulin-dependent protein kinaseARBA annotation (EC:2.7.11.17ARBA annotation) |
Gene namesi | Name:CaMKIIImported Synonyms:Ca2+Imported, CalciumImported, calciumImported, CaMImported, CamImported, CaM IIImported, CaM KIIImported, CaM kinaseImported, CaMK IIImported, CaMK-IIImported, CAMKIIImported, CamKIIImported, CamkiiImported, camKIIImported, camkIIImported, CaMKII-RAImported, CAMKIIalphaImported, CamKIIalphaImported, CAMKIIdImported, CDPK1Imported, dCAMKIIImported, dCaMKIIImported, DCKImported, Dmel\CG18069Imported, l(4)102EFbImported, l(4)16Imported, l(4)arImported ORF Names:CG18069Imported, Dmel_CG18069Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0264607, CaMKII |
VEuPathDBi | VectorBase:FBgn0264607 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 272 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 320 – 342 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 320 – 335 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.ARBA annotation
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
A4V133-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPAACTRF SDNYDIKEEL GKGAFSIVKR CVQKSTGFEF AAKIINTKKL
60 70 80 90 100
TARDFQKLER EARICRKLHH PNIVRLHDSI QEENYHYLVF DLVTGGELFE
110 120 130 140 150
DIVAREFYSE ADASHCIQQI LESVNHCHQN GVVHRDLKPE NLLLASKAKG
160 170 180 190 200
AAVKLADFGL AIEVQGDHQA WFGFAGTPGY LSPEVLKKEP YGKSVDIWAC
210 220 230 240 250
GVILYILLVG YPPFWDEDQH RLYSQIKAGA YDYPSPEWDT VTPEAKNLIN
260 270 280 290 300
QMLTVNPNKR ITAAEALKHP WICQRERVAS VVHRQETVDC LKKFNARRKL
310 320 330 340 350
KGAILTTMLA TRNFSSRSMI TKKGEGSQVK ESTDSSSTTL EDDDIKAARR
360 370 380 390 400
QEIIKITEQL IEAINSGDFD GYTKICDPHL TAFEPEALGN LVEGIDFHKF
410 420 430 440 450
YFENVLGKNC KAINTTILNP HVHLLGEEAA CIAYVRLTQY IDKQGHAHTH
460 470 480 490
QSEETRVWHK RDNKWQNVHF HRSASAKISG ATTFDFIPQK
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ00168 | KCC2A_DROME | Calcium/calmodulin-dependent protei... | CaMKII CaM, CG18069 | 530 | Annotation score: | ||
D1YSG7 | D1YSG7_DROME | Calcium/calmodulin-dependent protei... | CaMKII Ca2+, Calcium, calcium, CaM, Cam | 530 | Annotation score: | ||
A4V134 | A4V134_DROME | Calcium/calmodulin-dependent protei... | CaMKII Ca2+, Calcium, calcium, CaM, Cam | 509 | Annotation score: | ||
D1YSG8 | D1YSG8_DROME | Calcium/calmodulin-dependent protei... | CaMKII Ca2+, Calcium, calcium, CaM, Cam | 531 | Annotation score: | ||
L0MNA2 | L0MNA2_DROME | Calcium/calmodulin-dependent protei... | CaMKII Ca2+, Calcium, calcium, CaM, Cam | 482 | Annotation score: | ||
L0MLP2 | L0MLP2_DROME | Calcium/calmodulin-dependent protei... | CaMKII Ca2+, Calcium, calcium, CaM, Cam | 504 | Annotation score: | ||
L0MLR4 | L0MLR4_DROME | Calcium/calmodulin-dependent protei... | CaMKII Ca2+, Calcium, calcium, CaM, Cam | 522 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014135 Genomic DNA Translation: AAF59389.3 BT050453 mRNA Translation: ACJ13160.1 AE014135 Genomic DNA Translation: ACZ95100.1 |
RefSeqi | NP_001162831.1, NM_001169360.2 NP_524635.3, NM_079896.4 NP_726633.2, NM_166810.5 |
Genome annotation databases
EnsemblMetazoai | FBtr0089217; FBpp0088281; FBgn0264607 FBtr0089218; FBpp0088282; FBgn0264607 FBtr0300377; FBpp0289606; FBgn0264607 |
GeneIDi | 43828 |
UCSCi | CG18069-RC, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014135 Genomic DNA Translation: AAF59389.3 BT050453 mRNA Translation: ACJ13160.1 AE014135 Genomic DNA Translation: ACZ95100.1 |
RefSeqi | NP_001162831.1, NM_001169360.2 NP_524635.3, NM_079896.4 NP_726633.2, NM_166810.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 43828 |
Genome annotation databases
EnsemblMetazoai | FBtr0089217; FBpp0088281; FBgn0264607 FBtr0089218; FBpp0088282; FBgn0264607 FBtr0300377; FBpp0289606; FBgn0264607 |
GeneIDi | 43828 |
UCSCi | CG18069-RC, d. melanogaster |
Organism-specific databases
CTDi | 43828 |
FlyBasei | FBgn0264607, CaMKII |
VEuPathDBi | VectorBase:FBgn0264607 |
Miscellaneous databases
BioGRID-ORCSi | 43828, 0 hits in 3 CRISPR screens |
GenomeRNAii | 43828 |
Gene expression databases
Bgeei | FBgn0264607, Expressed in head and 55 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A4V133_DROME | |
Accessioni | A4V133Primary (citable) accession number: A4V133 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 29, 2007 |
Last sequence update: | May 29, 2007 | |
Last modified: | January 19, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |