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Entry version 94 (02 Jun 2021)
Sequence version 1 (03 Mar 2009)
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Protein
Submitted name:

Eps15 homology domain containing protein-binding protein 1, isoform F

Gene

Ehbp1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Eps15 homology domain containing protein-binding protein 1, isoform FImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ehbp1Imported
Synonyms:2R11Imported, dEHBP-1Imported, dEHBP1Imported, Dmel\CG15609Imported, EHBP1Imported, ehbp1Imported
ORF Names:CG15609Imported, Dmel_CG15609Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034180, Ehbp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A4UZL3

PRoteomics IDEntifications database

More...
PRIDEi
A4UZL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034180, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A4UZL3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A4UZL3, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0113119

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A4UZL3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 158C2 NT-typeInterPro annotationAdd BLAST151
Domaini458 – 563Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini789 – 1125BMERBInterPro annotationAdd BLAST337

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 340DisorderedSequence analysisAdd BLAST75
Regioni353 – 424DisorderedSequence analysisAdd BLAST72
Regioni653 – 708DisorderedSequence analysisAdd BLAST56
Regioni876 – 924DisorderedSequence analysisAdd BLAST49
Regioni990 – 1012DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili806 – 829Sequence analysisAdd BLAST24
Coiled coili1055 – 1075Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi273 – 292Polar residuesSequence analysisAdd BLAST20
Compositional biasi353 – 387Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi410 – 424Polar residuesSequence analysisAdd BLAST15
Compositional biasi889 – 916Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi994 – 1012Basic residuesSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0035, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170931

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004178_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4UZL3

Database of Orthologous Groups

More...
OrthoDBi
165311at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A4UZL3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR019448, NT-C2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF10358, NT-C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51848, BMERB, 1 hit
PS51840, C2_NT, 1 hit
PS50021, CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A4UZL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVWKRLQR NFKRAAKFQF TASYHDLHLE TTAKWRPSNL SIVWTRRSRR
60 70 80 90 100
VASAPLPWEP DMMNPLVGNI SWPVPDNHTI SVTLFKDPRT HELEDKDWTF
110 120 130 140 150
VIEDVTPMGK KRVLANASIN MRKYASIEST QQSFTLSLKP VSKKITAASL
160 170 180 190 200
ELTISCVFLR EGKATDEDMQ SVVSMMSVNN NDVAPLDDLE DIPDLDGFSE
210 220 230 240 250
ITDNFNDFTQ QLEHMTTSLN GCIDVATPQS VPSLSEDPTP LAESFNPLHF
260 270 280 290 300
ELDADGKREA ANKLDLPTAA SGGSSGAEES LKTPNGLQHV VDQTPIKSPD
310 320 330 340 350
EVKQPKQTPV ESLRSKTNED FDKMVTSTPL EPNVNKDDVK PKKKRALFFT
360 370 380 390 400
EKEDEQDLRV ESVKEDTTKT IGDNSTTKEK PKEESQSSKD ASSVVVPSAK
410 420 430 440 450
RPELQPLNLK KSYEPSQTPE SAPVPASVIN ESIGSCFSTS GSLNNSLKPV
460 470 480 490 500
EKIVLKENTP GQDLLEWCKE VTKDYPNVKV TNLTTSWRNG MAFCAIIHHF
510 520 530 540 550
VPELIDMSKL SAHDVVGNCR IGFDAAESLG IPRVIEPRDM NMLTVPDKLA
560 570 580 590 600
VMTYLHQLRA HFTGKQLKIE QIGSTADESS YVIGDYKSDN LSQNRINFSH
610 620 630 640 650
PKSLLLHQNS FDEEINGSNK SEQLSPTSKK DVKNLILYNS KNILDKVLSP
660 670 680 690 700
TKDKNSINAS QHANQSPMLS CQTTPPQDES LDKGSQPGGK ENSSITTIDP
710 720 730 740 750
QAASEERQQR LLEQARRLIL ETRVKSGGSI ESPTRPKLER TISPIHNGAE
760 770 780 790 800
EFYAEHAKKL ELKEPGSPSH RLSDPKVLQS FNAIVERVSP KHEKRGDKLS
810 820 830 840 850
YIDSELEALE REQEAIDQKA SNLEAKLRAV MGGNPSNNRR GGARNSNPFL
860 870 880 890 900
RLIRNSIGGG DVIRIKLLDS DDESLFGGGA GSGGGRSGAC SEDDDRDTSS
910 920 930 940 950
DSVCNSGDEL HTRLRPRPRS HSCFVNKNHQ STINTPAHLR PHHVHHVVPY
960 970 980 990 1000
THMLDSSPSA LSSQQSSCDN LPACSDDDEV LAVAANGRAA SLRRQQDRHR
1010 1020 1030 1040 1050
RRRQRRERRS HLCHTPNHCE TEETEEQLLS QWFTLVNKKN ALLRRQMQLN
1060 1070 1080 1090 1100
ILEQEKDLER KYTMLNQELR AAQSVEDWRK TEVQREKERL LLEELMTIVD
1110 1120 1130 1140
KRDQLVQHLH NQEIAIEDDQ EIARKLEHVD ISAEKDKCVL Q
Length:1,141
Mass (Da):127,910
Last modified:March 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i768FAFCE360D6B4D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A1ZAN2A1ZAN2_DROME
Eps15 homology domain containing pr...
Ehbp1 2R11, CG15609-RG, dEHBP-1, dEHBP1, Dmel\CG15609
965Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4UZL2A4UZL2_DROME
Eps15 homology domain containing pr...
Ehbp1 2R11, dEHBP-1, dEHBP1, Dmel\CG15609, EHBP1
987Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7YZI1B7YZI1_DROME
Eps15 homology domain containing pr...
Ehbp1 2R11, dEHBP-1, dEHBP1, Dmel\CG15609, EHBP1
994Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAS64824.2

NCBI Reference Sequences

More...
RefSeqi
NP_995865.2, NM_206143.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0114627; FBpp0113119; FBgn0034180

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36912

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAS64824.2
RefSeqiNP_995865.2, NM_206143.3

3D structure databases

SMRiA4UZL3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0113119

Proteomic databases

PaxDbiA4UZL3
PRIDEiA4UZL3

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
36912

Genome annotation databases

EnsemblMetazoaiFBtr0114627; FBpp0113119; FBgn0034180
GeneIDi36912

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23301
FlyBaseiFBgn0034180, Ehbp1

Phylogenomic databases

eggNOGiKOG0035, Eukaryota
GeneTreeiENSGT00940000170931
HOGENOMiCLU_004178_1_1_1
InParanoidiA4UZL3
OrthoDBi165311at2759
PhylomeDBiA4UZL3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36912, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36912

Gene expression databases

BgeeiFBgn0034180, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues
ExpressionAtlasiA4UZL3, baseline and differential
GenevisibleiA4UZL3, DM

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR019448, NT-C2
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF10358, NT-C2, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS51848, BMERB, 1 hit
PS51840, C2_NT, 1 hit
PS50021, CH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4UZL3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4UZL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 2, 2021
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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