UniProtKB - A4UCS9 (A4UCS9_HUMAN)
Protein
Fructose-bisphosphate aldolase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- β-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphateUniRule annotationARBA annotationEC:4.1.2.13UniRule annotationARBA annotation
: glycolysis Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationARBA annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- Hexokinase (HK3), Hexokinase, Hexokinase-3 (HK3), Hexokinase, Hexokinase-4 (GCK), Hexokinase, Phosphotransferase (GCK), Phosphotransferase (GCK), Phosphotransferase (HK2), Hexokinase (HK2), Phosphotransferase (GCK), Hexokinase, Phosphotransferase (GCK), Phosphotransferase, Hexokinase, Phosphotransferase, Hexokinase HKDC1 (HKDC1), Hexokinase-1 (HK1), Hexokinase-2 (HK2), Hexokinase, Phosphotransferase (HK2), Hexokinase, Hexokinase (HK1), Hexokinase, Phosphotransferase (GCK), Hexokinase, Hexokinase (DKFZp686M1669), Phosphotransferase (HK3)
- Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI)
- ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Liver phosphofructokinase isoform a variant, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), PFKL protein (PFKL), cDNA FLJ30173 fis, clone BRACE2000969, highly similar to 6-phosphofructokinase, liver type, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Phosphofructokinase muscle isoform 4 (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), PFKL protein (PFKL), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Phosphofructokinase muscle isoform 3 (PFKM), cDNA FLJ61026, highly similar to Homo sapiens phosphofructokinase, liver (PFKL), transcript variant 1, mRNA, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase (PFKM), Phosphofructokinase-P (PFK-P), PFKM protein (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Phosphofructokinase muscle isoform 2 (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), cDNA FLJ56281, highly similar to 6-phosphofructokinase, muscle type, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Uncharacterized protein DKFZp686L2097 (DKFZp686L2097), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), Uncharacterized protein DKFZp686G1648 (DKFZp686G1648), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase, liver type (PFKL), Similar to phosphofructokinase, platelet, ATP-dependent 6-phosphofructokinase, platelet type (PFKP), PFKM protein (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), cDNA FLJ40373 fis, clone TESTI2035003, highly similar to 6-phosphofructokinase type C, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), PFKP protein (PFKP)
- Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase (HEL-S-87p), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
GO - Molecular functioni
- fructose-bisphosphate aldolase activity Source: UniProtKB-EC
GO - Biological processi
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | LyaseUniRule annotation |
Biological process | GlycolysisUniRule annotation |
Ligand | Schiff baseARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00183 |
Names & Taxonomyi
Protein namesi | Recommended name: Fructose-bisphosphate aldolaseUniRule annotationARBA annotation (EC:4.1.2.13UniRule annotationARBA annotation) |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR029768, Aldolase_I_AS IPR013785, Aldolase_TIM IPR000741, FBA_I |
Pfami | View protein in Pfam PF00274, Glycolytic, 1 hit |
PROSITEi | View protein in PROSITE PS00158, ALDOLASE_CLASS_I, 1 hit |
i Sequence
Sequence statusi: Fragment.
A4UCS9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
TNGETTTQGL DGLSERCAQY KKDGADFAKW RCVLKIGEHT PSALAIMENA
60 70 80 90 100
NVLARYASIC QQNGIVPIVE PEILPDGDHD LKRCQYVTEK VLAAVYKALS
110 120 130 140
DHHIYLEGTL LKPNMVTPGH ACTQKFSHEE IAMATVTALR R
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 141 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF036496 mRNA Translation: ABO65082.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF036496 mRNA Translation: ABO65082.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A4UCS9 |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00183 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR029768, Aldolase_I_AS IPR013785, Aldolase_TIM IPR000741, FBA_I |
Pfami | View protein in Pfam PF00274, Glycolytic, 1 hit |
PROSITEi | View protein in PROSITE PS00158, ALDOLASE_CLASS_I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A4UCS9_HUMAN | |
Accessioni | A4UCS9Primary (citable) accession number: A4UCS9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 15, 2007 |
Last sequence update: | May 15, 2007 | |
Last modified: | October 7, 2020 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |