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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.UniRule annotation

Activity regulationi

Activated by ATP and maltotriose, which are both required for DNA binding.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8
DNA bindingi856 – 875H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCarbohydrate metabolism, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:YPDSF_0051
OrganismiYersinia pestis (strain Pestoides F)
Taxonomic identifieri386656 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000857861 – 903HTH-type transcriptional regulator MalTAdd BLAST903

Interactioni

Subunit structurei

Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4TGR4
SMRiA4TGR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini832 – 897HTH luxR-typeUniRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the MalT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218261
KOiK03556
OMAiSDWVSNA

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
1.25.40.10, 1 hit
HAMAPiMF_01247 HTH_type_MalT, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR011990 TPR-like_helical_dom_sf
IPR023768 Tscrpt_reg_HTH_MalT
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF48452 SSF48452, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4TGR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLIPSKLSRP VRLQNTVVRD RLLVKLSSAA NYRLTLINCP AGYGKTTLIA
60 70 80 90 100
QWAADQSNLG WYSLDESDNQ SERFATYLIA AIQLATGGHC SKSEALSQKH
110 120 130 140 150
QYANLSALFS QLFIELSNWD GPLYLVIDDY HLITNDAIHE AMRFFLRHQP
160 170 180 190 200
ENLTLIILSR TLPSLGIANL RVRDQLLELG MQQLAFNHHE AQQFFECRLS
210 220 230 240 250
SPLEQGDSSR LCDEVEGWVT ALQLIALSSR QPNSSAQKSA KRLAGLNASH
260 270 280 290 300
LSDYLVDEVL DQVDSKARAF LLRCSVLRSM NDALIVRLTG EDNGQQLLEE
310 320 330 340 350
LERQGLFIHR MDDSAEWFCF HPLFATFLRQ RCQWELALEL PELHHAAAEG
360 370 380 390 400
WMALGYPAEA IHHALAAGDV GMLRDILLQH AWSLFHHSEL ALLEQCLTAL
410 420 430 440 450
PYPLLVQNPE LALLQAWLAQ SQHRYSEVNT LLEQAELAMQ ERKIPVDEIL
460 470 480 490 500
RAEFGALRAQ VAINAGKPDE AEKLATDALK YLPMAHYYSR IVATSVTGEV
510 520 530 540 550
HHCKGELARA LPMMQQTEQM ARRHEAYHYA LWALLQQSEI LIAQGFLQAA
560 570 580 590 600
YETQEKAFEL IREQHLEQLP MHEFLLRIRS QVLWSWSRLD EAEEAARKGV
610 620 630 640 650
EILANYQPQQ QLQCLAMLAK CSLARGDLDN ANVYIQRCEA LQHGSQYHLD
660 670 680 690 700
WITNADKPRV IHWQMTGDKV AAASWLRQTE KPGMADNHFL QGQWRNIARV
710 720 730 740 750
QIILGRFDEA EVVLDELNEN ARRLRLTSDL NRNLLLSNTL YWQTERKGEA
760 770 780 790 800
QKALIESLTL ANRTGFISHF VIEGEAMAQQ LRQLIQLNAL PELEQHRAQR
810 820 830 840 850
ILKDINQHHR HKFAHFDEIF VDKLLTHPQV PELIRTSPLT QREWQVLGLI
860 870 880 890 900
YSGYSNDQIA NELDVAATTI KTHIRNLYQK LGVAHRQEAV QQAQRLLQMM

GYV
Length:903
Mass (Da):103,165
Last modified:May 15, 2007 - v1
Checksum:i728A538719E42251
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000668 Genomic DNA Translation: ABP38477.1
RefSeqiWP_002208926.1, NZ_CP009715.1

Genome annotation databases

EnsemblBacteriaiABP38477; ABP38477; YPDSF_0051
KEGGiypp:YPDSF_0051
PATRICifig|386656.14.peg.519

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000668 Genomic DNA Translation: ABP38477.1
RefSeqiWP_002208926.1, NZ_CP009715.1

3D structure databases

ProteinModelPortaliA4TGR4
SMRiA4TGR4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP38477; ABP38477; YPDSF_0051
KEGGiypp:YPDSF_0051
PATRICifig|386656.14.peg.519

Phylogenomic databases

HOGENOMiHOG000218261
KOiK03556
OMAiSDWVSNA

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
1.25.40.10, 1 hit
HAMAPiMF_01247 HTH_type_MalT, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR011990 TPR-like_helical_dom_sf
IPR023768 Tscrpt_reg_HTH_MalT
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF48452 SSF48452, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMALT_YERPP
AccessioniPrimary (citable) accession number: A4TGR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: October 10, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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