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Protein

Glycerol kinase

Gene

glpK

Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Activity regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15SubstrateUniRule annotation1
Binding sitei19ATPUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Binding sitei267ATPUniRule annotation1
Binding sitei310ATP; via carbonyl oxygenUniRule annotation1
Binding sitei314ATP; via amide nitrogenUniRule annotation1
Binding sitei329ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 17ATPUniRule annotation3
Nucleotide bindingi411 – 415ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00618;UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:ASA_2710
OrganismiAeromonas salmonicida (strain A449)
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000225 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000206941 – 500Glycerol kinaseAdd BLAST500

Proteomic databases

PRIDEiA4SPA7

Interactioni

Protein-protein interaction databases

STRINGi382245.ASA_2710

Structurei

3D structure databases

ProteinModelPortaliA4SPA7
SMRiA4SPA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 86Substrate bindingUniRule annotation2
Regioni245 – 246Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JQ0 Bacteria
COG0554 LUCA
HOGENOMiHOG000222134
KOiK00864
OMAiWQDTRTQ

Family and domain databases

HAMAPiMF_00186 Glycerol_kin, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4SPA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEKKYVVA LDQGTTSSRA IVFDQDANIV GTSQREFTQH YPKAGWVEHD
60 70 80 90 100
PMEIWATQSS VFTEVLAKTG LRSEEIAAIG ITNQRETTVV WEKATGKPIY
110 120 130 140 150
NAIVWQCRRT AAICEELKAR GLEEYVRENT GLVLDAYFSG TKVKWILDNV
160 170 180 190 200
EGAREKAMNG ELLFGTIDTW LVWKMTNGEV HVTDPTNASR TMLYNIRDLK
210 220 230 240 250
WDEKMLDELG IPLSMLPEVK PSSEVYGYTT RGGGSRIPIA GIAGDQQSAL
260 270 280 290 300
FGQLCFEKGM AKNTYGTGCF LLMNTGTEPV RSSNGLLTTV AIGPKGEVNY
310 320 330 340 350
ALEGAVFMGG ATVQWLRDEL KLIHDARDTD YFASKVGDTN GVYLVPAFVG
360 370 380 390 400
LGAPYWDPYA RGTMVGLTRG ANRNHIIRAA LESIAYQSRD VLDAMQQDSG
410 420 430 440 450
IKLAALKVDG GAVANDFLMQ FQSDMMHTPV VRPTRIETTA MGAAFLAGLA
460 470 480 490 500
VGFWKSSDEL EDKFSVDREF IPQMSHEERN KLYHGWQKAV ERSRRWAEED
Length:500
Mass (Da):55,493
Last modified:May 15, 2007 - v1
Checksum:iB08C8EBCDF230D3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA Translation: ABO90729.1
RefSeqiWP_005310059.1, NC_009348.1

Genome annotation databases

EnsemblBacteriaiABO90729; ABO90729; ASA_2710
GeneIDi4995170
KEGGiasa:ASA_2710

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA Translation: ABO90729.1
RefSeqiWP_005310059.1, NC_009348.1

3D structure databases

ProteinModelPortaliA4SPA7
SMRiA4SPA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi382245.ASA_2710

Proteomic databases

PRIDEiA4SPA7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO90729; ABO90729; ASA_2710
GeneIDi4995170
KEGGiasa:ASA_2710

Phylogenomic databases

eggNOGiENOG4108JQ0 Bacteria
COG0554 LUCA
HOGENOMiHOG000222134
KOiK00864
OMAiWQDTRTQ

Enzyme and pathway databases

UniPathwayi
UPA00618;UER00672

Family and domain databases

HAMAPiMF_00186 Glycerol_kin, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLPK_AERS4
AccessioniPrimary (citable) accession number: A4SPA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: October 10, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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