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UniProtKB - A4SK35 (ASTD_AERS4)
Protein
N-succinylglutamate 5-semialdehyde dehydrogenase
Gene
astD
Organism
Aeromonas salmonicida (strain A449)
Status
Functioni
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
UniRule annotationCatalytic activityi
- H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD+ = 2 H+ + N-succinyl-L-glutamate + NADHUniRule annotationEC:1.2.1.71UniRule annotation
: L-arginine degradation via AST pathway Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes L-glutamate and succinate from L-arginine.UniRule annotation This subpathway is part of the pathway L-arginine degradation via AST pathway, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate and succinate from L-arginine, the pathway L-arginine degradation via AST pathway and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 246 | UniRule annotation | 1 | |
Active sitei | 280 | UniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 223 – 228 | NADUniRule annotation | 6 |
GO - Molecular functioni
- succinylglutamate-semialdehyde dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- arginine catabolic process to glutamate Source: UniProtKB-UniRule
- arginine catabolic process to succinate Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Arginine metabolism |
Ligand | NAD |
Enzyme and pathway databases
UniPathwayi | UPA00185;UER00282 |
Names & Taxonomyi
Protein namesi | Recommended name: N-succinylglutamate 5-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.71UniRule annotation)Alternative name(s): Succinylglutamic semialdehyde dehydrogenaseUniRule annotation Short name: SGSDUniRule annotation |
Gene namesi | Name:astDUniRule annotation Ordered Locus Names:ASA_1136 |
Organismi | Aeromonas salmonicida (strain A449) |
Taxonomic identifieri | 382245 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000065746 | 1 – 489 | N-succinylglutamate 5-semialdehyde dehydrogenaseAdd BLAST | 489 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1012, Bacteria |
HOGENOMi | CLU_005391_1_0_6 |
OMAi | NWNKQLT |
OrthoDBi | 744602at2 |
Family and domain databases
CDDi | cd07095, ALDH_SGSD_AstD, 1 hit |
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
HAMAPi | MF_01174, Aldedh_AstD, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR017649, SuccinylGlu_semiald_DH_AstD |
PANTHERi | PTHR11699:SF197, PTHR11699:SF197, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR03240, arg_catab_astD, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
i Sequence
Sequence statusi: Complete.
A4SK35-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHLVQLIDG QWLAGEGKPF ESMDPAKNEV IWQGGAASAS QVDAAVKAAR
60 70 80 90 100
AAFYHWSDLA LEDRLAIVRR YADLLGEHKE ALALTIARET GKPLWETRTE
110 120 130 140 150
VAAMQGKIAI SIRAHDERTG TVENPMPGAK AFVRHKPHGV VAVFGPYNFP
160 170 180 190 200
GHLPNGHIVP ALIAGNTVVF KPSELTPMVA EAMLKIWQEA GLPKGVLNLV
210 220 230 240 250
QGEVETGKAL AGNPDIDGLF FTGSSRTGHF LHQQFAGQPG KILALEMGGN
260 270 280 290 300
NPLIVKDVSD VDGAVHAIVQ SAFITSGQRC TCSRRLFVER GARGDALVKR
310 320 330 340 350
LVEVVGQIKV GLYDAADQPF MGAMISEKAA LGMVAAQANL QQLGGESLLT
360 370 380 390 400
LKHLEAGTGF VSPGIIDVTA IGALPDEEYF GPLLQLIRYD DFDAAIDQGN
410 420 430 440 450
ATSFGLSAGL LGDNEADWQH FFKRIRAGIV NWNKPITGAS SAAPFGGIGA
460 470 480
SGNHRASAYY AADYCAYPVA SVEDSKAAMP DQLSPGLTF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000644 Genomic DNA Translation: ABO89257.1 |
RefSeqi | WP_005317097.1, NC_009348.1 |
Genome annotation databases
EnsemblBacteriai | ABO89257; ABO89257; ASA_1136 |
KEGGi | asa:ASA_1136 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000644 Genomic DNA Translation: ABO89257.1 |
RefSeqi | WP_005317097.1, NC_009348.1 |
3D structure databases
AlphaFoldDBi | A4SK35 |
SMRi | A4SK35 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 382245.ASA_1136 |
Genome annotation databases
EnsemblBacteriai | ABO89257; ABO89257; ASA_1136 |
KEGGi | asa:ASA_1136 |
Phylogenomic databases
eggNOGi | COG1012, Bacteria |
HOGENOMi | CLU_005391_1_0_6 |
OMAi | NWNKQLT |
OrthoDBi | 744602at2 |
Enzyme and pathway databases
UniPathwayi | UPA00185;UER00282 |
Family and domain databases
CDDi | cd07095, ALDH_SGSD_AstD, 1 hit |
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
HAMAPi | MF_01174, Aldedh_AstD, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR017649, SuccinylGlu_semiald_DH_AstD |
PANTHERi | PTHR11699:SF197, PTHR11699:SF197, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR03240, arg_catab_astD, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ASTD_AERS4 | |
Accessioni | A4SK35Primary (citable) accession number: A4SK35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | May 15, 2007 | |
Last modified: | May 25, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families