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Entry version 82 (13 Feb 2019)
Sequence version 1 (15 May 2007)
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Protein
Submitted name:

Isoleucine-tRNA synthetase

Gene

IleS

Organism
Ostreococcus lucimarinus (strain CCE9901)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Isoleucine-tRNA synthetaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IleSImported
ORF Names:OSTLU_119549Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOstreococcus lucimarinus (strain CCE9901)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri436017 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytaprasinophytesMamiellophyceaeMamiellalesBathycoccaceaeOstreococcusunclassified Ostreococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001568 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
436017.A4RSX0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A4RSX0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 649tRNA-synt_1InterPro annotationAdd BLAST629
Domaini705 – 853Anticodon_1InterPro annotationAdd BLAST149

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0434 Eukaryota
COG0060 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246403

KEGG Orthology (KO)

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KOi
K01870

Identification of Orthologs from Complete Genome Data

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OMAi
GYRVMPY

Database of Orthologous Groups

More...
OrthoDBi
59501at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07961 Anticodon_Ia_Ile_ABEc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.620, 1 hit
3.90.740.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR033709 Anticodon_Ile_ABEc
IPR002301 Ile-tRNA-ligase
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00984 TRNASYNTHILE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00392 ileS, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4RSX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLYEVVEGQ QYSFPDEELR ILKLWDDIDA FGEQLRRTEG KPEFVFYDGP
60 70 80 90 100
PFATGLPHYG HLLAGTIKDI VTRFASTTGK HVVRRFGWDC HGLPVEHEID
110 120 130 140 150
KKLKIGGRED VLKMGIGNYN EECRSIVLRY SAEWEKTVKR IGRWIDFEND
160 170 180 190 200
YKTMDPNFME SIWWVFKSLD DKKLIYKGFK VMPYSTACNT PLSNFELGIV
210 220 230 240 250
KSYSAQIAFP VVGCELGASL VAWTTTPWTL PSNTALCVNP ELQYVYLKDP
260 270 280 290 300
EGNVYIVAEA RMESLPHATK KSKGITKVLN DEWCILKSVS GRSLSGLKYK
310 320 330 340 350
PIFDWFEGSL GPKAFTVCCD SYVTDDSGTG VVHQAPAYGE DDYRVCIENN
360 370 380 390 400
VLQKDDALPD PVDANGCFME PAAQPYIGMY IKDADKLLIQ QAKECGRLID
410 420 430 440 450
NARIVHSYPF CWRSRTPLIY RAVASFFVKV EEIKERLVAN NLQTEWVPTY
460 470 480 490 500
VKEKRFHNWL ESAHDWSISR NRYWGTPIPV WSSPSGDETI VVGSIAELEK
510 520 530 540 550
LTGKVVTDLH RHFIDHLEIP SSRGPEFPPL RRVEDVFDCW FESGSMPYAQ
560 570 580 590 600
QHYPFENKER FESAFPADFV AEGLDQTRGW FYTLMVLSTA LFDKPAFKNL
610 620 630 640 650
ICNGLVLASD GKKMSKSLKN YPDPNTILDK YGADALRLYL IDSPVVRAEP
660 670 680 690 700
LRFKEEGVFG VLKDVFLPWY NAYRFLVQNV RLLEETASIP FTPSEGEPTS
710 720 730 740 750
KNVLDIWILS STNSLVQFVT EEMHSYRLYT VVPRLISFIS QLTNVYVRYN
760 770 780 790 800
RGRLKGKDGG DESRCALDVL FNVLLTICKT MAPFTPFFVE NMYQNLRRCL
810 820 830 840 850
PESEESIHLC EFPRFNQSSS PRIESSVSKM QAVIETVRAV RERTGKPLKM
860 870 880 890 900
PLSAITIVDS DTEFLEDSQN ALLSYLRDEL NVRRVEVSSD PAKFATLKAE
910 920 930 940 950
PNFAALGKRV GKSMKEISQE IKSWDPFKIA TFQSGKSTVI AGHELTSSDI
960 970 980 990 1000
IVKYHFNHQE DANVAYATVD DGGMVILDLS VDSSILFSAS ARLLVNRVQK
1010 1020 1030 1040 1050
LRKSAGLRTN DQVQVLYTIT GDGDEEFIHQ MLDSQGDYIS KSLGCIPTIE
1060 1070 1080 1090 1100
KDDGHVVFGR DNFEISSALC MNISVVRPKI KMDSVSVQGS SKVDEIEAIL
1110 1120 1130
SAREYCTVAG ELFRGEMKDI SLNGATVCLS WSDRQC
Length:1,136
Mass (Da):128,647
Last modified:May 15, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69D47892238621E7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000582 Genomic DNA Translation: ABO94713.1

NCBI Reference Sequences

More...
RefSeqi
XP_001416420.1, XM_001416383.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
ABO94713; ABO94713; OSTLU_119549

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5000489

Gramene; a comparative resource for plants

More...
Gramenei
ABO94713; ABO94713; OSTLU_119549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
olu:OSTLU_119549

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000582 Genomic DNA Translation: ABO94713.1
RefSeqiXP_001416420.1, XM_001416383.1

3D structure databases

ProteinModelPortaliA4RSX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436017.A4RSX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiABO94713; ABO94713; OSTLU_119549
GeneIDi5000489
GrameneiABO94713; ABO94713; OSTLU_119549
KEGGiolu:OSTLU_119549

Phylogenomic databases

eggNOGiKOG0434 Eukaryota
COG0060 LUCA
HOGENOMiHOG000246403
KOiK01870
OMAiGYRVMPY
OrthoDBi59501at2759

Family and domain databases

CDDicd07961 Anticodon_Ia_Ile_ABEc, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.740.10, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR033709 Anticodon_Ile_ABEc
IPR002301 Ile-tRNA-ligase
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PRINTSiPR00984 TRNASYNTHILE
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00392 ileS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4RSX0_OSTLU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4RSX0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 13, 2019
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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