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Entry version 67 (12 Aug 2020)
Sequence version 3 (25 Jan 2012)
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Protein

Structure-specific endonuclease subunit SLX4

Gene

SLX4

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA recombination, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structure-specific endonuclease subunit SLX4UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLX4UniRule annotation
ORF Names:MGG_16183
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri242507 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesPyriculariaceaePyricularia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009058 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:MGG_16183

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003880311 – 955Structure-specific endonuclease subunit SLX4Add BLAST955

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in response to DNA damage.UniRule annotation

Keywords - PTMi

Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with SLX1.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A4R1T1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLX4 family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SEB3, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005957_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4R1T1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRRDWTP

Database of Orthologous Groups

More...
OrthoDBi
231792at2759

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03110, Endonuc_su_Slx4, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017956, AT_hook_DNA-bd_motif
IPR000637, HMGI/Y_DNA-bd_CS
IPR027784, Slx4_ascomycetes
IPR018574, Structure-sp_endonuc_su_Slx4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09494, Slx4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00384, AT_hook, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4R1T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTPRFLPSS PPGQARSDLY TTLVSSSPDL PSINELVSRY AKKPKPLRSG
60 70 80 90 100
SNAASIPTTA TTTFTTAAKL LQSAQAEQAD LVETLPPPRA KTKAKPKQKD
110 120 130 140 150
PPEVVDLSPD LPVNIPEPQP ERRKARKTAN GVTKKKRGGG EESVADDATN
160 170 180 190 200
EITTPTKNQP WKFFKSPSPR TTSDLEITGF QEVAATTAPV TTSTTDLTKG
210 220 230 240 250
TASAQNKVTK SRVRKTSSAA SRKKKAETVS RHFAVPDDVS TAPEPITVPD
260 270 280 290 300
DAPEEQLFNL EPAVARRLDW TPPRETNTAD LCPVSSNAKE VTSTLDGALS
310 320 330 340 350
AAPAAVQNVF LTLQDKFAYP VEQVARRPDS PSKELGPPPE VIKKRKVIQL
360 370 380 390 400
VGPSNDSKIP NQASPVKSKA PKKKPRTITD LATAAYTTEG KQSNAPAKKG
410 420 430 440 450
TLTSYLEGQG EQVFQHCHPD SRLRKPERKR KPKGRGQVLL SPLSAIDQSA
460 470 480 490 500
RQDFVFGTSS QLAQEHSPTF LRDLHAALRQ SNDFSDDPFA SPIMAAPQGR
510 520 530 540 550
KLWTAGARGE EGDLMNIEVI DLVDSPAFPD DPDAIVRAEM QKSPSRSEPK
560 570 580 590 600
GIKNRRTPMV NLDSSEIDIS EPHARDLESA NSAEHTLKTQ ASKSTHFAST
610 620 630 640 650
TPPRPTKITM VPACENTAEP PIVASDVDSD NEPPPSNQQA YQMPPPPRPV
660 670 680 690 700
VPEETAIPRP NFEVMTDTQL SKQVSSYGFK SVKKRSAMIA LLNQCWESKA
710 720 730 740 750
GATGAAGQSS AFATTSRTSA PRGPRGKTST AAAAAKSPTK RPVGRPRKNS
760 770 780 790 800
VGASGDVTVV EATTPVKRPR GRPKKNAKAE ASPDMMQNIA ASMPPTVAAA
810 820 830 840 850
VKTPRRRKKA ATQPAVEILD SDGEAGLSPS PSLSPEPVFS SPEKDSVDVS
860 870 880 890 900
IGEHTTMSLA VTPTAQQAEL FTRITRAVKS APRSTDPDKP SWHEKMLMYD
910 920 930 940 950
PIVLEDLAAW LNSGQLDRVG YDGEVAPADV KMWCESKSIC CLWRMSYRGR

ERKRL
Length:955
Mass (Da):103,087
Last modified:January 25, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C70080930047681
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM001231 Genomic DNA Translation: EHA56942.1

NCBI Reference Sequences

More...
RefSeqi
XP_003709554.1, XM_003709506.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
MGG_16183T0; MGG_16183T0; MGG_16183

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12984549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mgr:MGG_16183

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001231 Genomic DNA Translation: EHA56942.1
RefSeqiXP_003709554.1, XM_003709506.1

3D structure databases

SMRiA4R1T1
ModBaseiSearch...

Genome annotation databases

EnsemblFungiiMGG_16183T0; MGG_16183T0; MGG_16183
GeneIDi12984549
KEGGimgr:MGG_16183

Organism-specific databases

EuPathDBiFungiDB:MGG_16183

Phylogenomic databases

eggNOGiENOG502SEB3, Eukaryota
HOGENOMiCLU_005957_0_0_1
InParanoidiA4R1T1
OMAiRRRDWTP
OrthoDBi231792at2759

Family and domain databases

HAMAPiMF_03110, Endonuc_su_Slx4, 1 hit
InterProiView protein in InterPro
IPR017956, AT_hook_DNA-bd_motif
IPR000637, HMGI/Y_DNA-bd_CS
IPR027784, Slx4_ascomycetes
IPR018574, Structure-sp_endonuc_su_Slx4
PfamiView protein in Pfam
PF09494, Slx4, 1 hit
SMARTiView protein in SMART
SM00384, AT_hook, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLX4_MAGO7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4R1T1
Secondary accession number(s): G4MMG4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 25, 2012
Last modified: August 12, 2020
This is version 67 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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