UniProtKB - A4QVZ8 (NTE1_MAGO7)
Protein
Lysophospholipase NTE1
Gene
NTE1
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Functioni
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity
Catalytic activityi
- EC:3.1.1.5
Activity regulationi
Inhibited by organophosphorus esters.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1233 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 1351 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 658 – 777 | cNMP 1Add BLAST | 120 | |
Nucleotide bindingi | 821 – 941 | cNMP 2Add BLAST | 121 |
GO - Molecular functioni
- lysophospholipase activity Source: UniProtKB-EC
- phosphatidyl phospholipase B activity Source: UniProtKB-EC
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
- phosphatidylcholine metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophospholipase NTE1 (EC:3.1.1.5)Alternative name(s): Intracellular phospholipase B Neuropathy target esterase homolog |
Gene namesi | Name:NTE1 ORF Names:MGG_06143 |
Organismi | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) |
Taxonomic identifieri | 242507 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Magnaporthales › Pyriculariaceae › Pyricularia › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:MGG_06143 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | CytoplasmicBy similarityAdd BLAST | 25 | |
Transmembranei | 26 – 46 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 71 | LumenalBy similarityAdd BLAST | 25 | |
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 93 – 1503 | CytoplasmicBy similarityAdd BLAST | 1411 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295324 | 1 – 1503 | Lysophospholipase NTE1Add BLAST | 1503 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1200 – 1364 | PNPLAPROSITE-ProRule annotationAdd BLAST | 165 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1204 – 1209 | GXGXXGPROSITE-ProRule annotation | 6 | |
Motifi | 1231 – 1235 | GXSXGPROSITE-ProRule annotation | 5 | |
Motifi | 1351 – 1353 | DGA/GPROSITE-ProRule annotation | 3 |
Sequence similaritiesi
Belongs to the NTE family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2968, Eukaryota |
HOGENOMi | CLU_000960_1_1_1 |
InParanoidi | A4QVZ8 |
OMAi | YPKATAH |
OrthoDBi | 253518at2759 |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 2 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
i Sequence
Sequence statusi: Complete.
A4QVZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSSTAALAT ASAKLDAVAQ QGSSSWIGFF ANIILGIISL VYSILYSVLK
60 70 80 90 100
LTTFSIPSLL YTLFSTSLTV TMNATTLMLI IVLVFSLVSW FVRYRYLNMY
110 120 130 140 150
SRLPPEPQRK EPDVDLFPDT HPGGSKPGLS NYLDEFLSAI KIFGYLERPV
160 170 180 190 200
FHELTRSMQT RKLIAGETFN LEEEKGFCMV VDGLVEIFVK SARTGQHPVG
210 220 230 240 250
ESCSIDSDGS DEHEEYQAGN QRYQLLTEVH NGAPMSSLFS IMSLFTEDIK
260 270 280 290 300
LRHGGDEGGE PTSATETYTS SRYGLGNDFS DQRESTVSVP TTPQLERSSS
310 320 330 340 350
HGPTLHDGDA NPSMGGRVPA SIPPMSLDPP LQSRPKRPTT SRHATTSVHP
360 370 380 390 400
DIIARATVDT TIAIIPASAF RRLIQIYPKY TAHIVHVILS RFQRVTLATA
410 420 430 440 450
YNYLGLTSEV LHIEKSMIDN ATCQLPNFLR GDALTRLKEK FNHERERIGE
460 470 480 490 500
KDCTKGIALH NSSTGRRRKS TASLRKEAAL QAITHGQRPS SVTASPPLQP
510 520 530 540 550
RESGNKHTSN SGDLLMNIQL SRNGGRRSTS NMDPLTRQST LLGSLETEVV
560 570 580 590 600
SPLSQRTSNP FETRRHAHIS LNKRETRDED GLFRESILEC MFKAIGLTAN
610 620 630 640 650
GTGAREPDSA DASPRLTSYD QIRRGGYSSH NAFGFIDPYG GSVDGDADSI
660 670 680 690 700
TSGGTGPGLP VNPHALAHDM RDEVEIVFFP SGSVLVEQGE RNPGLYYVVD
710 720 730 740 750
GFLDVCMSAA DESSGDILKA SKNESSLNIG PGNQQGSAGR DRFMDANLGQ
760 770 780 790 800
SSSRKRASNV RRNVALIKPG GLAGYVGSIS SHRSFIDVVA KTDVYVGFLP
810 820 830 840 850
RQSLERIVDR YPIVLLTMAK RLTNLLPKLI LHIDFALEWL QVNAGEVIFH
860 870 880 890 900
GGEESEAIYI VLNGRLRLVE DRQEGGVDVR GEFGQGESIG ELEVLTESAR
910 920 930 940 950
SGTLHAIRNT ELVKFPRTLF NSLAQEHPNI TIKISKIIAS RMRKVVDDPS
960 970 980 990 1000
TFVGKEGALK ASLNKSSSTL NLRTVAILPV TSGVPVVEFG NRLMGALTQV
1010 1020 1030 1040 1050
GTPNGATSLS QSAILNHLGR HAFNKMGKLK LSQYLADLEE KYGLVMYVAD
1060 1070 1080 1090 1100
TNVNSPWTQT CITQADCILL VGLAEGSPEI GEYERFMLGM KSTARKVLVL
1110 1120 1130 1140 1150
LHADRYAEPG LTRSWLRNRM WINGGHHHVQ MAFRTQSVPI NPTAKRTGPS
1160 1170 1180 1190 1200
LKERVQILQA EIQKYTSRKV RHSPFYSPDA PFKGDFHRLA RRLCGKSVGL
1210 1220 1230 1240 1250
VLGGGGARGL AHIGIIRAME ESGIPIDIVG GTSIGSFVGA LYARHADVVP
1260 1270 1280 1290 1300
IFGLSKKFAG RMASVWRFAL DLTYPSASYT TGHEFNRGIF KTFGKAQIED
1310 1320 1330 1340 1350
FWLEFYCNTT NISKSRQEIH TSGYAWRYVR ASMSLAGLLP PLCDEGSMLL
1360 1370 1380 1390 1400
DGGYIDNLTV SHMKSLGVDI IFAVDVGSLD DDVPQAYGDT LSGLWAFVNR
1410 1420 1430 1440 1450
WNPLSSTPNP PTLAEIQARL AYVSSVDALE RAKMTPGCVY MRPPIDEYGT
1460 1470 1480 1490 1500
LEFGRFDEIV QVGYKYGLEF LQKLRDEGAL PVVEETEAKK ALRRTMAPRR
ASI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM001233 Genomic DNA Translation: EHA52211.1 |
RefSeqi | XP_003712018.1, XM_003711970.1 |
Genome annotation databases
EnsemblFungii | MGG_06143T0; MGG_06143T0; MGG_06143 |
GeneIDi | 2684255 |
KEGGi | mgr:MGG_06143 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM001233 Genomic DNA Translation: EHA52211.1 |
RefSeqi | XP_003712018.1, XM_003711970.1 |
3D structure databases
SMRi | A4QVZ8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 318829.MGG_06143T0 |
Genome annotation databases
EnsemblFungii | MGG_06143T0; MGG_06143T0; MGG_06143 |
GeneIDi | 2684255 |
KEGGi | mgr:MGG_06143 |
Organism-specific databases
VEuPathDBi | FungiDB:MGG_06143 |
Phylogenomic databases
eggNOGi | KOG2968, Eukaryota |
HOGENOMi | CLU_000960_1_1_1 |
InParanoidi | A4QVZ8 |
OMAi | YPKATAH |
OrthoDBi | 253518at2759 |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 2 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTE1_MAGO7 | |
Accessioni | A4QVZ8Primary (citable) accession number: A4QVZ8 Secondary accession number(s): G4N5L8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 10, 2021 | |
This is version 87 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families