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Entry version 94 (08 May 2019)
Sequence version 2 (10 Jul 2007)
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Protein

Low-density lipoprotein receptor-related protein 5-like protein

Gene

LRP5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Wnt-activated receptor activity Source: GO_Central
  • Wnt-protein binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 5-like protein
Short name:
LRP-5-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRP5L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25323 LRP5L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A4QPB2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000100068

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671533

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRP5L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002944741 – 252Low-density lipoprotein receptor-related protein 5-like proteinAdd BLAST252

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A4QPB2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A4QPB2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A4QPB2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A4QPB2

PRoteomics IDEntifications database

More...
PRIDEi
A4QPB2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
689
690 [A4QPB2-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100068 Expressed in 127 organ(s), highest expression level in right lobe of thyroid gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A4QPB2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028717

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124819, 2 interactors

Protein interaction database and analysis system

More...
IntActi
A4QPB2, 2 interactors

Molecular INTeraction database

More...
MINTi
A4QPB2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000482378

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati3 – 45LDL-receptor class B 1Add BLAST43
Repeati46 – 88LDL-receptor class B 2Add BLAST43
Repeati89 – 132LDL-receptor class B 3Add BLAST44
Repeati133 – 175LDL-receptor class B 4Add BLAST43
Repeati176 – 218LDL-receptor class B 5Add BLAST43

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1215 Eukaryota
ENOG410XP34 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156574

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113388

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4QPB2

Identification of Orthologs from Complete Genome Data

More...
OMAi
WIDWGEN

Database of Orthologous Groups

More...
OrthoDBi
121310at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A4QPB2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000033 LDLR_classB_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00058 Ldl_recept_b, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00135 LY, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51120 LDLRB, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A4QPB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGHVYWTDD EVWAIRRAYL DGSGAQTLIN TKINDPDDIA VNWVARSLYW
60 70 80 90 100
THTGTEHIEV TCLNSTSHKI LVSEDMDEPR AIALHPEMGL TYWIDWGENP
110 120 130 140 150
EIKRANLDRQ ELRVLVNASL GWPNGLALDL QEGKLYWGDA KTDKIEAISV
160 170 180 190 200
DETKRQTLLK DKLPHIFRFT LLGDFIYWTA WQHHSIKRVH KVKANRDVII
210 220 230 240 250
DQLPDLMGLK AVNVDKVVGT NPHADRNGGA ATCASSRPTQ PGLAAPSRAW

NC
Length:252
Mass (Da):28,483
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20ACE726A1FF7C5A
GO
Isoform 2 (identifier: A4QPB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-224: TNPHA → PGTAE
     225-252: Missing.

Note: No experimental confirmation available.
Show »
Length:224
Mass (Da):25,620
Checksum:i5CFCFB99517D359A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03319161T → M. Corresponds to variant dbSNP:rs17616994Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026667220 – 224TNPHA → PGTAE in isoform 2. 1 Publication5
Alternative sequenceiVSP_026668225 – 252Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL137651 mRNA No translation available.
AL022324 Genomic DNA No translation available.
BC137460 mRNA Translation: AAI37461.1
BC137463 mRNA Translation: AAI37464.1
BC139736 mRNA Translation: AAI39737.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33626.1 [A4QPB2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001129244.1, NM_001135772.1 [A4QPB2-1]
NP_872298.1, NM_182492.2 [A4QPB2-1]
XP_006724435.1, XM_006724372.3 [A4QPB2-2]
XP_016884572.1, XM_017029083.1 [A4QPB2-1]
XP_016884573.1, XM_017029084.1 [A4QPB2-1]
XP_016884574.1, XM_017029085.1 [A4QPB2-1]
XP_016884575.1, XM_017029086.1 [A4QPB2-1]
XP_016884576.1, XM_017029087.1 [A4QPB2-1]
XP_016884577.1, XM_017029088.1 [A4QPB2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000402859; ENSP00000384291; ENSG00000100068 [A4QPB2-1]
ENST00000610821; ENSP00000482378; ENSG00000100068 [A4QPB2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
91355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:91355

UCSC genome browser

More...
UCSCi
uc010guw.2 human [A4QPB2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137651 mRNA No translation available.
AL022324 Genomic DNA No translation available.
BC137460 mRNA Translation: AAI37461.1
BC137463 mRNA Translation: AAI37464.1
BC139736 mRNA Translation: AAI39737.1
CCDSiCCDS33626.1 [A4QPB2-1]
RefSeqiNP_001129244.1, NM_001135772.1 [A4QPB2-1]
NP_872298.1, NM_182492.2 [A4QPB2-1]
XP_006724435.1, XM_006724372.3 [A4QPB2-2]
XP_016884572.1, XM_017029083.1 [A4QPB2-1]
XP_016884573.1, XM_017029084.1 [A4QPB2-1]
XP_016884574.1, XM_017029085.1 [A4QPB2-1]
XP_016884575.1, XM_017029086.1 [A4QPB2-1]
XP_016884576.1, XM_017029087.1 [A4QPB2-1]
XP_016884577.1, XM_017029088.1 [A4QPB2-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124819, 2 interactors
IntActiA4QPB2, 2 interactors
MINTiA4QPB2
STRINGi9606.ENSP00000482378

Polymorphism and mutation databases

BioMutaiLRP5L

Proteomic databases

EPDiA4QPB2
jPOSTiA4QPB2
MaxQBiA4QPB2
PaxDbiA4QPB2
PRIDEiA4QPB2
ProteomicsDBi689
690 [A4QPB2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402859; ENSP00000384291; ENSG00000100068 [A4QPB2-1]
ENST00000610821; ENSP00000482378; ENSG00000100068 [A4QPB2-1]
GeneIDi91355
KEGGihsa:91355
UCSCiuc010guw.2 human [A4QPB2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91355

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRP5L
HGNCiHGNC:25323 LRP5L
HPAiHPA028717
neXtProtiNX_A4QPB2
OpenTargetsiENSG00000100068
PharmGKBiPA142671533

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1215 Eukaryota
ENOG410XP34 LUCA
GeneTreeiENSGT00940000156574
HOGENOMiHOG000113388
InParanoidiA4QPB2
OMAiWIDWGEN
OrthoDBi121310at2759
PhylomeDBiA4QPB2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRP5L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
91355

Protein Ontology

More...
PROi
PR:A4QPB2

Gene expression databases

BgeeiENSG00000100068 Expressed in 127 organ(s), highest expression level in right lobe of thyroid gland
GenevisibleiA4QPB2 HS

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000033 LDLR_classB_rpt
PfamiView protein in Pfam
PF00058 Ldl_recept_b, 2 hits
SMARTiView protein in SMART
SM00135 LY, 4 hits
PROSITEiView protein in PROSITE
PS51120 LDLRB, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRP5L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4QPB2
Secondary accession number(s): B0QYF3, B0QYF4, B2RPI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 8, 2019
This is version 94 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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