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UniProtKB - A4QPA9 (A4QPA9_HUMAN)
Protein
Submitted name:
Mitogen-activated protein kinase kinase 1
Gene
MAP2K1
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 97 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- MAP kinase kinase activity Source: Ensembl
- protein serine/threonine kinase activity Source: UniProtKB-KW
GO - Biological processi
- Bergmann glial cell differentiation Source: Ensembl
- cell motility Source: Ensembl
- cerebellar cortex formation Source: Ensembl
- epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
- ERK1 and ERK2 cascade Source: Ensembl
- face development Source: Ensembl
- heart development Source: Ensembl
- keratinocyte differentiation Source: Ensembl
- labyrinthine layer development Source: Ensembl
- neuron differentiation Source: Ensembl
- placenta blood vessel development Source: Ensembl
- positive regulation of axonogenesis Source: Ensembl
- positive regulation of MAPK cascade Source: Ensembl
- regulation of axon regeneration Source: Ensembl
- thymus development Source: Ensembl
- thyroid gland development Source: Ensembl
- trachea formation Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Mitogen-activated protein kinase kinase 1ImportedSubmitted name: Mitogen-activated protein kinase kinase 1, isoform CRA_aImportedSubmitted name: cDNA FLJ76051, highly similar to Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNAImported |
Gene namesi | Name:MAP2K1Imported ORF Names:hCG_24510Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000169032 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169032, Expressed in secondary oocyte and 246 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 361 | Protein kinaseInterPro annotationAdd BLAST | 294 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
OMAi | EAWASTF |
OrthoDBi | 688282at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A4QPA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL
60 70 80 90 100
EAFLTQKQKV GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH
110 120 130 140 150
LEIKPAIRNQ IIRELQVLHE CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS
160 170 180 190 200
LDQVLKKAGR IPEQILGKVS IAVIKGLTYL REKHKIMHRD VKPSNILVNS
210 220 230 240 250
RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY SVQSDIWSMG
260 270 280 290 300
LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY
310 320 330 340 350
GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA
360 370 380 390
DLKQLMVHAF IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC137459 mRNA Translation: AAI37460.1 BC139729 mRNA Translation: AAI39730.1 AK291500 mRNA Translation: BAF84189.1 CH471082 Genomic DNA Translation: EAW77765.1 |
RefSeqi | NP_002746.1, NM_002755.3 |
Genome annotation databases
GeneIDi | 5604 |
KEGGi | hsa:5604 |
MANE-Selecti | ENST00000307102.10; ENSP00000302486.5; NM_002755.4; NP_002746.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC137459 mRNA Translation: AAI37460.1 BC139729 mRNA Translation: AAI39730.1 AK291500 mRNA Translation: BAF84189.1 CH471082 Genomic DNA Translation: EAW77765.1 |
RefSeqi | NP_002746.1, NM_002755.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3542, 3357 antibodies from 51 providers |
DNASUi | 5604 |
Genome annotation databases
GeneIDi | 5604 |
KEGGi | hsa:5604 |
MANE-Selecti | ENST00000307102.10; ENSP00000302486.5; NM_002755.4; NP_002746.1 |
Organism-specific databases
CTDi | 5604 |
PharmGKBi | PA30584 |
VEuPathDBi | HostDB:ENSG00000169032 |
Phylogenomic databases
OMAi | EAWASTF |
OrthoDBi | 688282at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5604, 29 hits in 1085 CRISPR screens |
ChiTaRSi | MAP2K1, human |
GenomeRNAii | 5604 |
Gene expression databases
Bgeei | ENSG00000169032, Expressed in secondary oocyte and 246 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A4QPA9_HUMAN | |
Accessioni | A4QPA9Primary (citable) accession number: A4QPA9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 15, 2007 |
Last sequence update: | May 15, 2007 | |
Last modified: | January 19, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |