MAP2K1

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
MAP kinase kinase activity Source: Ensembl
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

Bergmann glial cell differentiation Source: Ensembl
cell motility Source: Ensembl
cerebellar cortex formation Source: Ensembl
epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
ERK1 and ERK2 cascade Source: Ensembl
face development Source: Ensembl
heart development Source: Ensembl
keratinocyte differentiation Source: Ensembl
labyrinthine layer development Source: Ensembl
neuron differentiation Source: Ensembl
placenta blood vessel development Source: Ensembl
positive regulation of axonogenesis Source: Ensembl
regulation of axon regeneration Source: Ensembl
thymus development Source: Ensembl
thyroid gland development Source: Ensembl
trachea formation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Mitogen-activated protein kinase kinase 1Imported Submitted name: Mitogen-activated protein kinase kinase 1, isoform CRA_aImported Submitted name: cDNA FLJ76051, highly similar to Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNAImported
Gene namesⁱ	Name:MAP2K1Imported ORF Names:hCG_24510Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169032.9

EuPathDBⁱ

HostDB:ENSG00000169032.9

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA30584

PharmGKBⁱ

PA30584

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000169032 Expressed in 235 organ(s), highest expression level in secondary oocyte

Bgeeⁱ

ENSG00000169032 Expressed in 235 organ(s), highest expression level in secondary oocyte

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	68 – 361	Protein kinaseInterPro annotationAdd BLAST		294

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	23 – 50	Sequence analysisAdd BLAST		28

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.UniRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0581 Eukaryota ENOG410XQ5A LUCA
HOVERGENⁱ	HBG108518
KEGG Orthology (KO) More...KOⁱ	K04368
OMAⁱ	ELMFGCP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DEC

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A4QPA9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL 
        60         70         80         90        100
EAFLTQKQKV GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH 
       110        120        130        140        150
LEIKPAIRNQ IIRELQVLHE CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS 
       160        170        180        190        200
LDQVLKKAGR IPEQILGKVS IAVIKGLTYL REKHKIMHRD VKPSNILVNS 
       210        220        230        240        250
RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY SVQSDIWSMG 
       260        270        280        290        300
LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY 
       310        320        330        340        350
GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA 
       360        370        380        390 
DLKQLMVHAF IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV

Length:393

Mass (Da):43,439

Last modified:May 15, 2007 - v1

Checksum:ⁱ0344118FFC842D51

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC137459 mRNA Translation: AAI37460.1 BC139729 mRNA Translation: AAI39730.1 AK291500 mRNA Translation: BAF84189.1 CH471082 Genomic DNA Translation: EAW77765.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002746.1, NM_002755.3
UniGeneⁱ	Hs.145442 Hs.677223

Genome annotation databases

GeneIDⁱ	5604
KEGGⁱ	hsa:5604

Protein	Similar proteins		Species	Score	Length	Source
A4QPA9	Dual specificity mitogen-activated protein kinase kinase 1	)	HUMAN		393	UniRef100_Q02750
Dual specificity mitogen-activated protein kinase kinase 1		CALJA		393
Dual-specificity mitogen-activated protein kinase kinase 1		PANTR		393
MAP2K1 protein		BOVIN		393
Mitogen-activated protein kinase kinase 1		SAIBB		393
+6

Protein	Similar proteins		Species	Score	Length	Source
A4QPA9	Dual specificity mitogen-activated protein kinase kinase 1	)	HUMAN		393	UniRef90_Q02750
Dual specificity mitogen-activated protein kinase kinase 1	)	RABIT		393
Dual specificity mitogen-activated protein kinase kinase 1		RAT		393
Dual specificity mitogen-activated protein kinase kinase 1		PANTR		393
Dual specificity mitogen-activated protein kinase kinase 1		MOUSE		393
+157

Protein	Similar proteins		Species	Score	Length	Source
A4QPA9	Dual specificity mitogen-activated protein kinase kinase 1	)	HUMAN		393	UniRef50_Q02750
Dual specificity mitogen-activated protein kinase kinase 1	)	RABIT		393
Dual specificity mitogen-activated protein kinase kinase 1		RAT		393
Dual specificity mitogen-activated protein kinase kinase 1		MOUSE		393
Dual specificity mitogen-activated protein kinase kinase 1		PANTR		393
+265

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC137459 mRNA Translation: AAI37460.1 BC139729 mRNA Translation: AAI39730.1 AK291500 mRNA Translation: BAF84189.1 CH471082 Genomic DNA Translation: EAW77765.1
RefSeqⁱ	NP_002746.1, NM_002755.3
UniGeneⁱ	Hs.145442 Hs.677223

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5604
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	5604
KEGGⁱ	hsa:5604

Organism-specific databases

CTDⁱ	5604
EuPathDBⁱ	HostDB:ENSG00000169032.9
PharmGKBⁱ	PA30584

Phylogenomic databases

eggNOGⁱ	KOG0581 Eukaryota ENOG410XQ5A LUCA
HOVERGENⁱ	HBG108518
KOⁱ	K04368
OMAⁱ	ELMFGCP
OrthoDBⁱ	EOG091G0DEC

Miscellaneous databases

ChiTaRSⁱ	MAP2K1 human
GenomeRNAiⁱ	5604

Gene expression databases

Bgeeⁱ	ENSG00000169032 Expressed in 235 organ(s), highest expression level in secondary oocyte

Bgeeⁱ

ENSG00000169032 Expressed in 235 organ(s), highest expression level in secondary oocyte

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A4QPA9_HUMAN
Accessionⁱ	A4QPA9Primary (citable) accession number: A4QPA9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 15, 2007
	Last sequence update:	May 15, 2007
	Last modified:	October 10, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A4QPA9 (A4QPA9_HUMAN)

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Mitogen-activated protein kinase kinase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ