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Entry version 83 (16 Jan 2019)
Sequence version 1 (15 May 2007)
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Protein
Submitted name:

Zgc:162198 protein

Gene

zc3h7ba

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri449 – 472C3H1-typePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri581 – 603C3H1-typePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri745 – 773C3H1-typePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri885 – 906C3H1-typePROSITE-ProRule annotationAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zgc:162198 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:zc3h7baImported
ORF Names:zgc:162198Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-4512 zc3h7ba

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A4QNW1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini85 – 152TPR_REGIONInterPro annotationAdd BLAST68
Domaini449 – 472C3H1-typeInterPro annotationAdd BLAST24
Domaini581 – 603C3H1-typeInterPro annotationAdd BLAST23
Domaini745 – 773C3H1-typeInterPro annotationAdd BLAST29
Domaini885 – 906C3H1-typeInterPro annotationAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili908 – 928Sequence analysisAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri449 – 472C3H1-typePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri581 – 603C3H1-typePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri745 – 773C3H1-typePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri885 – 906C3H1-typePROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008703

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058699

Database of Orthologous Groups

More...
OrthoDBi
369231at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A4QNW1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039691 ZC3H7A/B
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14928 PTHR14928, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit
PF00642 zf-CCCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF57667 SSF57667, 1 hit
SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50293 TPR_REGION, 1 hit
PS50103 ZF_C3H1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4QNW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAERQKRQE KIRRALSFIK SSLPYPDPQG YEGFVVQLVC DLLEEGNAVF
60 70 80 90 100
AERDWMRALQ HFSEAISVAL YAENEELSVP SGLLESLYIN RAVVHQNMGE
110 120 130 140 150
FECAVKDCDR VLVICKDSAK ALYRKAVCLK ESGKLREALD CSTACLQASP
160 170 180 190 200
QSVSSLSQEI AECLGLTHRK ASSSSQRNKA AGPEDECTAP SPSDEVSPAS
210 220 230 240 250
QQEKVSDSAD DEWTSPVSPV SVSNSHDAPL CMSGGVPQPL EDLELMGDEL
260 270 280 290 300
DLLLDCMTND KDNTQTRVVP AGLACFSSSS PGLPPAFFSS AGSELNALDS
310 320 330 340 350
FISPEPDSCS ADLDALDSIC PSVGSGSVQL GGEGLDSLSH FSLSDVKACR
360 370 380 390 400
SFLPSVKLTH SPQTRNGHVT STLSSLSKNP LEPTHEFSQA CSACFTSTGP
410 420 430 440 450
GVLDFEFRSD VSHSCNKDLL LCRRRGGANS PWRRIRPRPR NNFQGAFMLC
460 470 480 490 500
REVLETRTCK YGEDCTFAYC PEEIEVWTQE RRGLLIRELL FNPLPTNQKR
510 520 530 540 550
ALSVVELLKM HTGMFMFLCE ACFDCKPRII SKRWKENPTL CANLKPQHQF
560 570 580 590 600
DKKKCLVHAL KGSSVSYSKI RTLNSRCVFD VCRQELSLAC RKESGCIFAH
610 620 630 640 650
SLMELQIWIL QRETGISLDE IVQESIKHWN KQRPAVVASN SPNKTTTAAK
660 670 680 690 700
SMSPIRVQET NGKARPAQET GSAEVKRHRL ELMLKFVCAQ CWKDGLLSEP
710 720 730 740 750
DRALKYCTAK VRHSWTKERR VLLVKSHERK KWVSVRPLPF AKTYPQQYDI
760 770 780 790 800
CAHVLKQRKC HYMGNCSFAH SQEEKDLWTY MKNNSLSDVQ ELFEVWLSTS
810 820 830 840 850
NQGRASDNTS PPQPIEEKQI TMPTDFAESM MEGFYCPLCG KHSNSERQWQ
860 870 880 890 900
RHISSEKHKQ RVFSGEGEDE SLAWTHRFPG RCFSICPRLD GGCPEGVSCD
910 920 930 940 950
FAHSEEELQE WCERRAFLRR RLNKARADML ISPTDNDFGN YNFLLQDETH

TC
Length:952
Mass (Da):106,847
Last modified:May 15, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97DE14D48BCB0910
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC139543 mRNA Translation: AAI39544.1

NCBI Reference Sequences

More...
RefSeqi
NP_001082801.1, NM_001089332.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.66850

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100003994

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:100003994

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139543 mRNA Translation: AAI39544.1
RefSeqiNP_001082801.1, NM_001089332.1
UniGeneiDr.66850

3D structure databases

ProteinModelPortaliA4QNW1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100003994
KEGGidre:100003994

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100003994
ZFINiZDB-GENE-030131-4512 zc3h7ba

Phylogenomic databases

HOGENOMiHOG000008703
HOVERGENiHBG058699
OrthoDBi369231at2759
PhylomeDBiA4QNW1

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039691 ZC3H7A/B
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PANTHERiPTHR14928 PTHR14928, 1 hit
PfamiView protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF57667 SSF57667, 1 hit
SSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit
PS50103 ZF_C3H1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4QNW1_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4QNW1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 16, 2019
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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