UniProtKB - A4QNK9 (A4QNK9_XENTR)
Protein
Tubulin-specific chaperone A
Gene
tbca
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Tubulin-folding protein; involved in the early step of the tubulin folding pathway.ARBA annotation
GO - Molecular functioni
- beta-tubulin binding Source: InterPro
GO - Biological processi
- post-chaperonin tubulin folding pathway Source: UniProtKB-UniRule
- tubulin complex assembly Source: UniProtKB-UniRule
Keywordsi
Molecular function | ChaperoneUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin-specific chaperone AUniRule annotation |
Gene namesi | Name:tbcaImported |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Organism-specific databases
Xenbasei | XB-GENE-490490, tbca |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotation
Cytoskeleton
- microtubule Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotation, MicrotubuleUniRule annotationARBA annotationInteractioni
Subunit structurei
Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
UniRule annotationGO - Molecular functioni
- beta-tubulin binding Source: InterPro
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 108 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 16 – 43 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OrthoDBi | 1471374at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004226, TBCA IPR036126, TBCA_sf |
PANTHERi | PTHR21500, PTHR21500, 1 hit |
Pfami | View protein in Pfam PF02970, TBCA, 1 hit |
SUPFAMi | SSF46988, SSF46988, 1 hit |
i Sequence
Sequence statusi: Complete.
A4QNK9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADPRLRQIK IKTGVVKRLA KEKIMYEKEA KQQEEKIEQM KSEGGDEYII
60 70 80 90 100
KKQTEILQES RMMIPDCHRR LEAAYADLTQ LLENEKELEE KEEYKDARSM
LDSVKLEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC135822 mRNA Translation: AAI35823.1 |
RefSeqi | NP_001163966.1, NM_001170495.1 |
Genome annotation databases
GeneIDi | 100038159 |
KEGGi | xtr:100038159 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC135822 mRNA Translation: AAI35823.1 |
RefSeqi | NP_001163966.1, NM_001170495.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 100038159 |
KEGGi | xtr:100038159 |
Organism-specific databases
CTDi | 6902 |
Xenbasei | XB-GENE-490490, tbca |
Phylogenomic databases
OrthoDBi | 1471374at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004226, TBCA IPR036126, TBCA_sf |
PANTHERi | PTHR21500, PTHR21500, 1 hit |
Pfami | View protein in Pfam PF02970, TBCA, 1 hit |
SUPFAMi | SSF46988, SSF46988, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A4QNK9_XENTR | |
Accessioni | A4QNK9Primary (citable) accession number: A4QNK9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 15, 2007 |
Last sequence update: | May 15, 2007 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |