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Entry version 85 (08 May 2019)
Sequence version 1 (15 May 2007)
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Protein

Tubulin polyglutamylase TTLL7

Gene

Ttll7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyglutamylase which preferentially modifies beta-tubulin (PubMed:16901895, PubMed:17499049, PubMed:19152315). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:16901895, PubMed:19152315). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (PubMed:16901895).3 Publications

Caution

Was initially though to be involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (PubMed:17499049). However, it was later shown to be involved in both steps (PubMed:19152315).2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=20.2 µM for Glu (with 17 µM of tubulin for adult mouse)1 Publication
  2. KM=19.1 µM for ATP (with 17 µM of tubulin for adult mouse)1 Publication
  3. KM=19.6 µM for Glu (with 17 µM of tubulin for newborn mouse)1 Publication
  4. KM=26.5 µM for ATP (with 17 µM of tubulin for newborn mouse)1 Publication
  5. KM=5.4 µM for Glu (with 50 µM of ATP for adult mouse)1 Publication
  6. KM=21.8 µM for tubulin (with 50 µM of ATP for adult mouse)1 Publication
  7. KM=4.4 µM for Glu (with 50 µM of ATP for newborn mouse)1 Publication
  8. KM=15.8 µM for tubulin (with 50 µM of ATP for newborn mouse)1 Publication
  9. KM=7.5 µM for ATP (with 6 µM of Glu for adult mouse)1 Publication
  10. KM=3.1 µM for tubulin (with 6 µM of Glu for adult mouse)1 Publication
  11. KM=16 µM for ATP (with 6 µM of Glu for newborn mouse)1 Publication
  12. KM=6.7 µM for tubulin (with 6 µM of Glu for newborn mouse)1 Publication

    pH dependencei

    Optimum pH is 7.0.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei106Binds negatively charged residues of beta-tubulin C-terminal tailsBy similarity1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei201ATPBy similarity1
    Binding sitei203ATPBy similarity1
    Sitei352Binds negatively charged residues of beta-tubulin C-terminal tailsBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi188 – 191ATP bindingBy similarity4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDevelopmental protein, Ligase
    Biological processDifferentiation, Neurogenesis
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-8955332 Carboxyterminal post-translational modifications of tubulin

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Tubulin polyglutamylase TTLL7Curated (EC:6.-.-.-1 Publication)
    Alternative name(s):
    Tubulin--tyrosine ligase-like protein 7Curated
    Short name:
    mTTLL71 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Ttll7Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:1918142 Ttll7

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi349E → V: Loss of activity. 1 Publication1

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2401604

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003261631 – 912Tubulin polyglutamylase TTLL7Add BLAST912

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    A4Q9F0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    A4Q9F0

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    A4Q9F0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    A4Q9F0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed with highest levels in brain, testis and trachea. In brain, highly expressed in hippocampus, thalamus, olfactory bulb and cerebellum.2 Publications

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with both alpha- and beta-tubulin (via C-terminal tubulin tails).By similarity

    GO - Molecular functioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    A4Q9F0, 10 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000129369

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    A4Q9F0

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A4Q9F0

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 390TTLPROSITE-ProRule annotationAdd BLAST353

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni388 – 450c-MTBD regionBy similarityAdd BLAST63

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The enzyme uses its core to engage the disordered anionic tails of alpha- and beta-tubulin and the flexible c-MTBD (cationic microtubule binding domain) region to bind the microtubule and position itself for beta-tail modification. The c-MTBD region is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on alpha-tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.By similarity

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the tubulin--tyrosine ligase family.Sequence analysis

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2158 Eukaryota
    ENOG410XNWC LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000045569

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    A4Q9F0

    KEGG Orthology (KO)

    More...
    KOi
    K16583

    Database of Orthologous Groups

    More...
    OrthoDBi
    1251554at2759

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.1490.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013815 ATP_grasp_subdomain_1
    IPR004344 TTL/TTLL_fam

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03133 TTL, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51221 TTL, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 11 Publication (identifier: A4Q9F0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MPSLPQDGVI QGSSPVDLGT ELPYQCTMKR KVRKKKKKGI ITANVAGTKF
    60 70 80 90 100
    EIVRLVIDEM GFMKTPDEDE TSNLIWCDAA VQQEKITDLQ NYQRINHFPG
    110 120 130 140 150
    MGEICRKDFL ARNMTKMIKS RPMDYTFVPR TWIFPSEYTQ FQNYVKELKK
    160 170 180 190 200
    KRKQKTFIVK PANGAMGHGI SLIRNGDKVP SQDHLIVQEY IEKPFLMEGY
    210 220 230 240 250
    KFDLRIYILV TSCDPLKIFL YHDGLVRMGT EKYIPPNESN LTQLYMHLTN
    260 270 280 290 300
    YSVNKHNERF ERNETEDKGS KRSIKWFTEF LQANQHDVTK FWSDISELVV
    310 320 330 340 350
    KTLIVAEPHV LHAYRMCRPG QPPGSESVCF EVLGFDILLD RKLKPWLLEI
    360 370 380 390 400
    NRAPSFGTDQ KIDYDVKRGV LLNALKLLNI RTSDKRKNLA KQKAEAQRRL
    410 420 430 440 450
    YGQNPVRRLS PGSSDWEQQR HQLERRKEEL KERLLQVRKQ VSQEEHENRH
    460 470 480 490 500
    MGNYRRIYPP EDKALLEKYE GLLAVAFQTF LSGRAASFQR EMNNPLKKMR
    510 520 530 540 550
    EEDLLDLLEQ CEIDDEKLMG KTGRVRGPKP LCCMPECAEV TKKQKYYGSS
    560 570 580 590 600
    DSSYDSSSSS SNSELDENEK ELCQKRLDQV PYSLKHTSHC KIIQQPSGSH
    610 620 630 640 650
    NLIYSESPVY LTTLVFLSEF PDSMRRSVSC PRSISAHLPS RGDVRPFSSQ
    660 670 680 690 700
    QVIPLARPTS ASRSHSLNRA SSYARHLPHG SDTGSTNTLN ESLRQLKTKE
    710 720 730 740 750
    QEDDLTSQTL FVLKDMRIRF PGKSDAESEL LIEDIMDNWK HYKTKVASYW
    760 770 780 790 800
    LIKLDSVKQR KVLDIVKSSI RTVLPRIWRV PDAEELSLYR IFNRVFNRLL
    810 820 830 840 850
    WSHGQGLWSC FCDSGSSWES IFSKSPEVVT PLQLQCCQRL VELCKQCLLV
    860 870 880 890 900
    VYKYTTETRG PISGIGPDWG NSRYLLPGST QFLMRSPLYN MKYNSPGMTR
    910
    SNVLFTSRYG RL
    Length:912
    Mass (Da):105,501
    Last modified:May 15, 2007 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABCDD119BFF29336
    GO
    Isoform 21 Publication (identifier: A4Q9F0-2) [UniParc]FASTAAdd to basket
    Also known as: TTLL7S1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         596-609: PSGSHNLIYSESPV → SSKSISPTSLEEEL
         610-912: Missing.

    Note: May be due to an intron retention.
    Show »
    Length:609
    Mass (Da):70,782
    Checksum:iA63B6BB06FCBFD56
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0G2LB90A0A0G2LB90_MOUSE
    Tubulin polyglutamylase TTLL7
    Ttll7
    912Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9Q6C6E9Q6C6_MOUSE
    Tubulin polyglutamylase TTLL7
    Ttll7
    887Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PWB8E9PWB8_MOUSE
    Tubulin polyglutamylase TTLL7
    Ttll7
    892Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0G2JFF6A0A0G2JFF6_MOUSE
    Tubulin polyglutamylase TTLL7
    Ttll7
    47Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98F → Y in BAB29613 (PubMed:16141072).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052730596 – 609PSGSH…SESPV → SSKSISPTSLEEEL in isoform 2. 2 PublicationsAdd BLAST14
    Alternative sequenceiVSP_052731610 – 912Missing in isoform 2. 2 PublicationsAdd BLAST303

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AM690750 mRNA Translation: CAM84327.1
    AM690751 mRNA Translation: CAM84328.1
    AK014905 mRNA Translation: BAB29613.1
    AK083236 mRNA Translation: BAC38821.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS51094.2 [A4Q9F0-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001289887.1, NM_001302958.1 [A4Q9F0-2]

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    70892

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:70892

    UCSC genome browser

    More...
    UCSCi
    uc008rrw.2 mouse [A4Q9F0-2]
    uc008rrx.2 mouse [A4Q9F0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AM690750 mRNA Translation: CAM84327.1
    AM690751 mRNA Translation: CAM84328.1
    AK014905 mRNA Translation: BAB29613.1
    AK083236 mRNA Translation: BAC38821.1
    CCDSiCCDS51094.2 [A4Q9F0-1]
    RefSeqiNP_001289887.1, NM_001302958.1 [A4Q9F0-2]

    3D structure databases

    SMRiA4Q9F0
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiA4Q9F0, 10 interactors
    STRINGi10090.ENSMUSP00000129369

    Chemistry databases

    BindingDBiA4Q9F0
    ChEMBLiCHEMBL2401604

    PTM databases

    iPTMnetiA4Q9F0
    PhosphoSitePlusiA4Q9F0

    Proteomic databases

    PaxDbiA4Q9F0
    PRIDEiA4Q9F0

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    GeneIDi70892
    KEGGimmu:70892
    UCSCiuc008rrw.2 mouse [A4Q9F0-2]
    uc008rrx.2 mouse [A4Q9F0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    79739
    MGIiMGI:1918142 Ttll7

    Phylogenomic databases

    eggNOGiKOG2158 Eukaryota
    ENOG410XNWC LUCA
    HOGENOMiHOG000045569
    InParanoidiA4Q9F0
    KOiK16583
    OrthoDBi1251554at2759

    Enzyme and pathway databases

    ReactomeiR-MMU-8955332 Carboxyterminal post-translational modifications of tubulin

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:A4Q9F0

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Family and domain databases

    Gene3Di3.30.1490.20, 1 hit
    InterProiView protein in InterPro
    IPR013815 ATP_grasp_subdomain_1
    IPR004344 TTL/TTLL_fam
    PfamiView protein in Pfam
    PF03133 TTL, 1 hit
    PROSITEiView protein in PROSITE
    PS51221 TTL, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTLL7_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4Q9F0
    Secondary accession number(s): A4Q9E9, Q8C417, Q9D5V3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: May 15, 2007
    Last modified: May 8, 2019
    This is version 85 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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