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Entry version 62 (10 Feb 2021)
Sequence version 1 (15 May 2007)
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Protein
Submitted name:

Non ribosomal peptide synthetase for virginiamycin S

Gene

visE

Organism
Streptomyces virginiae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Non ribosomal peptide synthetase for virginiamycin SImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:visEImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces virginiaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1961 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1063O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2121O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1028 – 1103CarrierInterPro annotationAdd BLAST76
Domaini2086 – 2160CarrierInterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni489 – 515DisorderedSequence analysisAdd BLAST27

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.30.559.10, 3 hits
3.40.50.12780, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 3 hits
PF00550, PP-binding, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 2 hits
TIGR01720, NRPS-para261, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4PHL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQFDLVDPSG RLRLPPARRA AAAGSTGGEE MSGAKVASMA LTDAQLGVWF
60 70 80 90 100
AQARDPHSTA FNTGEYVELT GPLDAGRFTA AVRAAVEATE SLRLRFHTRA
110 120 130 140 150
DGEVRQRVVP ADESAWELRH VDVSAEPDPE AAADDLIRRQ LAAPMAVDGE
160 170 180 190 200
GPLFDQVLFT LGPGRHRWFQ QVHHLLLDGY GLRLVARRVA DAYNGAGTPA
210 220 230 240 250
EADDLAALVD AESAYRASRG HARDRAYWLT SWADRPEAPT LGTGPVARGD
260 270 280 290 300
APAAAEGGAV PLRRTVFLPA AVQEGLDALA RTAQTGWQVA ALAAVALYTR
310 320 330 340 350
RLTGAGEAVL GLPVTNRRSS RARRTPAMLT NVPPLRVPAR PDTDLTGLVT
360 370 380 390 400
EVRDRVAEVL RHQGYPYAEL RRELGLLAQD RPLHSIVANI MPFDHGLDFE
410 420 430 440 450
GIEAQVHPVS TGPVEDLKFS VYERPGGAGL RIDVEADALR HREEEVAAHL
460 470 480 490 500
ARFTALLHSF ATADPALPGG RLDVLAPGEH VQAAGEAFVP EPSTDEPSTD
510 520 530 540 550
EPSAHEPSTP DRPTTLPALF EAQAARTPQA VAVVDGHRQL TYRELDARAN
560 570 580 590 600
RLAHLLTARG AGPERTVALA LPRSADLVVA LLAVVKTGAA YLPLDPDYPA
610 620 630 640 650
ERLASMLADA GPSVIVATAA TRVVAPDRTA LVLLDDEPQA GLPDTAPRTK
660 670 680 690 700
HDPRHPAYVI YTSGSTGRPK GVVVTHHNVV RLFTAAQQHF GFGPSDVWTL
710 720 730 740 750
FHSYAFDFSV WEIWGPLLHG GRLVVVPYST SRSPGAFLDL LAEQRVTVLN
760 770 780 790 800
QTPSAFYQLI EADRERPRPT ALPALRHVVF GGEALDAPRL EGWYERHGHT
810 820 830 840 850
ASLSNMYGIT ETTVHVTHTA LDGPDGAPGS VGAPLADLRA HVLDGALRPA
860 870 880 890 900
PPGVTGELYV AGPGLARGYL GLPALTAERF VADPFAPAGD TGARMYRTGD
910 920 930 940 950
LVRRRADGTL EYVGRADHQV KIRGFRIELG EIEAALAALP SVAHAAVTAR
960 970 980 990 1000
EDTPGDRRLA AYAVPADGVP ADPAAWRREL AAVLPAHQLP ASFTPLDAIP
1010 1020 1030 1040 1050
LTVNGKLDRA ALPAPGPAEA ASWATQAAAA GPLEELLCRL FARILGVHEV
1060 1070 1080 1090 1100
GPRSDFFALG GHSVIANRLL SAARSELGVE LTIEDLFARP TPAGLARLAR
1110 1120 1130 1140 1150
GADTARPRLR PAGDPDGPAV LSPAQQRMWV IREVEGRAPT YNMPLALRLT
1160 1170 1180 1190 1200
GALDRGAMQA ALGDLIGRHD TLRTICPAGP DGPLPRVLPL DDVPPWLTET
1210 1220 1230 1240 1250
EVAESDLAQA LTSAAREPFD LDTQIPLRAH LFTLAPGEHV LLLVLHHIAG
1260 1270 1280 1290 1300
DGWSLRPLFG DLAAAYDARS KGTAPRPEPL PVTYRDFALW QRELLGDESE
1310 1320 1330 1340 1350
PASLGARQLD HWHHALAGLP DQLQLPYDRP RPPVARHRGG SVPLTIGPAL
1360 1370 1380 1390 1400
HAQLDGLART GGATVHMVLQ AALAALLTRL GAGTDVPIGC PTAGRDEEAL
1410 1420 1430 1440 1450
DGLVGFFVNP VVVRADTSGD PAFAELLTRV RTTALAAYTH QDVPFDRVVE
1460 1470 1480 1490 1500
RLQPARSAAR HPLFQVVLSY QESEARPRLA GLVVRREPVD FGVAKFDLTF
1510 1520 1530 1540 1550
NLVEHRDDAG APDGIHGDLE FDLDLFDPAT AQAVARRLLA LLEAVAAGPE
1560 1570 1580 1590 1600
LPISRFDLVD DAERAMLRRW NDTAAPVPDT GLAELFTAQA RRTPDATALV
1610 1620 1630 1640 1650
AGDTELTYAQ LDARAGALAA RLTALGIGPE CPVAVLQERS ADLVVSLLAV
1660 1670 1680 1690 1700
LRAGGFYVPL NHRNPASRMS QIMTMAGARV LLTDRAAHER HRCHAWAGQA
1710 1720 1730 1740 1750
EVVVVDDPAP ASAPAPAAVV PGHPDRLAYV MYTSGSTGTP KGVAITHRDV
1760 1770 1780 1790 1800
AVLAADRCWR TGNQQRVLLH SPYSFDTSQY ELWVPLLSGG TVVVAPPGDL
1810 1820 1830 1840 1850
DTAALREALT RGRVTGMWLT SGLFNLLAEE SPECFRGVRE VWTGGDVVSP
1860 1870 1880 1890 1900
AAVTRVLAAS PDTLVVDGYG PTETTTFSTH HFMRAPWTEE TTVPIGSPLD
1910 1920 1930 1940 1950
NTTCHVLDQR LRPVPPGVTG ELYIGGARLA RGYLGRPDAT AERFVADPSG
1960 1970 1980 1990 2000
TPGARMYRTG DLVRRRADGI LEFLGRADHQ VKVRGFRIEL GEIESVIGRH
2010 2020 2030 2040 2050
PTVAQSAVLV REDRPGDKRV TAYVVPAAAA AADAGELRRH VAASLPDYMV
2060 2070 2080 2090 2100
PAAVVLLDRL PLTPNGKLDR RQLPVPEFAP AGDHRAPAGP REELLAGLFA
2110 2120 2130 2140 2150
GVLGLEQVGT HDSFFDLGGD SIMAIQLVGR ARRSGLLLSP AQVFEHKTVA
2160 2170 2180 2190 2200
ALAGVATAAA DSGPAPGTAP ADDRAWGEVP LTPVMHWLRE RGGPVEAFSQ
2210 2220 2230 2240 2250
SLLVRVPAGL GEQRLATALR ALADQHDMLR AVLSSDPDSG WRLRIEPPGG
2260 2270 2280 2290 2300
GSAEAWARRV DTAGHTDDAL RTLITTEAAA ARSRLDPWSG VMGQAVWFDA
2310 2320 2330 2340 2350
GQNRSGRLLL TLHHLVVDGV SWRILLPDLE AAWQAATGDT APRPAPAGTS
2360 2370 2380 2390 2400
FRSWARHLAA EAARPARRAE LDLWTGRLAA PALPVTDRPL DPARDTSATA
2410 2420 2430 2440 2450
RSLTLTLPAA ATEPLLTTVP ATFHAKVDDV LLTAFALAVA DWRARRGLGD
2460 2470 2480 2490 2500
ASAVLLDLEG HGREPGDSGA DLSRTVGWFT SLYPVRLDVG PLDRRDALSG
2510 2520 2530 2540 2550
GPAAGQAVKR VKEQLRELPD GGLGHGLLRH LNAETAPLLA ALPTPDIGFN
2560 2570 2580 2590 2600
YLGRFKEPEG PDAEWTVTPD AESLGEGTDP RLPMAHGVEL NALTLDGPGG
2610 2620 2630 2640 2650
PRLTATWSWP QHLLDEGSVR DLGQGWFRAL EALTAHAERP DAGGHTPSDF
2660 2670
SLVSLNQAQI DRLEAMWKVA R
Length:2,671
Mass (Da):285,171
Last modified:May 15, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9205FF7CDB944D41
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB283030 Genomic DNA Translation: BAF50711.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB283030 Genomic DNA Translation: BAF50711.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.559.10, 3 hits
3.40.50.12780, 2 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 3 hits
PF00550, PP-binding, 2 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 2 hits
SUPFAMiSSF47336, SSF47336, 2 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 2 hits
TIGR01720, NRPS-para261, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4PHL4_STRVG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4PHL4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 10, 2021
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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