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Protein
Submitted name:

Histone-lysine N-methyltransferase

Gene

met-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • histone H3-K36 methylation Source: WormBase
  • histone H3-K9 methylation Source: WormBase
  • negative regulation of transcription by RNA polymerase II Source: WormBase
  • negative regulation of vulval development Source: WormBase

Keywordsi

Molecular functionMethyltransferaseSAAS annotationImported, Transferase
LigandS-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferaseImported
Gene namesi
Name:met-1Imported
ORF Names:C43E11.3Imported, CELE_C43E11.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC43E11.3b ; CE08681 ; WBGene00016603 ; met-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

EPDiA4LBC3

Expressioni

Gene expression databases

BgeeiWBGene00016603
ExpressionAtlasiA4LBC3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA4LBC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini622 – 667AWSInterPro annotationAdd BLAST46
Domaini669 – 791SETInterPro annotationAdd BLAST123
Domaini798 – 814Post-SETInterPro annotationAdd BLAST17
Domaini1352 – 1379WWInterPro annotationAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili471 – 491Sequence analysisAdd BLAST21
Coiled coili547 – 600Sequence analysisAdd BLAST54
Coiled coili1305 – 1347Sequence analysisAdd BLAST43

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4442 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00780000121845
HOGENOMiHOG000263480
OrthoDBiEOG091G040P

Family and domain databases

CDDicd00201 WW, 1 hit
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4LBC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQTRRKTAA AVQDGGAVKE NKAKPPAPQT PTKRAKRGRP PKIKTDANTL
60 70 80 90 100
NTPSTSSNLV DDKLLIESES QDSILTNEAD SFLEKEVEEI EDSSDILPDK
110 120 130 140 150
INSPEKPSVL VKRRSSTRLK VKTDEDEKDV PVNIEVAVLE EKSIQIEPTS
160 170 180 190 200
PAHPEDPQPS TSSLPLVEPI EDIVEPNEPT SSADPPVSNI KDEDIKEEEP
210 220 230 240 250
LIKKPASDES ESMDIANSES GNDSDSSEAD PRTIPSFSIP LPDTPPPNFA
260 270 280 290 300
KRGEIHVDVD QKNSKQSGES QSPWERAREK SASNPLSSPT MSRPRIHFLH
310 320 330 340 350
PAYQSFTNDS VSPLPPPPPE PAPAREKVEN GGPTTFKMTF KKAANIPILK
360 370 380 390 400
TSAFEQPSSP PPSSSVSSSI SLSEVNSSTS IASESSPAKR SSNFDLTASN
410 420 430 440 450
ELPPPQMVEL PKLSFFNMPP AVRSAEDDSA MTSEEPILLL RSPNSATPDD
460 470 480 490 500
DALFLTTPPP PKMTESEIQA LKVATEKVNQ VIARREDSEK DVRHREDRDD
510 520 530 540 550
YDRRRDDRDR RSRKTDSERN DQRGRQREDD ERRARERERE VTKRHDRERE
560 570 580 590 600
EMRLQKQKDE ERRKKDEEER IQKENDEKKQ KEDEAKMEEE KKKIKEEEMK
610 620 630 640 650
IPEFELISES KYLTRNANKK KTESLTCECH RTGGNCSDNT CVNRAMLTEC
660 670 680 690 700
PSSCQVKCKN QRFAKKKYAA VEAFHTGTAK GCGLRAVKDI KKGRFIIEYI
710 720 730 740 750
GEVVERDDYE KRKTKYAADK KHKHHYLCDT GVYTIDATVY GNPSRFVNHS
760 770 780 790 800
CDPNAICEKW SVPRTPGDVN RVGFFSKRFI KAGEEITFDY QFVNYGRDAQ
810 820 830 840 850
QCFCGSASCS GWIGQKPEEF SSDEDDDIVT TRHINMDEEE EEKLEGLDHL
860 870 880 890 900
GNHERNEVIK DMLDDLVIRN KKHARKVITI ASAMTDYSQR VDVIQEIFSS
910 920 930 940 950
DTSVTVQKFY AKEGMATLMA EWLSEDDYSL DNLKLVQAIL KALHTELFDS
960 970 980 990 1000
CAKNDRLLRD STSRWVNAKM DEYVDIQVIA DSLIACVEDP VQEYKDVCKV
1010 1020 1030 1040 1050
IEKGLVENFT RAKEMAYRLN QYWFNRSVSF KIPKKIRDPV PKDVPVRQED
1060 1070 1080 1090 1100
ATTSSQSHDN SSRTVSPNHR HHSSSYSNSC YQEREPSHIR FFNNGNDVHQ
1110 1120 1130 1140 1150
YRFGGYHGNN YNDNYFSRRP NKDSYRDRRR FNGRRSRSRS RSVSPQNYKR
1160 1170 1180 1190 1200
RKLDEHDNNH RQRSPIRDRH TSPGGEKTPS SNNSGERNYK RLDIRGARIK
1210 1220 1230 1240 1250
TIKEDLEAAA AAAAAAAVPS EVQAYPHEHT AVHQSVYQMP GYESYGVYDP
1260 1270 1280 1290 1300
VNGVYMYPHP GAGYYPPAYP QQPIMLTMDT LPPNDRLGEL YEKASIEQLA
1310 1320 1330 1340 1350
QRDAIVRQEL ELIRIQIERK TAQKEAIKAA CRRANEEEAK RQEALAKTKY
1360 1370 1380 1390 1400
VWAIAKSEAG ETYYYNKITK ETQWTAPTPV QGLLEPACGA SPDTTVVIAD
1410 1420 1430 1440 1450
EITEEEQQAE VLEKPRVVKE EVIEPGSQSE TQKESPEKVR VVVPKVEVER
1460 1470 1480 1490 1500
SPSPKSSRDR EKDREKSREK DRERDRDRRE GSKHRDSYHG HRNGSSSVSE
1510 1520 1530 1540 1550
RRMREFKHEL ERSTRSAVRS RLQHQRDASS DKTTWLIKLI YREIFKRESA
1560 1570 1580 1590
QSGFDYRFSE NTDKKVKNYV KSYIDRKLES NDLWKEYSRP
Length:1,590
Mass (Da):181,721
Last modified:May 1, 2007 - v1
Checksum:i084E00974199EB1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD65167.1
PIRiB87754
RefSeqiNP_871842.2, NM_182042.2
UniGeneiCel.4961

Genome annotation databases

EnsemblMetazoaiC43E11.3b; C43E11.3b; WBGene00016603
GeneIDi172026
UCSCiC43E11.3a c. elegans

Similar proteinsi

Entry informationi

Entry nameiA4LBC3_CAEEL
AccessioniPrimary (citable) accession number: A4LBC3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 18, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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