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Protein

Beta-crystallin A2

Gene

CRYBA2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin A2
Alternative name(s):
Beta-A2 crystallin
Gene namesi
Name:CRYBA2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002896111 – 197Beta-crystallin A2Add BLAST197

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000183

Structurei

3D structure databases

ProteinModelPortaliA4L9I9
SMRiA4L9I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 52Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST41
Domaini53 – 99Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST47
Domaini106 – 147Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST42
Domaini148 – 196Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 11N-terminal armAdd BLAST11
Regioni100 – 105Connecting peptide6

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IH1M Eukaryota
ENOG4110S6G LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234388
HOVERGENiHBG003364
InParanoidiA4L9I9
OMAiFGTQAHT
OrthoDBiEOG091G0JYH
TreeFamiTF331401

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequencei

Sequence statusi: Complete.

A4L9I9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSASAPGPA PACLTLWDEE DFQGRRCRLL SDCANVGERG GLRRVRSVKV
60 70 80 90 100
ENGAWVAFEY PDFQGQQFIL EKGDYPRWSA WSGSSGHHSN QLLSFRPVLC
110 120 130 140 150
ANHSDSRVTL FEGENFQGCK FELSDDYPSL PSMGWASKEV GSLKVSSGAW
160 170 180 190
VAYQYPGYRG YQYVLERDRH SGEFRNYSEF GTQAHTGQLQ SIRRVQH
Length:197
Mass (Da):22,213
Last modified:May 1, 2007 - v1
Checksum:iA011C40966822804
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF457886 mRNA Translation: ABO41862.1
RefSeqiNP_001093440.1, NM_001099970.1
UniGeneiOcu.3908

Genome annotation databases

EnsembliENSOCUT00000000206; ENSOCUP00000000183; ENSOCUG00000000206
GeneIDi100101619
KEGGiocu:100101619

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF457886 mRNA Translation: ABO41862.1
RefSeqiNP_001093440.1, NM_001099970.1
UniGeneiOcu.3908

3D structure databases

ProteinModelPortaliA4L9I9
SMRiA4L9I9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000183

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000000206; ENSOCUP00000000183; ENSOCUG00000000206
GeneIDi100101619
KEGGiocu:100101619

Organism-specific databases

CTDi1412

Phylogenomic databases

eggNOGiENOG410IH1M Eukaryota
ENOG4110S6G LUCA
GeneTreeiENSGT00760000118812
HOGENOMiHOG000234388
HOVERGENiHBG003364
InParanoidiA4L9I9
OMAiFGTQAHT
OrthoDBiEOG091G0JYH
TreeFamiTF331401

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRBA2_RABIT
AccessioniPrimary (citable) accession number: A4L9I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2007
Last modified: November 22, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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