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Entry version 72 (02 Dec 2020)
Sequence version 3 (13 Jul 2010)
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Protein

Genome polyprotein

Gene
N/A
Organism
Triticum mosaic virus (isolate Triticum aestivum/United States/U06-123/2006) (TriMV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
has RNA-binding and proteolytic activities.By similarity
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.By similarity
involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei286For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei301For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei333For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei737For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei809For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2140For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2174For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2243For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1291 – 1298ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
Alternative name(s):
N-terminal protein (EC:3.4.-.-)
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTriticum mosaic virus (isolate Triticum aestivum/United States/U06-123/2006) (TriMV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1289472 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaStelpaviricetesPatataviralesPotyviridaePoacevirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiTriticum aestivum (Wheat) [TaxID: 4565]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008255 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004200271 – 3112Genome polyproteinAdd BLAST3112
ChainiPRO_00003954861 – 383P1 proteinaseSequence analysisAdd BLAST383
ChainiPRO_0000395487384 – 850Helper component proteinaseSequence analysisAdd BLAST467
ChainiPRO_0000395488851 – 1148Protein P3By similarityAdd BLAST298
ChainiPRO_00003954891149 – 12046 kDa protein 1By similarityAdd BLAST56
ChainiPRO_00003954901205 – 1852Cytoplasmic inclusion proteinBy similarityAdd BLAST648
ChainiPRO_00003954911853 – 19026 kDa protein 2By similarityAdd BLAST50
ChainiPRO_00003954921903 – 2095Viral genome-linked proteinBy similarityAdd BLAST193
ChainiPRO_00003954932096 – 2328Nuclear inclusion protein ABy similarityAdd BLAST233
ChainiPRO_00003954942329 – 2818Nuclear inclusion protein BBy similarityAdd BLAST490
ChainiPRO_00002888362819 – 3112Capsid proteinBy similarityAdd BLAST294

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Genome polyprotein of potyviruses undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei383 – 384Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei850 – 851Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1148 – 1149Cleavage; by NIa-proBy similarity2
Sitei1204 – 1205Cleavage; by NIa-proBy similarity2
Sitei1852 – 1853Cleavage; by NIa-proBy similarity2
Sitei1902 – 1903Cleavage; by NIa-proBy similarity2
Sitei2095 – 2096Cleavage; by NIa-proBy similarity2
Sitei2328 – 2329Cleavage; by NIa-proBy similarity2
Sitei2818 – 2819Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A4KZ49

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini234 – 383Peptidase S30PROSITE-ProRule annotationAdd BLAST150
Domaini729 – 850Peptidase C6PROSITE-ProRule annotationAdd BLAST122
Domaini1278 – 1429Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST152
Domaini1444 – 1627Helicase C-terminalPROSITE-ProRule annotationAdd BLAST184
Domaini2096 – 2311Peptidase C4PROSITE-ProRule annotationAdd BLAST216
Domaini2569 – 2687RdRp catalyticPROSITE-ProRule annotationAdd BLAST119

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1379 – 1382DECH box4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR025910, P1_Ser_Pept_dom
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF13611, Peptidase_S76, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A4KZ49-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKKMMWVP KSAHKAPVVS REPVIRKKEW VARQIPKYIP VSNPSDCRDE
60 70 80 90 100
ISQTLLHFDS EEAVYDFVWR FPMGSIFWDT NGRIKPVVNC LLRATRMNLD
110 120 130 140 150
YDVAADVYVC RDCLSCASSY MYFSNYHYDC RELRENHEAV VSCKYEQHIV
160 170 180 190 200
STFDVFPRYC TQEIEQNVVN WMTETLERYD NEPLRIEKQL QFYNHKTEQM
210 220 230 240 250
ESRVQEVQVT TAEYAVSDTY VPQQLSRKGS VSAKLTQRRA NKIIMRTHEV
260 270 280 290 300
ENLIRETIDL CDERQIPITF VDVKHKRCLP RIPLRHMQAK PDISEIVEQG
310 320 330 340 350
DMYNEVGQFI EQYQNLAEPF RVIRDYEVTR GWSGVILHRD DLALDPQTQA
360 370 380 390 400
RCLNNLFVVM GRCEHGHLQN ALRPDCLEGL TYYSDTFGKV FNESLVKHHP
410 420 430 440 450
GKHQFRIGSR TDYEWEELAM WVNAVCPVSF RCADCRPPQS LNEYIENIRM
460 470 480 490 500
SKAMAELAGR QDALSKTLHK WTTMLISSVL TTEIRARDNL EPIQERIFTR
510 520 530 540 550
NMPLGPLYDV AGAMNRAVID IQTAVQNMQL SIGNSNMNEQ QRNQTLLNEI
560 570 580 590 600
NKIKQHSFMQ TKEMLSRFEN IAQTYQNIIS SASQPLSIHS MRQLMMDSRM
610 620 630 640 650
DESFEFDIMR KKGSIASIAP MAFRTFEDIY SQPGVYNQKW LNLTPSGRFQ
660 670 680 690 700
TDIDYLRLDL PIDVIQKKKH VVNRNEIKEE TCYVIVGQVN VSFCEVVARC
710 720 730 740 750
FVPIPHVLRV GSPQNPTMIK IQDQEGGKTL VPKSGFCYVL QLVLMLGYVP
760 770 780 790 800
DQLTAAFVKD VGIVVESLGP WPLFVDYLGA IKNLIIRYPT TIKAPTALHI
810 820 830 840 850
VDHVDTVIHV MTTLGCVNKG EHYLTLQSVA QLHDAAMTVN IETFKDYRIG
860 870 880 890 900
GVVPQLKHML QSEEHMLEVL EAKPQWLVHL LLSPTQIWAL SQSVVKYQVI
910 920 930 940 950
HKVMTSNPDL AVALAQLVAI SSNFSIFKNT EHVIQKYFEV SKQLQNVSGV
960 970 980 990 1000
ILGEHNEYFE TAFAQYSALR FSTDVVLLMD QFSTRKKTLD DLEDYYRKTI
1010 1020 1030 1040 1050
PSILIECGLL GPSDFGWRKR LVRGVVDRGS GLKSTVKSLG SFSTKEKWIS
1060 1070 1080 1090 1100
WSGLGSGTIT CVKFPFVCLQ RSGSWLYSST KTTAFNAVWM AGIKCVKSNV
1110 1120 1130 1140 1150
RSILLDSALY GAITLALLCA IKLIRKAFRF VEGLIKEDTS DDEDYVLHAK
1160 1170 1180 1190 1200
AASDSLYIQC LAWLALVVGC FNSGLANDIY FSTTKYRTLL DMVKTAHSDS
1210 1220 1230 1240 1250
FVFHAGDEEE GEIVELITRD NFVDYVYNHS DPLMEFDSET LLGWYTRISY
1260 1270 1280 1290 1300
QGRVLEHPLR VGTNCHLTRE NVDEIAKNIA TGAGNEFIVV GDVGSGKSTK
1310 1320 1330 1340 1350
LPIAVSTYGP VLILVPSREL VNNLCSSIWH VGKKQASTYM MNCITRGTSN
1360 1370 1380 1390 1400
ISIMTYGYAL ALFSHCPIEL QKYRFIQMDE CHEFSSHMIT FYSWWRESGK
1410 1420 1430 1440 1450
FTKLFKTTAT PPGTVIKGGC VPTNHKVDVI EIRDVSVEEF CRRSIDSHAE
1460 1470 1480 1490 1500
GLRSLMPNGG RVIMFVPSRR ECELARSSLI SIPGARTWVV YRAAATQATK
1510 1520 1530 1540 1550
LVAELADDKH YFQIIITTTV LQNGVNLDPD CVVDFGQTFE AAYDRDSRQL
1560 1570 1580 1590 1600
GVRRRNINPG ELIQRVGRVG RNKPGKFIQV GKRLEHEVVP NSCCVTDAIL
1610 1620 1630 1640 1650
MSFTLELAPF ISSHLIDEVN FVTREQVRTA MKFSAPLLFM IHYVRRDGRM
1660 1670 1680 1690 1700
LNGYYQQLKG LLLQTSDVAL CDTLVGDAET NSFLTLRQYQ LRGIIEAQEV
1710 1720 1730 1740 1750
LPDLPIPFYS SEFALPFYLE IGQITKEAIR ARSFTLRIKT PDVKKAVMRL
1760 1770 1780 1790 1800
STSATQIDQT IGILRTRLQL TRERLSKFSE LKATAHNLRL TPIFNTCFDM
1810 1820 1830 1840 1850
GAAKSESTLR ASLTAGEELL SALELARTEK SDKALEKLIL DNPVLGDCLV
1860 1870 1880 1890 1900
FHGGPEEYFD QTLFQTSTGL INKYTVGIAC LTVGLGCTIW YYLKKREKYV
1910 1920 1930 1940 1950
MHGKVHTRET GLTTNHLFVP GMKEHIQEWT GGDHEIGNRF GEAYKRRFIG
1960 1970 1980 1990 2000
RQPTEEQKLS KEKWDKREGQ QTSVYKTLYD LDPTKFKYVV VECPDFDLKK
2010 2020 2030 2040 2050
KLNRQEKKQL DTTIVEACRT RMLDKGQHDF KDVERATVYL FNDNGVGHKV
2060 2070 2080 2090 2100
QLTPHNPLAV SRTTTHPVGF PAEAGRLRQT GQAMEMTPEE LEKALDDNYV
2110 2120 2130 2140 2150
PHSRCQIDIS HLHRHLAIVN TGGMSTQCFI TQTMCVAPYH LAMGFKDNTK
2160 2170 2180 2190 2200
LTIYCSNGVY VMPVPKVEKM ENMDLVVFRM PQDFPPLKRC ATIREPKSSD
2210 2220 2230 2240 2250
EVTLITGKRT THGIQLQFSK VVSIDRKSDT VWKYMIDSVP GVCGGMVMCV
2260 2270 2280 2290 2300
EDGCVVGFHS AAAIRNKVSN GSIFTPVTPQ LLDSLQSSEG HLFDWYFNDD
2310 2320 2330 2340 2350
LISWKGVPTN MDPRNFPVSE TISEFIFHND SKGHGTDKYY GENLTIEGRV
2360 2370 2380 2390 2400
LQSFNTRHVV KGLDDAFAEY VNKFGEPPAD TFTHLPSDLS SDAFYKDFMK
2410 2420 2430 2440 2450
YSTPVEVGTV NIENFEKAVQ AVVELLEQQG FEQGEFSPEM DFYKILNSFN
2460 2470 2480 2490 2500
LDTAMGALYQ CKKKDVLPMA SHEQLATWFW NSLENLATGK LGLWKASLKA
2510 2520 2530 2540 2550
ELRPKEKVLE KKTRVFTAAP FDVSFGAKAF VDDFNNKFYA TQAGSNWTVG
2560 2570 2580 2590 2600
INKFNCGWDE LARRFNPDWK FIDADGSRYD SSLTPLLFNA VLRIRQHFLR
2610 2620 2630 2640 2650
ANGFERRMLS NFYTQLVWTP ISTITGQIVK KNKGGPSGQP STVVDNTMML
2660 2670 2680 2690 2700
MIAVEYAKLQ YGVTDLKYVC NGDDLILNAP QGVCETIRAN FSHSFKELGL
2710 2720 2730 2740 2750
TYEFEQEVDS IDQVEYMSHK WIDCGGVLIP KLKPERIVSV LQWNKSLDLA
2760 2770 2780 2790 2800
SQANKINAAW IESFGYGDLS KFIREYANWW GERNGQVGFL CSEEKVASLY
2810 2820 2830 2840 2850
LTNDVTIHTE EHDEFVFHSG ADQSGVVKDQ TGDKAEGSGT KTEDPPNQTT
2860 2870 2880 2890 2900
DPVNNPSNGG NKDAPQNLNA TVVTKSYTYI PPIMKSLVTI DTAKKMADYT
2910 2920 2930 2940 2950
PPDALISTQA CTLEQFGRWA NAAANGLGLS MQAFQTDVVP YWIYWCIVNS
2960 2970 2980 2990 3000
ASDEHKKLSS WTKVNMTIDD ATGQINLNEG EAQTIYEMSP MFDEAKPTLR
3010 3020 3030 3040 3050
AVMRHFGALA YRWVKFSIAK RKPIIPHNAI KAGLMDVTYF PCCIDFVTVD
3060 3070 3080 3090 3100
QLSPQEQNVR NQVINARVSD TPRALFKHAQ RAGAGEEDTN LRRDDDANYG
3110
RTRVGGAMFG TR
Length:3,112
Mass (Da):352,841
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B066BBD6C5D5151
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2819S → E AA sequence (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
FJ263671 Genomic RNA Translation: ABO41208.2

NCBI Reference Sequences

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RefSeqi
YP_002956073.1, NC_012799.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
7984336

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
vg:7984336

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ263671 Genomic RNA Translation: ABO41208.2
RefSeqiYP_002956073.1, NC_012799.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA4KZ49

Genome annotation databases

GeneIDi7984336
KEGGivg:7984336

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR025910, P1_Ser_Pept_dom
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF13611, Peptidase_S76, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_TRMVU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4KZ49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 13, 2010
Last modified: December 2, 2020
This is version 72 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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