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UniProtKB - A4KZ49 (POLG_TRMVU)

Entry version 72 (02 Dec 2020)
Sequence version 3 (13 Jul 2010)
Previous versions | rss
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Protein

Genome polyprotein

Gene
N/A
Organism
Triticum mosaic virus (isolate Triticum aestivum/United States/U06-123/2006) (TriMV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
has RNA-binding and proteolytic activities.By similarity
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.By similarity
involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei286For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei301For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei333For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei737For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei809For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2140For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2174For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2243For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1291 – 1298ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase
Alternative name(s):
N-terminal protein (EC:3.4.-.-)
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
Protein P3
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Viral genome-linked protein
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTriticum mosaic virus (isolate Triticum aestivum/United States/U06-123/2006) (TriMV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1289472 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Stelpaviricetes › Patatavirales › Potyviridae › Poacevirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiTriticum aestivum (Wheat) [TaxID: 4565]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008255 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004200271 – 3112Genome polyproteinAdd BLAST3112
ChainiPRO_00003954861 – 383P1 proteinaseSequence analysisAdd BLAST383
ChainiPRO_0000395487384 – 850Helper component proteinaseSequence analysisAdd BLAST467
ChainiPRO_0000395488851 – 1148Protein P3By similarityAdd BLAST298
ChainiPRO_00003954891149 – 12046 kDa protein 1By similarityAdd BLAST56
ChainiPRO_00003954901205 – 1852Cytoplasmic inclusion proteinBy similarityAdd BLAST648
ChainiPRO_00003954911853 – 19026 kDa protein 2By similarityAdd BLAST50
ChainiPRO_00003954921903 – 2095Viral genome-linked proteinBy similarityAdd BLAST193
ChainiPRO_00003954932096 – 2328Nuclear inclusion protein ABy similarityAdd BLAST233
ChainiPRO_00003954942329 – 2818Nuclear inclusion protein BBy similarityAdd BLAST490
ChainiPRO_00002888362819 – 3112Capsid proteinBy similarityAdd BLAST294

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Genome polyprotein of potyviruses undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei383 – 384Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei850 – 851Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1148 – 1149Cleavage; by NIa-proBy similarity2
Sitei1204 – 1205Cleavage; by NIa-proBy similarity2
Sitei1852 – 1853Cleavage; by NIa-proBy similarity2
Sitei1902 – 1903Cleavage; by NIa-proBy similarity2
Sitei2095 – 2096Cleavage; by NIa-proBy similarity2
Sitei2328 – 2329Cleavage; by NIa-proBy similarity2
Sitei2818 – 2819Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A4KZ49

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini234 – 383Peptidase S30PROSITE-ProRule annotationAdd BLAST150
Domaini729 – 850Peptidase C6PROSITE-ProRule annotationAdd BLAST122
Domaini1278 – 1429Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST152
Domaini1444 – 1627Helicase C-terminalPROSITE-ProRule annotationAdd BLAST184
Domaini2096 – 2311Peptidase C4PROSITE-ProRule annotationAdd BLAST216
Domaini2569 – 2687RdRp catalyticPROSITE-ProRule annotationAdd BLAST119

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1379 – 1382DECH box4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potyviridae genome polyprotein family.Curated

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR025910, P1_Ser_Pept_dom
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF13611, Peptidase_S76, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A4KZ49-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKKMMWVP KSAHKAPVVS REPVIRKKEW VARQIPKYIP VSNPSDCRDE 
        60         70         80         90        100
ISQTLLHFDS EEAVYDFVWR FPMGSIFWDT NGRIKPVVNC LLRATRMNLD 
       110        120        130        140        150
YDVAADVYVC RDCLSCASSY MYFSNYHYDC RELRENHEAV VSCKYEQHIV 
       160        170        180        190        200
STFDVFPRYC TQEIEQNVVN WMTETLERYD NEPLRIEKQL QFYNHKTEQM 
       210        220        230        240        250
ESRVQEVQVT TAEYAVSDTY VPQQLSRKGS VSAKLTQRRA NKIIMRTHEV 
       260        270        280        290        300
ENLIRETIDL CDERQIPITF VDVKHKRCLP RIPLRHMQAK PDISEIVEQG 
       310        320        330        340        350
DMYNEVGQFI EQYQNLAEPF RVIRDYEVTR GWSGVILHRD DLALDPQTQA 
       360        370        380        390        400
RCLNNLFVVM GRCEHGHLQN ALRPDCLEGL TYYSDTFGKV FNESLVKHHP 
       410        420        430        440        450
GKHQFRIGSR TDYEWEELAM WVNAVCPVSF RCADCRPPQS LNEYIENIRM 
       460        470        480        490        500
SKAMAELAGR QDALSKTLHK WTTMLISSVL TTEIRARDNL EPIQERIFTR 
       510        520        530        540        550
NMPLGPLYDV AGAMNRAVID IQTAVQNMQL SIGNSNMNEQ QRNQTLLNEI 
       560        570        580        590        600
NKIKQHSFMQ TKEMLSRFEN IAQTYQNIIS SASQPLSIHS MRQLMMDSRM 
       610        620        630        640        650
DESFEFDIMR KKGSIASIAP MAFRTFEDIY SQPGVYNQKW LNLTPSGRFQ 
       660        670        680        690        700
TDIDYLRLDL PIDVIQKKKH VVNRNEIKEE TCYVIVGQVN VSFCEVVARC 
       710        720        730        740        750
FVPIPHVLRV GSPQNPTMIK IQDQEGGKTL VPKSGFCYVL QLVLMLGYVP 
       760        770        780        790        800
DQLTAAFVKD VGIVVESLGP WPLFVDYLGA IKNLIIRYPT TIKAPTALHI 
       810        820        830        840        850
VDHVDTVIHV MTTLGCVNKG EHYLTLQSVA QLHDAAMTVN IETFKDYRIG 
       860        870        880        890        900
GVVPQLKHML QSEEHMLEVL EAKPQWLVHL LLSPTQIWAL SQSVVKYQVI 
       910        920        930        940        950
HKVMTSNPDL AVALAQLVAI SSNFSIFKNT EHVIQKYFEV SKQLQNVSGV 
       960        970        980        990       1000
ILGEHNEYFE TAFAQYSALR FSTDVVLLMD QFSTRKKTLD DLEDYYRKTI 
      1010       1020       1030       1040       1050
PSILIECGLL GPSDFGWRKR LVRGVVDRGS GLKSTVKSLG SFSTKEKWIS 
      1060       1070       1080       1090       1100
WSGLGSGTIT CVKFPFVCLQ RSGSWLYSST KTTAFNAVWM AGIKCVKSNV 
      1110       1120       1130       1140       1150
RSILLDSALY GAITLALLCA IKLIRKAFRF VEGLIKEDTS DDEDYVLHAK 
      1160       1170       1180       1190       1200
AASDSLYIQC LAWLALVVGC FNSGLANDIY FSTTKYRTLL DMVKTAHSDS 
      1210       1220       1230       1240       1250
FVFHAGDEEE GEIVELITRD NFVDYVYNHS DPLMEFDSET LLGWYTRISY 
      1260       1270       1280       1290       1300
QGRVLEHPLR VGTNCHLTRE NVDEIAKNIA TGAGNEFIVV GDVGSGKSTK 
      1310       1320       1330       1340       1350
LPIAVSTYGP VLILVPSREL VNNLCSSIWH VGKKQASTYM MNCITRGTSN 
      1360       1370       1380       1390       1400
ISIMTYGYAL ALFSHCPIEL QKYRFIQMDE CHEFSSHMIT FYSWWRESGK 
      1410       1420       1430       1440       1450
FTKLFKTTAT PPGTVIKGGC VPTNHKVDVI EIRDVSVEEF CRRSIDSHAE 
      1460       1470       1480       1490       1500
GLRSLMPNGG RVIMFVPSRR ECELARSSLI SIPGARTWVV YRAAATQATK 
      1510       1520       1530       1540       1550
LVAELADDKH YFQIIITTTV LQNGVNLDPD CVVDFGQTFE AAYDRDSRQL 
      1560       1570       1580       1590       1600
GVRRRNINPG ELIQRVGRVG RNKPGKFIQV GKRLEHEVVP NSCCVTDAIL 
      1610       1620       1630       1640       1650
MSFTLELAPF ISSHLIDEVN FVTREQVRTA MKFSAPLLFM IHYVRRDGRM 
      1660       1670       1680       1690       1700
LNGYYQQLKG LLLQTSDVAL CDTLVGDAET NSFLTLRQYQ LRGIIEAQEV 
      1710       1720       1730       1740       1750
LPDLPIPFYS SEFALPFYLE IGQITKEAIR ARSFTLRIKT PDVKKAVMRL 
      1760       1770       1780       1790       1800
STSATQIDQT IGILRTRLQL TRERLSKFSE LKATAHNLRL TPIFNTCFDM 
      1810       1820       1830       1840       1850
GAAKSESTLR ASLTAGEELL SALELARTEK SDKALEKLIL DNPVLGDCLV 
      1860       1870       1880       1890       1900
FHGGPEEYFD QTLFQTSTGL INKYTVGIAC LTVGLGCTIW YYLKKREKYV 
      1910       1920       1930       1940       1950
MHGKVHTRET GLTTNHLFVP GMKEHIQEWT GGDHEIGNRF GEAYKRRFIG 
      1960       1970       1980       1990       2000
RQPTEEQKLS KEKWDKREGQ QTSVYKTLYD LDPTKFKYVV VECPDFDLKK 
      2010       2020       2030       2040       2050
KLNRQEKKQL DTTIVEACRT RMLDKGQHDF KDVERATVYL FNDNGVGHKV 
      2060       2070       2080       2090       2100
QLTPHNPLAV SRTTTHPVGF PAEAGRLRQT GQAMEMTPEE LEKALDDNYV 
      2110       2120       2130       2140       2150
PHSRCQIDIS HLHRHLAIVN TGGMSTQCFI TQTMCVAPYH LAMGFKDNTK 
      2160       2170       2180       2190       2200
LTIYCSNGVY VMPVPKVEKM ENMDLVVFRM PQDFPPLKRC ATIREPKSSD 
      2210       2220       2230       2240       2250
EVTLITGKRT THGIQLQFSK VVSIDRKSDT VWKYMIDSVP GVCGGMVMCV 
      2260       2270       2280       2290       2300
EDGCVVGFHS AAAIRNKVSN GSIFTPVTPQ LLDSLQSSEG HLFDWYFNDD 
      2310       2320       2330       2340       2350
LISWKGVPTN MDPRNFPVSE TISEFIFHND SKGHGTDKYY GENLTIEGRV 
      2360       2370       2380       2390       2400
LQSFNTRHVV KGLDDAFAEY VNKFGEPPAD TFTHLPSDLS SDAFYKDFMK 
      2410       2420       2430       2440       2450
YSTPVEVGTV NIENFEKAVQ AVVELLEQQG FEQGEFSPEM DFYKILNSFN 
      2460       2470       2480       2490       2500
LDTAMGALYQ CKKKDVLPMA SHEQLATWFW NSLENLATGK LGLWKASLKA 
      2510       2520       2530       2540       2550
ELRPKEKVLE KKTRVFTAAP FDVSFGAKAF VDDFNNKFYA TQAGSNWTVG 
      2560       2570       2580       2590       2600
INKFNCGWDE LARRFNPDWK FIDADGSRYD SSLTPLLFNA VLRIRQHFLR 
      2610       2620       2630       2640       2650
ANGFERRMLS NFYTQLVWTP ISTITGQIVK KNKGGPSGQP STVVDNTMML 
      2660       2670       2680       2690       2700
MIAVEYAKLQ YGVTDLKYVC NGDDLILNAP QGVCETIRAN FSHSFKELGL 
      2710       2720       2730       2740       2750
TYEFEQEVDS IDQVEYMSHK WIDCGGVLIP KLKPERIVSV LQWNKSLDLA 
      2760       2770       2780       2790       2800
SQANKINAAW IESFGYGDLS KFIREYANWW GERNGQVGFL CSEEKVASLY 
      2810       2820       2830       2840       2850
LTNDVTIHTE EHDEFVFHSG ADQSGVVKDQ TGDKAEGSGT KTEDPPNQTT 
      2860       2870       2880       2890       2900
DPVNNPSNGG NKDAPQNLNA TVVTKSYTYI PPIMKSLVTI DTAKKMADYT 
      2910       2920       2930       2940       2950
PPDALISTQA CTLEQFGRWA NAAANGLGLS MQAFQTDVVP YWIYWCIVNS 
      2960       2970       2980       2990       3000
ASDEHKKLSS WTKVNMTIDD ATGQINLNEG EAQTIYEMSP MFDEAKPTLR 
      3010       3020       3030       3040       3050
AVMRHFGALA YRWVKFSIAK RKPIIPHNAI KAGLMDVTYF PCCIDFVTVD 
      3060       3070       3080       3090       3100
QLSPQEQNVR NQVINARVSD TPRALFKHAQ RAGAGEEDTN LRRDDDANYG 
      3110 
RTRVGGAMFG TR
Length:3,112
Mass (Da):352,841
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B066BBD6C5D5151
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2819S → E AA sequence (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FJ263671 Genomic RNA Translation: ABO41208.2

NCBI Reference Sequences

More...RefSeqi		YP_002956073.1, NC_012799.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7984336

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:7984336

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ263671 Genomic RNA Translation: ABO41208.2
RefSeqiYP_002956073.1, NC_012799.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiA4KZ49

Genome annotation databases

GeneIDi7984336
KEGGivg:7984336

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR025910, P1_Ser_Pept_dom
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF13611, Peptidase_S76, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_TRMVU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4KZ49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 13, 2010
Last modified: December 2, 2020
This is version 72 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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