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Entry version 81 (12 Aug 2020)
Sequence version 2 (05 May 2009)
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Protein

Ent-isokaur-15-ene synthase

Gene

KSL6

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of ent-copalyl diphosphate to the phytoalexin precursor ent-isokaur-15-ene.

Miscellaneous

Phytoalexins are diterpenoid secondary metabolites involved in the defense mechanism of the plant and produced in response to attack (by a pathogen, elicitor or UV irradiation).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi556Magnesium 1By similarity1
Metal bindingi556Magnesium 2By similarity1
Metal bindingi560Magnesium 1By similarity1
Metal bindingi560Magnesium 2By similarity1
Metal bindingi701Magnesium 3By similarity1
Metal bindingi705Magnesium 3By similarity1
Metal bindingi709Magnesium 3By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processPlant defense
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-18623

Reactome - a knowledgebase of biological pathways and processes for plant species

More...
PlantReactomei
R-OSA-9610720, Oryzalide A biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ent-isokaur-15-ene synthase (EC:4.2.3.103)
Alternative name(s):
Ent-kaurene synthase-like 5
Short name:
OsKS5
Ent-kaurene synthase-like 6
Short name:
OsKS6
Short name:
OsKSL6
Iso-kaurene synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KSL6
Synonyms:KS5
Ordered Locus Names:Os02g0571800, LOC_Os02g36264
ORF Names:P0689H05.34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000059680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2
  • UP000000763 Componenti: Chromosome 2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi664I → T: Changes catalytic activity. Converts ent-copalyl diphosphate to ent-pimara-8(14),15-diene and diphosphate. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003723191 – 821Ent-isokaur-15-ene synthaseAdd BLAST821

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A4KAG8

PRoteomics IDEntifications database

More...
PRIDEi
A4KAG8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots and stems.1 Publication

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A4KAG8, OS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS02T0571800-00

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A4KAG8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi556 – 560DDXXD motif5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the terpene synthase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVGX, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003125_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4KAG8

KEGG Orthology (KO)

More...
KOi
K16082

Identification of Orthologs from Complete Genome Data

More...
OMAi
MRTCAMA

Database of Orthologous Groups

More...
OrthoDBi
1658056at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.600.10, 1 hit
1.50.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008949, Isoprenoid_synthase_dom_sf
IPR001906, Terpene_synth_N
IPR036965, Terpene_synth_N_sf
IPR005630, Terpene_synthase_metal-bd
IPR008930, Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01397, Terpene_synth, 1 hit
PF03936, Terpene_synth_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239, SSF48239, 2 hits
SSF48576, SSF48576, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4KAG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLPMSSACS GGQFPGASPH GIIPKQFSRA PRIRVSIRGA AGVEKSLGLG
60 70 80 90 100
RNAGSQQGMH KNELHDKIRK QLRDVQLQPS SYDTAWVAMV PVQGSHQTPR
110 120 130 140 150
FPQSIEWILQ NQYDDGSWGT NLPGLVVNKD ILLCTLACVV ALKRWNTGRD
160 170 180 190 200
HISRGLNFIG RNFSVAMDEQ TVAPVGFNIT FSGLLSLATR TGLELPVMQT
210 220 230 240 250
DIDGIIHIRK IELERDAYGT ASSRRAFMAY VSEGLGNLQD WNQVMAYQRK
260 270 280 290 300
NGSIFNSPSA TAATIIHGHN YSGLAYLDFV TSKFGGPVPV MYPQNAYSQL
310 320 330 340 350
CMVDTLERMG ISESFACEIS DILDMTYRLW MHNEEELMLD MRTCAMAFRL
360 370 380 390 400
LRMHGYDITS DGMAQFVEQS SFDDSIHGYL NDTKALLELY KSSQLRCLED
410 420 430 440 450
DLILEEIGSW SARVLLEKIS SKMIHISELP EVEYALKCPV YAILERLEQK
460 470 480 490 500
RNIEQFKTKE QLKIEGFKLL KSGYRGVIPN DEILALAVDE FHSSQSVYQQ
510 520 530 540 550
ELQDLNSWVA HTRLDELKFA RLMPSITYFS AAAVLLPSES ARIAWTQNCI
560 570 580 590 600
LTTTVDDFFD GEGSKEEMEN LVKLIEKWDD HGEIGFSSEC VEILFYAVYN
610 620 630 640 650
TSKQIAEKAM PLQKRNAVDH IAESWWFTVR GMLTEAEWRM DKYVPTTVEE
660 670 680 690 700
YMSAAVDSFA VGPIITSAAL FVGPELSEEV FRSEEYIHLM NLANTIGRLL
710 720 730 740 750
NDMQTYEKEI KMGKVNSVML HALSHSGGGR GSPEASMEEA KREMRRVLQG
760 770 780 790 800
CRFELLRLVT RDAGVVPPPC RKLFWLMSKV LHFVYMEKDR YFTAEGMMAS
810 820
ANAVILDPLQ VTLPPSDSGT L
Length:821
Mass (Da):92,408
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2191522B9B719A5D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD17276 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF09105 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92V → A in BAE72101 (PubMed:16861806).Curated1
Sequence conflicti156L → P in ABH10733 (PubMed:17141283).Curated1
Sequence conflicti156L → P in AAQ72564 (PubMed:15668792).Curated1
Sequence conflicti757R → G in ABH10733 (PubMed:17141283).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ823353 mRNA Translation: ABH10733.1
AP005114 Genomic DNA Translation: BAD17276.1 Sequence problems.
AP008208 Genomic DNA Translation: BAF09105.1 Sequence problems.
AP014958 Genomic DNA Translation: BAS79348.1
AY347881 mRNA Translation: AAQ72564.1
AB126936 mRNA Translation: BAE72101.1

NCBI Reference Sequences

More...
RefSeqi
XP_015625945.1, XM_015770459.1
XP_015625947.1, XM_015770461.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
Os02t0571800-00; Os02t0571800-00; Os02g0571800

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4329729

Gramene; a comparative resource for plants

More...
Gramenei
Os02t0571800-00; Os02t0571800-00; Os02g0571800

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4329729

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ823353 mRNA Translation: ABH10733.1
AP005114 Genomic DNA Translation: BAD17276.1 Sequence problems.
AP008208 Genomic DNA Translation: BAF09105.1 Sequence problems.
AP014958 Genomic DNA Translation: BAS79348.1
AY347881 mRNA Translation: AAQ72564.1
AB126936 mRNA Translation: BAE72101.1
RefSeqiXP_015625945.1, XM_015770459.1
XP_015625947.1, XM_015770461.1

3D structure databases

SMRiA4KAG8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS02T0571800-00

Proteomic databases

PaxDbiA4KAG8
PRIDEiA4KAG8

Genome annotation databases

EnsemblPlantsiOs02t0571800-00; Os02t0571800-00; Os02g0571800
GeneIDi4329729
GrameneiOs02t0571800-00; Os02t0571800-00; Os02g0571800
KEGGiosa:4329729

Phylogenomic databases

eggNOGiENOG502QVGX, Eukaryota
HOGENOMiCLU_003125_2_0_1
InParanoidiA4KAG8
KOiK16082
OMAiMRTCAMA
OrthoDBi1658056at2759

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18623
PlantReactomeiR-OSA-9610720, Oryzalide A biosynthesis

Gene expression databases

GenevisibleiA4KAG8, OS

Family and domain databases

Gene3Di1.10.600.10, 1 hit
1.50.10.130, 1 hit
InterProiView protein in InterPro
IPR008949, Isoprenoid_synthase_dom_sf
IPR001906, Terpene_synth_N
IPR036965, Terpene_synth_N_sf
IPR005630, Terpene_synthase_metal-bd
IPR008930, Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF01397, Terpene_synth, 1 hit
PF03936, Terpene_synth_C, 1 hit
SUPFAMiSSF48239, SSF48239, 2 hits
SSF48576, SSF48576, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKSL6_ORYSJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4KAG8
Secondary accession number(s): A0A0P0VKP2
, Q0E083, Q2PHF1, Q69DS6, Q6Z5J0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: August 12, 2020
This is version 81 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families
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