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Protein

Potassium voltage-gated channel subfamily S member 1

Gene

KCNS1

Organism
Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 1
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 1
Voltage-gated potassium channel subunit Kv9.1
Gene namesi
Name:KCNS1
OrganismiColobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey)
Taxonomic identifieri33548 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeColobus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 217CytoplasmicBy similarityAdd BLAST217
Transmembranei218 – 239Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini240 – 270ExtracellularBy similarityAdd BLAST31
Transmembranei271 – 293Helical; Name=Segment S2By similarityAdd BLAST23
Topological domaini294 – 304CytoplasmicBy similarityAdd BLAST11
Transmembranei305 – 322Helical; Name=Segment S3By similarityAdd BLAST18
Topological domaini323 – 340ExtracellularBy similarityAdd BLAST18
Transmembranei341 – 361Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini362 – 376CytoplasmicBy similarityAdd BLAST15
Transmembranei377 – 398Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini399 – 411ExtracellularBy similarityAdd BLAST13
Intramembranei412 – 423Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei424 – 431By similarity8
Topological domaini432 – 438ExtracellularBy similarity7
Transmembranei439 – 467Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini468 – 529CytoplasmicBy similarityAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002896151 – 529Potassium voltage-gated channel subfamily S member 1Add BLAST529

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Does not form homomultimers.By similarity

Structurei

3D structure databases

ProteinModelPortaliA4K2P6
SMRiA4K2P6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi424 – 429Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi250 – 259Poly-Ala10

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052230

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

A4K2P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMLLVRGTR YESLRSKVVL PTPLGGRGTE VLVSESPSPD TGIRWRQSDE
60 70 80 90 100
ALRVNVGGVR RLLSARALAR FPGTRLGRLQ AAASEEQARR LCDDYDAAAR
110 120 130 140 150
EFYFDRHPGF FLGLLHFYRT GHLHVLDELC VFAFGQEADY WGLGENVLAA
160 170 180 190 200
CCRARYLERR LTQPRAWDED SDTPSSVDPC PDEISDVQRE LARYGAARCG
210 220 230 240 250
RLRRRLWLTM ENPGYSLPSK LFSCVSISVV LASIAAMCIH SLPEYQAREA
260 270 280 290 300
AAAVAAVAAG RSPEGVRDDP VLRRLEYFCI AWFSFEVSSR LLLAPSTRNF
310 320 330 340 350
FCHPLNLIDI VSVLPFYLTL LAGVALGDQG GTGGKELGHL GKVVQVFRLM
360 370 380 390 400
RIFRVLKLAR HSTGLRSLGA TLKHSYREVG ILLLYLAVGV SVFSGVAYTA
410 420 430 440 450
EKEEDVGFNT IPACWWWGTV SMTTVGYGDV VPVTVAGKLA ASGCILGGIL
460 470 480 490 500
VVALPITIIF NKFSHFYRRQ KALEAAVRNS NHQEFEDLLS SVDEVSEASL
510 520
ETSREISQEG RSADLETQAP SEPPHPQMY
Length:529
Mass (Da):58,477
Last modified:May 1, 2007 - v1
Checksum:i949519DEA533964D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000038 Genomic DNA Translation: ABO52931.1

Similar proteinsi

Entry informationi

Entry nameiKCNS1_COLGU
AccessioniPrimary (citable) accession number: A4K2P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2007
Last modified: February 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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