Si:ch211-190h2.4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: ZFIN <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Large-scale screening for novel low-affinity extracellular protein interactions."
    Bushell K.M., Soellner C., Schuster-Boeckler B., Bateman A., Wright G.J.
    Genome Res. 18:622-630(2008) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• axonogenesis involved in innervation Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfinding."
    Diekmann H., Stuermer C.A.
    J Comp Neurol 513:38-50(2009) [PubMed] [Europe PMC] [Abstract]
• forebrain cell migration Source: ZFINInferred from mutant phenotypeⁱ
  • "Nlcam modulates midline convergence during anterior neural plate morphogenesis."
    Brown K.E., Keller P.J., Ramialison M., Rembold M., Stelzer E.H., Loosli F., Wittbrodt J.
    Dev Biol 339:14-25(2010) [PubMed] [Europe PMC] [Abstract]
• retinal ganglion cell axon guidance Source: ZFINInferred from mutant phenotypeⁱ
  • "Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfinding."
    Diekmann H., Stuermer C.A.
    J Comp Neurol 513:38-50(2009) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: ZFINInferred from direct assayⁱ
  • "Large-scale screening for novel low-affinity extracellular protein interactions."
    Bushell K.M., Soellner C., Schuster-Boeckler B., Bateman A., Wright G.J.
    Genome Res. 18:622-630(2008) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Keywords - Domainⁱ

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MQRTAFLTCL LTVSLMNQVW GLETVTGKYG DTVEIPCNSG LVSDVGVTFV 
        60         70         80         90        100
KWKSDKDGSI LVKHTGQNAS SPTDGNYKNR VSIKKDFGLI ITQVSLADQK 
       110        120        130        140        150
TFTCMVVAAD DILEYPVQLV IYKTPLQPQI ANLTTAMEIG KLTTLAQCHT 
       160        170        180        190        200
EGANPAANIT WFKNKTPLIA DGTAIKITND VAVDKATGLS ATTSKLEYTA 
       210        220        230        240        250
VKDDINSKFT CQVQHIKSAN MDSSPLVFTV NYPSETISFH VLPDGPVKEG 
       260        270        280        290        300
DNVTLKCTAD GNPPPSRYNF YIKGEKKTVE KSNIFILSNV TRQNTGEYKC 
       310        320        330        340        350
SLVDNEILTA SKNITVEYLD VILSTTGKVF KKLGDSFETT LDIKASGKTE 
       360        370        380        390        400
TFCKKGGEKL VGPPKFASLK YTDSGVYECV VTMLGLKKTQ TFDLNVHGQP 
       410        420        430        440        450
LIKSLTKKRG DGTNKILSCE AEGSPKPTVQ WITNGTDVKF QESEHVNGKI 
       460        470        480        490        500
TYYITVSPKA NVTVSCTISN DLGSDTRSID VSSLVEDVTM DKQDQSEDYS 
       510        520        530        540        550
DQTALAVGIV VGLMLAALLI GLAYWLYMKK FRQGSWKTGE KEDESAEESK 
       560 
KLEENQSQKA EV                                          

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Organism-specific databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ